KEGG   PATHWAY: nfu04010
Entry
nfu04010                    Pathway                                
Name
MAPK signaling pathway - Nothobranchius furzeri (turquoise killifish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nfu04010  MAPK signaling pathway
nfu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107372320  [KO:K04402]
107372367  [KO:K04376]
107372384  [KO:K04388] [EC:2.7.11.30]
107372661  [KO:K22603]
107372696  [KO:K04358]
107372823  [KO:K03283]
107372837  [KO:K04468] [EC:2.7.11.24]
107372838  [KO:K04856]
107373003  [KO:K12362]
107373420  [KO:K25415]
107373566  [KO:K04429] [EC:2.7.11.1]
107373573  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107373577  [KO:K04455]
107373664  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
107373767  gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
107373800  fgf3; fibroblast growth factor 3 [KO:K04358]
107373814  [KO:K05866] [EC:3.1.3.48]
107373887  [KO:K04358]
107373888  [KO:K04359]
107373895  [KO:K03283]
107374062  [KO:K04453]
107374323  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107374334  [KO:K04674] [EC:2.7.11.30]
107374414  [KO:K12362]
107374467  [KO:K04381]
107374468  [KO:K12326]
107374607  [KO:K04871]
107374715  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107374736  [KO:K04360] [EC:2.7.10.1]
107374766  egf; pro-epidermal growth factor [KO:K04357]
107374859  [KO:K03173] [EC:2.3.2.27]
107374959  [KO:K05462]
107374982  fgf16; fibroblast growth factor 16 [KO:K04358]
107375027  [KO:K04402]
107375063  [KO:K04402]
107375089  [KO:K18496]
107375116  [KO:K04849]
107375153  [KO:K04867]
107375154  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107375164  [KO:K04374]
107375167  pdgfb; platelet-derived growth factor subunit B [KO:K17386]
107375369  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107375397  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107375408  srf; serum response factor isoform X1 [KO:K04378]
107375498  [KO:K04358]
107375593  [KO:K04467] [EC:2.7.11.10]
107375638  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107375657  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107375663  [KO:K05090] [EC:2.7.10.1]
107375798  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
107375814  [KO:K17534] [EC:2.7.11.25]
107375824  [KO:K04456] [EC:2.7.11.1]
107375843  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
107375912  [KO:K04440] [EC:2.7.11.24]
107376035  [KO:K04390]
107376079  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
107376164  [KO:K04856]
107376202  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107376249  grb2; growth factor receptor-bound protein 2 [KO:K04364]
107376280  [KO:K04358]
107376364  [KO:K04374]
107376404  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
107376405  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107376493  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
107376513  [KO:K04392]
107376517  [KO:K04870]
107376518  [KO:K02677] [EC:2.7.11.13]
107376576  [KO:K04869]
107376577  [KO:K04866]
107376608  [KO:K04347]
107376625  [KO:K04344]
107376655  [KO:K07827]
107376671  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
107376681  [KO:K04371] [EC:2.7.11.24]
107376712  [KO:K04855]
107376723  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
107376748  [KO:K04419] [EC:2.7.11.25]
107376749  [KO:K04735]
107376893  [KO:K04348] [EC:3.1.3.16]
107376975  pea15; astrocytic phosphoprotein PEA-15 [KO:K29115]
107377226  [KO:K05085] [EC:2.7.10.1]
107377308  [KO:K04358]
107377392  tp53; cellular tumor antigen p53 [KO:K04451]
107377426  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
107377518  [KO:K13377]
107377523  [KO:K04379]
107377524  [KO:K04379]
107377547  [KO:K13376]
107377612  vegfb; vascular endothelial growth factor B [KO:K05448]
107377696  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107377786  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
107377824  [KO:K04453]
107378043  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
107378093  [KO:K05448]
107378273  [KO:K04433] [EC:2.7.12.2]
107378291  [KO:K04345] [EC:2.7.11.11]
107378477  [KO:K04466] [EC:2.7.11.25]
107378519  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
107378530  [KO:K05096] [EC:2.7.10.1]
107378534  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
107378565  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
107378633  [KO:K04381]
107378854  [KO:K04389]
107378925  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107379148  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107379353  [KO:K04426] [EC:2.7.11.25]
