KEGG   PATHWAY: npd04350
Entry
npd04350                    Pathway                                
Name
TGF-beta signaling pathway - Nothoprocta perdicaria (Chilean tinamou)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
npd04350  TGF-beta signaling pathway
npd04350

Other DBs
GO: 0007179
Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112952390  CHRD; chordin [KO:K04657]
112953691  NOG; noggin [KO:K04658]
112951719  noggin-2-like [KO:K04658]
112959598  neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
112950685  GREM2; gremlin-2 [KO:K23318]
112958032  GREM1; gremlin-1 isoform X1 [KO:K23318]
112957975  THBS1; thrombospondin-1 [KO:K16857]
112944142  DCN; decorin [KO:K04660]
112959189  FMOD; fibromodulin [KO:K08121]
112942800  left-right determination factor 2-like [KO:K04668]
112944327  FST; follistatin isoform X1 [KO:K04661]
112958058  bone morphogenetic protein 7-like [KO:K21283]
112958934  BMP2; bone morphogenetic protein 2 [KO:K21283]
112943958  bone morphogenetic protein 2-like [KO:K21283]
112957780  BMP4; bone morphogenetic protein 4 [KO:K04662]
112952011  BMP6; bone morphogenetic protein 6 [KO:K16620]
112951682  INHBB; inhibin beta B chain [KO:K22687]
112944900  ovotransferrin-like [KO:K14736]
112943157  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
112949591  BMP7; bone morphogenetic protein 7 [KO:K16621]
112950870  bone morphogenetic protein 8A-like [KO:K16622]
112945683  GDF5; growth/differentiation factor 5 isoform X1 [KO:K04664]
112956487  GDF6; growth/differentiation factor 6 [KO:K20012]
112952092  GDF7; growth/differentiation factor 7 [KO:K20013]
112952698  AMH; muellerian-inhibiting factor [KO:K04665]
112958855  IFNG; interferon gamma [KO:K04687]
112959056  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
112952771  FBN1; fibrillin-1 [KO:K06825]
112957518  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
112955150  TGFB2; transforming growth factor beta-2 [KO:K13376]
112958062  TGFB3; transforming growth factor beta-3 [KO:K13377]
112943746  INHBA; LOW QUALITY PROTEIN: inhibin beta A chain [KO:K04667]
112952252  inhibin beta C chain-like [KO:K22688]
112952276  inhibin beta C chain-like [KO:K22689]
112950158  nodal homolog 2-A-like [KO:K04666]
112950486  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
112949366  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
112946371  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
112956236  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
112948612  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
112950617  HJV; hemojuvelin [KO:K23100]
112951000  NEO1; neogenin [KO:K06766]
112952421  TFRC; transferrin receptor protein 1 [KO:K06503]
112948303  RGMA; repulsive guidance molecule A [KO:K23096]
112951403  RGMB; RGM domain family member B [KO:K06847]
112952282  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
112953156  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112954963  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
112952606  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112943377  LRRC32; leucine-rich repeat-containing protein 32 [KO:K26316]
112960400  leucine-rich repeat-containing protein 32-like [KO:K26316]
112944875  NRROS; negative regulator of reactive oxygen species [KO:K26317]
112950321  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
112958098  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
112946356  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
112955475  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
112950148  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
112954272  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
112942894  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
112947301  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
112948290  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
112947233  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112948386  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
112952997  mothers against decapentaplegic homolog 6-like [KO:K04677]
112947736  SMAD7; mothers against decapentaplegic homolog 7 [KO:K19631]
112959817  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
112953758  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
112943113  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
112944576  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
112946469  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
112942705  CUL1; cullin-1 [KO:K03347]
112952406  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112953407  RHOA; transforming protein RhoA [KO:K04513]
112944131  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
112953464  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112952396  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112954566  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112957576  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112949545  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
112945488  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
112951868  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
112953932  ID4; DNA-binding protein inhibitor ID-4 isoform X1 [KO:K17695]
112945662  RBL1; retinoblastoma-like protein 1 [KO:K04681]
112960333  E2F5; transcription factor E2F5 [KO:K04682]
112955299  E2F4; transcription factor E2F4 [KO:K04682]
112953182  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
112955675  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112946445  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112952281  SP1; transcription factor Sp1 [KO:K04684]
112952558  SKIL; ski-like protein [KO:K18499]
112957387  SKI; ski oncogene isoform X1 [KO:K26503]
112958763  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
112949373  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112950748  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
112945402  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
112944115  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
112945690  TGIF2; homeobox protein TGIF2 [KO:K19553]
112959422  MYC; myc proto-oncogene protein [KO:K04377]
112944410  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
112951378  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
112957284  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
npd04010  MAPK signaling pathway
npd04110  Cell cycle
npd04120  Ubiquitin mediated proteolysis
npd04210  Apoptosis
KO pathway
ko04350   
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