KEGG   PATHWAY: mna04530
Entry
mna04530                    Pathway                                
Name
Tight junction - Miniopterus natalensis (Natal long-fingered bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mna04530  Tight junction
mna04530

Other DBs
GO: 0005923
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107525750  CRB3; protein crumbs homolog 3 [KO:K06090]
107533012  CLDN34; claudin-34 [KO:K06087]
107532131  CLDN2; claudin-2 [KO:K06087]
107541283  claudin-22-like [KO:K06087]
107541286  putative claudin-24 [KO:K06087]
107541287  claudin-22-like [KO:K06087]
107526510  CLDN15; claudin-15 [KO:K06087]
107531162  CLDN19; claudin-19 [KO:K06087]
107535846  CLDN6; claudin-6 [KO:K06087]
107535847  CLDN9; claudin-9 [KO:K06087]
107526582  CLDN3; claudin-3 [KO:K06087]
107526583  CLDN4; claudin-4 isoform X1 [KO:K06087]
107527366  CLDN16; claudin-16 [KO:K06087]
107527824  CLDN20; claudin-20 [KO:K06087]
107531292  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
107544613  CLDN7; claudin-7 [KO:K06087]
107527299  CLDN1; claudin-1 [KO:K06087]
107546080  CLDN18; claudin-18 isoform X1 [KO:K06087]
107543691  CLDN14; claudin-14 [KO:K06087]
107529521  CLDN11; claudin-11 [KO:K06087]
107545903  CLDN10; claudin-10 isoform X1 [KO:K06087]
107539888  CLDN17; claudin-17 [KO:K06087]
107530497  CLDN5; claudin-5 [KO:K06087]
107541738  CLDN12; claudin-12 [KO:K06087]
107537805  OCLN; occludin [KO:K06088]
107535112  F11R; junctional adhesion molecule A [KO:K06089]
107525477  JAM2; junctional adhesion molecule B [KO:K06735]
107540599  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
107540726  BVES; blood vessel epicardial substance [KO:K21108]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107540891  cell division control protein 42 homolog [KO:K04393]
107541559  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
107538237  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
107542884  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
107545672  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
107533926  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
107525633  TJP3; tight junction protein ZO-3 [KO:K06097]
107531752  PATJ; inaD-like protein [KO:K06092]
107538093  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
107540144  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107529541  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107525794  AMOT; angiomotin [KO:K16819]
107532431  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
107546117  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
107544776  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107526198  NF2; merlin isoform X1 [KO:K16684]
107536644  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
107524532  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
107527282  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
107544221  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
107525394  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107534103  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107540441  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107531299  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
107524098  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
107529884  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
107530370  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
107529477  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
107525082  PARD3; partitioning defective 3 homolog [KO:K04237]
107533494  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
107527961  TJP1; tight junction protein ZO-1 [KO:K05701]
107536918  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
107532464  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
107532901  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
107546531  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
107545427  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
107540783  CGN; cingulin [KO:K06102]
107533746  CGNL1; cingulin-like protein 1 [KO:K21110]
107543816  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
107529450  RHOA; transforming protein RhoA [KO:K04513]
107527482  GATA4; transcription factor GATA-4 [KO:K09183]
107525289  MARVEL domain-containing protein 3-like [KO:K21099]
107524307  MARVEL domain-containing protein 3-like [KO:K21099]
107527145  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107541574  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
107541575  antigen-presenting glycoprotein CD1d-like [KO:K06448]
107541579  T-cell surface glycoprotein CD1b-2-like isoform X1 [KO:K06448]
107524880  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
107546223  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107543062  Y-box-binding protein 3-like [KO:K06099]
107544713  Y-box-binding protein 3-like [KO:K06099]
107536751  SYMPK; symplekin isoform X1 [KO:K06100]
107536383  PCNA; proliferating cell nuclear antigen [KO:K04802]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107529006  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107533502  RUNX1; runt-related transcription factor 1 [KO:K08367]
107525401  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
107542931  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
107541875  EZR; ezrin [KO:K08007]
107529991  RDX; radixin [KO:K05762]
107534899  MSN; moesin [KO:K05763]
107530341  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
107539076  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107537600  ACTB; actin, cytoplasmic 1 [KO:K05692]
107534931  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
107530984  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
107529906  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107542143  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107540361  CTTN; src substrate cortactin [KO:K06106]
107527398  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
107545978  ACTR2; actin-related protein 2 [KO:K17260]
107524922  ACTR3B; actin-related protein 3B [KO:K18584]
107526917  ACTR3; actin-related protein 3 [KO:K18584]
107540948  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
107540907  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107524752  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
107529597  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107534754  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107535481  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107546303  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107539234  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
107541349  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
107536769  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107543760  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
107540642  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
107535907  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107542396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
107529566  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107537630  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
107534576  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107545893  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107530645  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107543870  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
107528511  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
107528241  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
107524897  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
107524851  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
107524357  MYH11; myosin-11 [KO:K10352]
107531785  MYH14; myosin-14 [KO:K10352]
107544543  MYH10; myosin-10 [KO:K10352]
107544784  MYH9; myosin-9 [KO:K10352]
107533389  myosin light polypeptide 6-like [KO:K12751]
107546178  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
107546180  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
107544330  myosin regulatory light polypeptide 9 [KO:K12755]
107542167  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107535889  myosin regulatory light chain 12B [KO:K12757]
107535890  myosin regulatory light polypeptide 9 [KO:K12757]
107543569  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
107545056  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
107535224  SYNPO; synaptopodin [KO:K21112]
107532204  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
107545701  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
107537058  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
107534318  RAB8A; ras-related protein Rab-8A [KO:K07901]
107533721  RAB8B; ras-related protein Rab-8B [KO:K07902]
107525016  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
107545324  RAP1A; ras-related protein Rap-1A [KO:K04353]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107537017  MLLT4; afadin isoform X1 [KO:K05702]
107538123  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
107527478  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
107525762  RAP2C; ras-related protein Rap-2c [KO:K07839]
107537804  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
107530489  tubulin alpha-3 chain [KO:K07374]
107542424  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
107528244  tubulin alpha-1B chain-like [KO:K07374]
107528245  tubulin alpha-1B chain isoform X1 [KO:K07374]
107528246  tubulin alpha-1B chain isoform X1 [KO:K07374]
107524780  TUBA4A; tubulin alpha-4A chain [KO:K07374]
107524054  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107524827  tubulin alpha-1D chain-like [KO:K07374]
107541660  tubulin alpha-1C chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mna04520  Adherens junction
mna04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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