107379450  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
107379463  [KO:K04393]
107379571  [KO:K19663] [EC:2.7.11.13]
107379572  [KO:K04872]
107379573  [KO:K04873]
107379576  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
107379609  [KO:K05462]
107379610  [KO:K05462]
107379611  [KO:K05462]
107379762  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107379818  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
107379821  [KO:K13375]
107379830  [KO:K04350]
107379856  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
107379882  [KO:K04723]
107379904  arrb1; beta-arrestin-1 [KO:K04439]
107380014  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
107380091  [KO:K03283]
107380117  [KO:K04429] [EC:2.7.11.1]
107380138  [KO:K04348] [EC:3.1.3.16]
107380271  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
107380281  relb; transcription factor RelB isoform X1 [KO:K09253]
107380295  [KO:K04457] [EC:3.1.3.16]
107380334  fgf2; fibroblast growth factor 2 [KO:K18497]
107380445  pdgfd; platelet-derived growth factor D [KO:K05450]
107380489  rasa2; ras GTPase-activating protein 2 [KO:K08053]
107380509  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
107380855  [KO:K05449]
107380887  [KO:K04861]
107380900  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
107380913  [KO:K04865]
107381112  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
107381355  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107381400  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107381433  rras2; ras-related protein R-Ras2 [KO:K07830]
107381483  [KO:K04349]
107381608  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
107381684  figf; vascular endothelial growth factor D isoform X1 [KO:K05449]
107381727  fgf7; fibroblast growth factor 7 [KO:K04358]
107381740  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
107381812  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
107381886  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107382005  [KO:K05087] [EC:2.7.10.1]
107382059  [KO:K04373] [EC:2.7.11.1]
107382191  [KO:K05091] [EC:2.7.10.1]
107382265  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107382268  vegfc; vascular endothelial growth factor C [KO:K05449]
107382497  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
107382539  myc; myc proto-oncogene protein [KO:K04377]
107382677  ntf3; neurotrophin-3 [KO:K04356]
107382819  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107382822  [KO:K04421] [EC:2.7.11.25]
107382872  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
107382874  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107383116  [KO:K04373] [EC:2.7.11.1]
107383161  [KO:K04361] [EC:2.7.10.1]
107383398  [KO:K05466]
107383577  [KO:K25414]
107383587  [KO:K04527] [EC:2.7.10.1]
107383589  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107383716  [KO:K04377]
107383833  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107383886  [KO:K04852]
107383895  [KO:K04345] [EC:2.7.11.11]
107383905  [KO:K04526]
107384115  [KO:K04424] [EC:2.7.11.25]
107384375  jun; transcription factor AP-1 [KO:K04448]
107384647  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
107384720  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
107384762  [KO:K05461]
107384772  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
107384786  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
107384936  [KO:K04444] [EC:2.7.11.1]
107384961  [KO:K04411]
107384963  [KO:K05465]
107385046  [KO:K02582]
107385060  [KO:K04377]
107385115  [KO:K04860]
107385116  [KO:K04851]
107385122  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107385140  [KO:K04859]
107385163  [KO:K08774]
107385197  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
107385213  [KO:K05103] [EC:2.7.10.1]
107385235  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107385298  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107385314  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
107385332  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
107385357  [KO:K04353]
107385560  [KO:K04441] [EC:2.7.11.24]
107385580  [KO:K04407] [EC:2.7.11.1]
107385601  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107385615  [KO:K04465]
107385644  [KO:K04858]
107385652  [KO:K05460]
107385695  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
107385717  [KO:K04444] [EC:2.7.11.1]
107385904  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
107386038  [KO:K04371] [EC:2.7.11.24]
107386057  fgf5; fibroblast growth factor 5 [KO:K04358]
107386182  [KO:K04519]
107386241  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
