KEGG   PATHWAY: oki04146
Entry
oki04146                    Pathway                                
Name
Peroxisome - Oncorhynchus kisutch (coho salmon)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
oki04146  Peroxisome
oki04146

Other DBs
GO: 0005777
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109881813  peroxisomal membrane protein PEX16 isoform X1 [KO:K13335]
116359590  peroxisomal membrane protein PEX16-like isoform X1 [KO:K13335]
109900758  pex3; peroxisomal biogenesis factor 3 [KO:K13336]
109872081  peroxisomal biogenesis factor 19-like isoform X1 [KO:K13337]
109874939  peroxisomal biogenesis factor 19 [KO:K13337]
109909968  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
109871874  ATP-binding cassette sub-family D member 3 isoform X2 [KO:K05677] [EC:7.6.2.4]
109875785  ATP-binding cassette sub-family D member 3 [KO:K05677] [EC:7.6.2.4]
109874906  ATP-binding cassette sub-family D member 3-like isoform X3 [KO:K05677] [EC:7.6.2.4]
109903391  pex1; peroxisome biogenesis factor 1 [KO:K13338]
109890209  pex6; peroxisome biogenesis factor 6 [KO:K13339]
109896610  peroxisome assembly protein 26 isoform X1 [KO:K13340]
109866646  pex7; peroxisomal biogenesis factor 7 [KO:K13341]
109910270  pex5; peroxisomal biogenesis factor 5 isoform X2 [KO:K13342]
109888508  PEX5-related protein isoform X1 [KO:K13342]
109875373  PEX5-related protein-like isoform X1 [KO:K13342]
109902179  peroxisomal targeting signal 1 receptor-like isoform X2 [KO:K13342]
109902931  PEX5-related protein [KO:K13342]
109908029  pex14; peroxisomal membrane protein PEX14 [KO:K13343]
109876043  peroxisomal membrane protein PEX13-like isoform X1 [KO:K13344]
109876346  peroxisomal membrane protein PEX13-like isoform X1 [KO:K13344]
109873241  pex12; peroxisome assembly protein 12 [KO:K13345]
109869654  pex10; LOW QUALITY PROTEIN: peroxisome biogenesis factor 10 [KO:K13346]
109876514  peroxisome biogenesis factor 10 [KO:K13346]
109878546  pex2; peroxisome biogenesis factor 2 [KO:K06664]
109895974  pxmp2; peroxisomal membrane protein 2 isoform X1 [KO:K13347]
109889119  mpv17-like protein 2 [KO:K13348]
109866148  mpv17; protein Mpv17 isoform X1 [KO:K13348]
109883200  mpv17-like protein [KO:K13349]
109886153  mpv17-like protein [KO:K13349]
109876376  mpv17-like protein [KO:K13349]
116363543  mpv17-like protein [KO:K13349]
109885953  mpv17-like protein [KO:K13349]
109886260  mpv17-like protein [KO:K13349]
109890302  pxmp4; peroxisomal membrane protein 4 [KO:K13350]
109889387  pex11a; peroxisomal membrane protein 11A [KO:K13351]
109875846  peroxisomal membrane protein 11B [KO:K13352]
109907451  peroxisomal membrane protein 11B-like [KO:K13352]
109889134  pex11g; peroxisomal membrane protein 11C isoform X1 [KO:K13353]
109876958  peroxisomal membrane protein PMP34 isoform X1 [KO:K13354]
109898274  peroxisomal membrane protein PMP34 isoform X2 [KO:K13354]
109891882  peroxisomal membrane protein PMP34-like [KO:K13354]
109876961  2-hydroxyacyl-CoA lyase 1 isoform X1 [KO:K12261] [EC:4.1.2.63]
116365063  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
109868013  amacr; alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
109910359  phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
109879966  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
109875945  peroxisomal acyl-coenzyme A oxidase 1-like isoform X1 [KO:K00232] [EC:1.3.3.6]
109896850  acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
109865721  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
109875358  hsd17b4; peroxisomal multifunctional enzyme type 2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
109874803  scp2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:2.3.1.176]
109894173  acyl-coenzyme A thioesterase 1-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
109882746  ehhadh; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
109880058  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
109865927  decr2; peroxisomal 2,4-dienoyl-CoA reductase isoform X1 [KO:K13237] [EC:1.3.1.124]
109905550  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
109880242  ATP-binding cassette sub-family D member 1 [KO:K05675] [EC:7.6.2.4]
109896818  abcd2; ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
109864383  ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
109879625  abcd4; ATP-binding cassette sub-family D member 4 isoform X1 [KO:K05678] [EC:7.6.2.8]
109882243  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
109882237  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
116359628  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
109882236  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
109897683  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
109905002  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
109875652  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
109878598  long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
109892959  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
109892650  long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
109871973  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109872242  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109901038  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X2 [KO:K01897] [EC:6.2.1.3]
109872828  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
109882820  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109894210  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109865554  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
