KEGG   PATHWAY: ngi00260
Entry
ngi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ngi00260  Glycine, serine and threonine metabolism
ngi00260

Module
ngi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ngi00260]
ngi_M00047  Creatine pathway [PATH:ngi00260]
ngi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ngi00260]
ngi_M00555  Betaine biosynthesis, choline => betaine [PATH:ngi00260]
ngi_M00621  Glycine cleavage system [PATH:ngi00260]
ngi_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ngi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103747287  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
103742924  Shmt2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
103724826  Shmt1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
103730838  Agxt; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103745721  Grhpr; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
103747495  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
103733203  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
103734976  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
103737775  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
103726061  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
103732004  Phgdh; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
103749047  Psat1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
103738955  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
103748603  Gcat; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
103729977  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
103738665  Alas2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
103747456  Alas1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
103732590  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103742177  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
103735921  Aoc3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
103735920  Aoc2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
103732512  Gldc; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
103750185  Amt; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
103732169  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
103746689  Dao; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
103735910  Agxt2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
103746955  Gatm; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
103737328  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
103749026  Chdh; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
103740420  Aldh7a1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103750287  Bhmt; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:2.1.1.5]
103750305  Dmgdh; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
103730472  Pipox; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
103742819  Sardh; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
103730804  Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
103729336  Cbs; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
103744340  Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
103745538  Sdsl; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103745539  Sds; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103730526  Srr; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ngi00010  Glycolysis / Gluconeogenesis
ngi00020  Citrate cycle (TCA cycle)
ngi00230  Purine metabolism
ngi00250  Alanine, aspartate and glutamate metabolism
ngi00270  Cysteine and methionine metabolism
ngi00290  Valine, leucine and isoleucine biosynthesis
ngi00330  Arginine and proline metabolism
ngi00470  D-Amino acid metabolism
ngi00564  Glycerophospholipid metabolism
ngi00600  Sphingolipid metabolism
ngi00620  Pyruvate metabolism
ngi00630  Glyoxylate and dicarboxylate metabolism
ngi00640  Propanoate metabolism
ngi00860  Porphyrin metabolism
ngi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system