107386254  [KO:K04358]
107386263  fgf23; fibroblast growth factor 23 [KO:K22428]
107386347  [KO:K03283]
107386394  [KO:K04348] [EC:3.1.3.16]
107386552  [KO:K04457] [EC:3.1.3.16]
107386663  [KO:K16510] [EC:2.7.11.1]
107386693  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107386707  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107386743  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
107386784  [KO:K04526]
107386855  [KO:K04429] [EC:2.7.11.1]
107387034  hspb1; heat shock protein beta-1 [KO:K04455]
107387174  [KO:K04439]
107387189  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107387198  [KO:K04438]
107387288  [KO:K04380]
107387294  [KO:K04466] [EC:2.7.11.25]
107387313  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107387371  [KO:K04402]
107387373  [KO:K04347]
107387425  [KO:K04433] [EC:2.7.12.2]
107387436  [KO:K04358]
107387503  rap1b; ras-related protein Rap-1b [KO:K07836]
107387534  fgf21; fibroblast growth factor 21 [KO:K22429]
107387548  [KO:K04854]
107387627  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107387656  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
107387759  [KO:K04461] [EC:3.1.3.16]
107387814  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107387921  [KO:K02583]
107387934  [KO:K05083] [EC:2.7.10.1]
107387963  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
107387979  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
107388167  [KO:K04392]
107388169  [KO:K04392]
107388170  [KO:K04392]
107388172  [KO:K04392]
107388173  [KO:K04392]
107388204  [KO:K04440] [EC:2.7.11.24]
107388350  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107388393  [KO:K17333]
107388500  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
107388613  [KO:K04868]
107388621  [KO:K19662] [EC:2.7.11.13]
107388720  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107388793  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
107388805  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107388825  [KO:K05087] [EC:2.7.10.1]
107388870  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
107388871  hgf; hepatocyte growth factor [KO:K05460]
107388897  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
107388963  kras; GTPase KRas isoform X1 [KO:K07827]
107389003  hras; GTPase HRas [KO:K02833]
107389021  igf2; insulin-like growth factor II [KO:K13769]
107389031  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107389033  [KO:K18018] [EC:3.1.3.48]
107389066  [KO:K04441] [EC:2.7.11.24]
107389136  [KO:K04434]
107389324  fgf6; fibroblast growth factor 6 [KO:K04358]
107389325  [KO:K22428]
107389426  [KO:K04386]
107389464  [KO:K04353]
107389601  [KO:K04388] [EC:2.7.11.30]
107389642  [KO:K04407] [EC:2.7.11.1]
107389651  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
107389874  [KO:K05085] [EC:2.7.10.1]
107390001  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
107390011  [KO:K04424] [EC:2.7.11.25]
107390127  [KO:K04422] [EC:2.7.11.25]
107390181  mras; ras-related protein M-Ras [KO:K07831]
107390263  [KO:K04348] [EC:3.1.3.16]
107390339  epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
107390354  [KO:K04353]
107390383  [KO:K04465]
107390475  [KO:K04393]
107390498  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
107390617  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
107390716  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107390752  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107390818  [KO:K04441] [EC:2.7.11.24]
107390846  [KO:K04864]
107390862  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107390881  [KO:K04358]
107390894  [KO:K05084] [EC:2.7.10.1]
107390964  [KO:K02582]
107391001  [KO:K04860]
107391087  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107391092  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107391116  [KO:K04423] [EC:2.7.11.25]
107391168  [KO:K25416]
107391184  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
107391217  [KO:K04864]
107391292  [KO:K04441] [EC:2.7.11.24]
107391338  [KO:K04441] [EC:2.7.11.24]
107391375  [KO:K04856]
107391385  [KO:K05459]
107391407  [KO:K04853]
107391413  [KO:K07860]
107391452  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
107391483  [KO:K04375]
107391510  [KO:K18019] [EC:3.1.3.48]
107391531  [KO:K04437]
107391543  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
107391550  pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
107391584  [KO:K02677] [EC:2.7.11.13]
107391657  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
107391664  [KO:K04870]
107391665  [KO:K05094] [EC:2.7.10.1]
107391681  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
