KEGG   PATHWAY: nfu04310
Entry
nfu04310                    Pathway                                
Name
Wnt signaling pathway - Nothobranchius furzeri (turquoise killifish)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
nfu04310  Wnt signaling pathway
nfu04310

Other DBs
GO: 0016055
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107390509  porcn; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
107390546  protein-serine O-palmitoleoyltransferase porcupine-like [KO:K00181] [EC:2.3.1.250]
107390891  wnt1; proto-oncogene Wnt-1 [KO:K03209]
107390935  protein Wnt-2b-A [KO:K00182]
107385361  wnt2b; protein Wnt-2b [KO:K00182]
107395256  protein Wnt-2-like [KO:K00182]
107387617  proto-oncogene Wnt-3 [KO:K00312]
107383855  wnt3a; protein Wnt-3a [KO:K00312]
107379462  protein Wnt-4-like [KO:K00408]
107374130  wnt4; protein Wnt-4 [KO:K00408]
107385014  protein Wnt-5b [KO:K00444]
107391003  wnt5a; protein Wnt-5a [KO:K00444]
107390192  wnt6; protein Wnt-6 [KO:K00445]
107391103  wnt7a; protein Wnt-7a [KO:K00572]
107395904  protein Wnt-7a-like [KO:K00572]
107388424  protein Wnt-7b isoform X1 [KO:K00572]
107384032  wnt7b; protein Wnt-7b [KO:K00572]
107373747  protein Wnt-8a-like [KO:K00714]
107373748  protein Wnt-8a-like [KO:K00714]
107375911  protein Wnt-8b [KO:K00714]
107378473  protein Wnt-9b-like [KO:K01064]
107383854  wnt9a; protein Wnt-9a [KO:K01064]
107390892  wnt10b; protein Wnt-10b [KO:K01357]
107390191  wnt10a; protein Wnt-10a [KO:K01357]
107386013  wnt11; protein Wnt-11 [KO:K01384]
107372976  wnt16; protein Wnt-16 [KO:K01558]
107382449  DAN domain family member 5-like [KO:K01645]
107392326  notum; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
107392851  carboxylesterase notum2-like [KO:K19882] [EC:3.1.1.98]
107387626  sost; sclerostin [KO:K16834]
107376028  dkk1; dickkopf-related protein 1 [KO:K02165]
107375267  dkk2; dickkopf-related protein 2 isoform X1 [KO:K02165]
107387166  serpinf1; pigment epithelium-derived factor [KO:K19614]
107388632  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
107380463  secreted frizzled-related protein 2-like [KO:K02176]
107389533  secreted frizzled-related protein 3-like [KO:K25481]
107375685  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
107379347  rspo1; R-spondin-1 [KO:K19471]
107384986  R-spondin-2-like isoform X1 [KO:K23097]
107378916  rspo2; R-spondin-2 [KO:K23097]
107378022  R-spondin-3-like [KO:K23098]
107378789  R-spondin-3-like [KO:K23098]
107381471  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
107387630  leucine-rich repeat-containing G-protein coupled receptor 5A-like [KO:K04308]
107390955  lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
107387041  rnf43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
107386232  znrf3; E3 ubiquitin-protein ligase ZNRF3 isoform X1 [KO:K16273] [EC:2.3.2.27]
107373836  frizzled-1-like [KO:K02432]
107390230  frizzled-7-A-like [KO:K02432]
107383092  frizzled-7-like [KO:K02432]
107378452  fzd2; frizzled-2 [KO:K02235]
107395717  frizzled-3-like isoform X1 [KO:K02329]
107381211  frizzled-3-like isoform X1 [KO:K02329]
107380449  fzd4; frizzled-4 [KO:K02354]
107383432  frizzled-8-like [KO:K02375]
107382655  fzd8; frizzled-8 [KO:K02375]
107389686  frizzled-5-like [KO:K02375]
107378841  fzd6; frizzled-6 isoform X1 [KO:K02376]
107380486  fzd9; frizzled-9 [KO:K02842]
107393626  fzd10; frizzled-10 [KO:K02842]
107389509  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
107387741  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
107382771  bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
107385403  protein APCDD1-like [KO:K25812]
107383547  protein APCDD1-like [KO:K25812]
107376305  csnk1e; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
107388239  casein kinase I isoform epsilon-like isoform X1 [KO:K08960] [EC:2.7.11.1]
107391703  ccdc88c; protein Daple [KO:K25811]
107390467  dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
107379914  dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
107372429  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
107384150  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
107379012  GSK-3-binding protein-like [KO:K03096]
107378666  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
107382049  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107389232  casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
107394518  casein kinase II subunit beta [KO:K03115]
107378672  casein kinase II subunit beta-like [KO:K03115]
107381239  nkd1; protein naked cuticle homolog 1 [KO:K03213]
107396735  CXXC-type zinc finger protein 5-like [KO:K03344]
107375279  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
107392107  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
107389867  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107394374  catenin beta-1-like [KO:K02105]
107378799  ctnnb1; catenin beta-1 [KO:K02105]
107378411  axin1; axin-1 [KO:K02157]
107395828  axin-1-like [KO:K02157]
107390091  axin2; axin-2 [KO:K04385]
107376523  axin-2-like [KO:K04385]
107374978  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107392633  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
107387879  csnk1a1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
107386837  tcf7; transcription factor 7 isoform X1 [KO:K02620]
107378492  pollen-specific leucine-rich repeat extensin-like protein 1 [KO:K02620]
107393717  tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
107395259  transcription factor 7-like 1-B isoform X1 [KO:K04490]
107387573  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
107375038  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
107375714  lzts2; leucine zipper putative tumor suppressor 2 [KO:K26471]
107390758  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
107395151  cby1; protein chibby homolog 1 [KO:K23402]
107384251  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
107375374  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
107382529  transcription factor Sox-17-alpha-like [KO:K04495]
107387783  C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
107375984  C-terminal-binding protein 2-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107379536  ctbp1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
107375331  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
107388705  protein groucho-2 isoform X1 [KO:K04497]
107394045  tle1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]
107394311  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
107393190  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
107381745  tle3; transducin-like enhancer protein 3 isoform X1 [KO:K04497]
107383010  catenin delta-2-like [KO:K23491]
107384204  catenin delta-2-like isoform X1 [KO:K23491]
