Entry
Name
GABAergic synapse - Papio anubis (olive baboon)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Papio anubis (olive baboon) [GN:
panu ]
Gene
101015396 SLC38A1; sodium-coupled neutral amino acid transporter 1 isoform X1 [KO:K14990 ]
101018614 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207 ]
101024782 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X6 [KO:K05175 ]
116272845 gamma-aminobutyric acid receptor subunit alpha-5-like [KO:K05175 ]
101003983 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175 ]
101004333 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175 ]
101019293 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175 ]
101026187 GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175 ]
100997552 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181 ]
101003052 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181 ]
101019861 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181 ]
101021381 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186 ]
101005608 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X2 [KO:K05186 ]
101024421 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186 ]
101018968 GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184 ]
101025991 GABRE; gamma-aminobutyric acid receptor subunit epsilon isoform X1 [KO:K05185 ]
100999093 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
101021843 HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647 ]
101011002 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
101020446 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X4 [KO:K08341 ]
101025519 GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
101010523 TRAK2; trafficking kinesin-binding protein 2 isoform X2 [KO:K15374 ]
101024372 PLCL1; inactive phospholipase C-like protein 1 isoform X1 [KO:K15375 ]
101007463 SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967 ]
101004305 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
101015883 GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190 ]
101003252 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190 ]
101013922 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
101026237 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X7 [KO:K04850 ]
101002070 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X6 [KO:K04851 ]
101019865 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
101025213 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
101011518 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615 ]
101021210 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615 ]
101011013 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
101011251 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
101020528 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
101018328 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534 ]
101016713 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536 ]
101017982 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
100997846 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
101003812 GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538 ]
101004338 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
116275838 guanine nucleotide-binding protein subunit beta-5-like [KO:K04539 ]
101011441 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
101009143 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
101024158 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
100997854 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
101000991 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
101012463 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
108583299 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
101004170 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
101006936 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
101015176 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
101008105 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
101021341 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
101007744 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
101020753 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
101014556 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046 ]
101021084 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
101013834 SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045 ]
101012207 SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
101003633 SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X2 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
panu00250 Alanine, aspartate and glutamate metabolism
KO pathway
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