107391689  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
107391733  sos2; son of sevenless homolog 2 [KO:K03099]
107391734  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
107391809  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107391810  rras; ras-related protein R-Ras [KO:K07830]
107392009  [KO:K04445] [EC:2.7.11.1]
107392086  [KO:K05462]
107392096  [KO:K04410] [EC:2.7.11.1]
107392101  [KO:K04402]
107392214  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
107392312  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
107392368  [KO:K16859]
107392399  [KO:K04379]
107392404  tgfb3; transforming growth factor beta-3 [KO:K13377]
107392423  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
107392435  [KO:K04453]
107392461  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107392644  [KO:K04527] [EC:2.7.10.1]
107392711  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107392827  jund; transcription factor jun-D [KO:K04449]
107392870  [KO:K04372] [EC:2.7.11.1]
107392886  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
107393091  efna2; ephrin-A2 [KO:K05462]
107393104  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107393140  [KO:K04852]
107393236  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
107393294  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107393313  fgf22; fibroblast growth factor 22 [KO:K04358]
107393382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107393389  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
107393390  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107393427  pak2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
107393473  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107393481  [KO:K04348] [EC:3.1.3.16]
107393607  [KO:K04362] [EC:2.7.10.1]
107393790  [KO:K04378]
107393869  mef2c; myocyte-specific enhancer factor 2C [KO:K04454]
107393876  rasa1; ras GTPase-activating protein 1 [KO:K04352]
107394023  [KO:K05452]
107394032  ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
107394110  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
107394111  efna5; ephrin-A5 [KO:K05462]
107394133  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107394143  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
107394169  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
107394176  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107394259  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107394286  fgf10; fibroblast growth factor 10 [KO:K04358]
107394301  [KO:K09784]
107394302  [KO:K09782]
107394394  [KO:K04873]
107394397  [KO:K04872]
107394548  [KO:K04388] [EC:2.7.11.30]
107394598  [KO:K05462]
107394599  [KO:K05462]
107394670  [KO:K04373] [EC:2.7.11.1]
107394672  stk3; serine/threonine-protein kinase 3 [KO:K04412]
107394719  [KO:K04454]
107394749  [KO:K04362] [EC:2.7.10.1]
107394771  [KO:K04393]
107394854  daxx; death domain-associated protein 6 [KO:K02308]
107394905  [KO:K04446]
107394965  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
107394983  [KO:K04429] [EC:2.7.11.1]
107394986  [KO:K04468] [EC:2.7.11.24]
107395003  sos1; son of sevenless homolog 1 [KO:K03099]
107395004  [KO:K04860]
107395067  [KO:K04393]
107395144  [KO:K04358]
107395214  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107395364  fgf8; fibroblast growth factor 8 [KO:K04358]
107395449  [KO:K04456] [EC:2.7.11.1]
107395638  [KO:K07861]
107395645  [KO:K03173] [EC:2.3.2.27]
107395651  [KO:K03283]
107395761  [KO:K12326]
107395846  [KO:K04380]
107395867  angpt2; angiopoietin-2 [KO:K05466]
107395980  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107396012  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
107396136  [KO:K04358]
107396278  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
107396464  [KO:K04448]
107396466  [KO:K04389]
107396852  [KO:K05462]
107396907  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107396999  [KO:K05462]
107397053  [KO:K04441] [EC:2.7.11.24]
107397054  [KO:K04441] [EC:2.7.11.24]
107397055  crkl; crk-like protein [KO:K04438]
107397069  [KO:K04849]
107397194  [KO:K04456] [EC:2.7.11.1]
107397221  [KO:K05461]
107397236  [KO:K04438]
107397308  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
107397353  [KO:K04430] [EC:2.7.12.2]
107397381  [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
nfu04020  Calcium signaling pathway
nfu04070  Phosphatidylinositol signaling system
nfu04110  Cell cycle
nfu04115  p53 signaling pathway
nfu04210  Apoptosis
nfu04310  Wnt signaling pathway
KO pathway
ko04010   

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