109875162  long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
109895876  long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
109879175  pecr; peroxisomal trans-2-enoyl-CoA reductase [KO:K07753] [EC:1.3.1.38]
109875878  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
109908747  eci2; enoyl-CoA delta isomerase 2, mitochondrial [KO:K13239] [EC:5.3.3.8]
109867636  nudt7; peroxisomal coenzyme A diphosphatase NUDT7 isoform X1 [KO:K17879] [EC:3.6.1.77]
109865368  nudt13; nucleoside diphosphate-linked moiety X motif 13 isoform X1 [KO:K03426] [EC:3.6.1.22]
109884514  nudt12; peroxisomal NADH pyrophosphatase NUDT12 isoform X1 [KO:K03426] [EC:3.6.1.22]
109881604  nucleoside diphosphate-linked moiety X motif 19 [KO:K13355] [EC:3.6.1.77]
109901326  acot8; acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
109868459  crat; carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
109878836  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
109903733  carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
109895836  carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
109905745  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
116352987  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
109884780  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
109889306  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
109866929  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
109900742  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
109885185  dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
109870994  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X3 [KO:K00803] [EC:2.5.1.26]
109866908  agps; alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1 [KO:K00803] [EC:2.5.1.26]
109889587  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
109884014  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
109880583  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
109867227  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
109871508  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
109895662  mvk; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
109908131  pmvk; phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
109881853  agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
109875060  serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
109895969  dao; D-amino-acid oxidase isoform X4 [KO:K00273] [EC:1.4.3.3]
109904296  ddo; D-aspartate oxidase isoform X2 [KO:K00272] [EC:1.4.3.1]
109867781  isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
109889376  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
109877235  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
109881709  isocitrate dehydrogenase [NADP] cytoplasmic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
116362575  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
109867279  idh2; isocitrate dehydrogenase [NADP], mitochondrial isoform X1 [KO:K00031] [EC:1.1.1.42]
109889726  paox; peroxisomal N(1)-acetyl-spermine/spermidine oxidase [KO:K00308] [EC:1.5.3.13]
109909225  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
109870369  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic-like [KO:K01640] [EC:4.1.3.4]
109899863  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic-like isoform X1 [KO:K01640] [EC:4.1.3.4]
109894591  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
109903957  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
109871358  hydroxyacid oxidase 2 isoform X1 [KO:K11517] [EC:1.1.3.15]
109903081  hydroxyacid oxidase 2-like isoform X8 [KO:K11517] [EC:1.1.3.15]
109904137  hao1; hydroxyacid oxidase 1 isoform X2 [KO:K11517] [EC:1.1.3.15]
109889977  catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
109865651  catalase-like [KO:K03781] [EC:1.11.1.6]
109867216  catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
109872940  peroxiredoxin-5, mitochondrial-like isoform X1 [KO:K11187] [EC:1.11.1.24]
109874126  peroxiredoxin-5, mitochondrial [KO:K11187] [EC:1.11.1.24]
109880474  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
109885306  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
109900990  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
109909545  nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
109906100  nitric oxide synthase, inducible-like [KO:K13241] [EC:1.14.13.39]
109892271  peroxiredoxin-like isoform X1 [KO:K13279] [EC:1.11.1.24]
109871776  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
109865858  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
109865838  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
109874517  peroxiredoxin [KO:K13279] [EC:1.11.1.24]
109904342  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
109893829  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
109868238  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
109879286  glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
109884874  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109896965  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
109906430  dehydrogenase/reductase SDR family member 4 isoform X2 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
oki00071  Fatty acid degradation
oki00120  Primary bile acid biosynthesis
oki00230  Purine metabolism
oki00564  Glycerophospholipid metabolism
oki00565  Ether lipid metabolism
oki00830  Retinol metabolism
oki00900  Terpenoid backbone biosynthesis
oki03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

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