107376486  crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
107376331  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
107390552  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107388223  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107385709  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
107379013  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107394046  mothers against decapentaplegic homolog 4-like [KO:K04501]
107373891  mothers against decapentaplegic homolog 4-like [KO:K04501]
107388715  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107395980  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107372837  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
107394986  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
107383716  transcriptional regulator Myc-1-like [KO:K04377]
107385060  transcriptional regulator Myc-2-like [KO:K04377]
107382539  myc; myc proto-oncogene protein [KO:K04377]
107396464  transcription factor AP-1-like [KO:K04448]
107384375  jun; transcription factor AP-1 [KO:K04448]
107374449  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
107378596  G1/S-specific cyclin-D2-like [KO:K10151]
107386279  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
107389327  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
107385769  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
107394377  wisp1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
107390828  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
107391854  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
107392711  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107383895  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
107378291  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
107395214  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107377392  tp53; cellular tumor antigen p53 [KO:K04451]
107389144  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
107383987  cacybp; calcyclin-binding protein [KO:K04507]
107386838  skp1; S-phase kinase-associated protein 1 [KO:K03094]
107387346  tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
107389931  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
107376245  fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
107383137  cul1; cullin-1 [KO:K03347]
107376330  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107379649  glypican-4-like [KO:K08110]
107392918  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
107395100  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
107396636  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
107381036  vangl1; vang-like protein 1 isoform X1 [KO:K04510]
107389917  vang-like protein 1 [KO:K04510]
107383479  vangl2; vang-like protein 2 [KO:K04510]
107377170  vang-like protein 2 isoform X1 [KO:K04510]
107391140  prickle-like protein 2 isoform X1 [KO:K04511]
107384542  prickle1; prickle-like protein 1 isoform X1 [KO:K04511]
107390493  prickle3; prickle-like protein 3 [KO:K04511]
107372407  prickle-like protein 1 [KO:K04511]
107385444  prickle2; prickle-like protein 2 [KO:K04511]
107379726  invs; inversin isoform X1 [KO:K19626]
107396948  disheveled-associated activator of morphogenesis 1-like [KO:K04512]
107377580  daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
107391723  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
107390661  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107391369  rho-related GTP-binding protein RhoA-C [KO:K04513]
107385104  rho-related GTP-binding protein RhoA-B [KO:K04513]
107390932  rho-related GTP-binding protein RhoC [KO:K04513]
107396125  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
107377468  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
107376513  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107388167  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107388169  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107388170  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107388172  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107388173  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107391413  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107395638  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107374715  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107375912  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107375638  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107388204  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107378111  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107376107  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107377124  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107392485  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107378065  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
107395908  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
107384728  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107382167  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
107375859  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107387740  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107386224  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
107387181  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
107390263  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107376893  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
107386394  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107380138  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107393481  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107376079  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
107391584  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107376518  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
107388621  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
107376405  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107379571  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
107378925  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107394905  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
107390454  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107385406  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
107388393  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
107381886  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107383484  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
nfu04010  MAPK signaling pathway
nfu04110  Cell cycle
nfu04115  p53 signaling pathway
nfu04120  Ubiquitin mediated proteolysis
nfu04350  TGF-beta signaling pathway
nfu04510  Focal adhesion
nfu04520  Adherens junction
KO pathway
ko04310   
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