KEGG   PATHWAY: omy00260
Entry
omy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Oncorhynchus mykiss (rainbow trout)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
omy00260  Glycine, serine and threonine metabolism
omy00260

Module
omy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:omy00260]
omy_M00047  Creatine pathway [PATH:omy00260]
omy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:omy00260]
omy_M00555  Betaine biosynthesis, choline => betaine [PATH:omy00260]
omy_M00621  Glycine cleavage system [PATH:omy00260]
omy_M00974  Betaine metabolism, animals, betaine => glycine [PATH:omy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Oncorhynchus mykiss (rainbow trout) [GN:omy]
Gene
110502854  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
110494773  shmt2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
110514212  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
110514494  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
110530082  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b isoform X2 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110525913  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110488715  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110513528  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110504913  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110517888  glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110494647  glycerate kinase [KO:K11529] [EC:2.7.1.165]
110502667  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110509748  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
110523533  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
110499339  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110493407  pgam1b; phosphoglycerate mutase 1 isoform X1 [KO:K01834] [EC:5.4.2.11]
118940026  phosphoglycerate mutase 1 isoform X1 [KO:K01834] [EC:5.4.2.11]
110524766  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
110500043  bisphosphoglycerate mutase isoform X1 [KO:K01837] [EC:5.4.2.4 5.4.2.11]
110501470  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110520091  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110536504  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
110503884  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
110507713  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
110486537  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
110529158  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
110504320  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
110498016  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
110521122  tdh; L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
110494837  5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
110528663  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
110492405  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
110532218  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
100136729  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
110523651  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
110501356  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
110538408  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
110486385  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
110535832  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
110525447  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
118965936  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
110492324  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
110521345  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110492846  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110521627  glycine cleavage system H protein, mitochondrial [KO:K02437]
110496216  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
110506512  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
110526391  glycine cleavage system H protein, mitochondrial isoform X2 [KO:K02437]
110536118  D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
110536779  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110509504  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
110509505  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
110495805  guanidinoacetate N-methyltransferase-like isoform X1 [KO:K00542] [EC:2.1.1.2]
110524165  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
110532065  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
110523197  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110509664  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
110523446  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
110523447  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
110504053  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110523941  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
110506251  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
110502018  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
100136726  cbs; cystathionine-beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
110496973  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
110520495  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
110524183  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
110498361  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
110502325  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
110526991  serine racemase-like [KO:K01754] [EC:4.3.1.19]
110536048  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110497718  sdsl; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110525680  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110530868  zgc:162816; D-threo-3-hydroxyaspartate dehydratase isoform X1 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
omy00010  Glycolysis / Gluconeogenesis
omy00020  Citrate cycle (TCA cycle)
omy00230  Purine metabolism
omy00250  Alanine, aspartate and glutamate metabolism
omy00270  Cysteine and methionine metabolism
omy00290  Valine, leucine and isoleucine biosynthesis
omy00330  Arginine and proline metabolism
omy00470  D-Amino acid metabolism
omy00564  Glycerophospholipid metabolism
omy00600  Sphingolipid metabolism
omy00620  Pyruvate metabolism
omy00630  Glyoxylate and dicarboxylate metabolism
omy00640  Propanoate metabolism
omy00860  Porphyrin metabolism
omy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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