KEGG   PATHWAY: panu04144
Entry
panu04144                   Pathway                                
Name
Endocytosis - Papio anubis (olive baboon)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
panu04144  Endocytosis
panu04144

Other DBs
GO: 0006897
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101000843  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101024648  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101026303  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
100137415  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101003235  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
101018997  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101017925  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
101026381  DNM3; dynamin-3 isoform X4 [KO:K01528] [EC:3.6.5.5]
101004866  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
100999429  DNM2; dynamin-2 isoform X9 [KO:K23484] [EC:3.6.5.5]
101010676  CLTA; clathrin light chain A isoform X1 [KO:K04644]
101015474  CLTB; LOW QUALITY PROTEIN: clathrin light chain B [KO:K04645]
101017523  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101022293  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101016499  AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101016056  AP2A1; AP-2 complex subunit alpha-1 isoform X2 [KO:K11824]
101020304  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101008695  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
101014753  AP2S1; AP-2 complex subunit sigma isoform X2 [KO:K11827]
100998271  EHD2; EH domain-containing protein 2 [KO:K12469]
101016512  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101023107  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101001297  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
101008435  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101019999  PML; protein PML isoform X4 [KO:K10054] [EC:2.3.2.-]
101004882  SMAD2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100999281  TFRC; transferrin receptor protein 1 [KO:K06503]
101003588  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101022081  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101002495  FGFR2; fibroblast growth factor receptor 2 isoform X12 [KO:K05093] [EC:2.7.10.1]
101014560  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101025157  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100126735  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101005565  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
101011142  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101017356  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
101022676  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X10 [KO:K12470]
101005109  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
101026093  SH3GL3; endophilin-A3 isoform X2 [KO:K11247]
101008251  SH3GL1; endophilin-A2 isoform X2 [KO:K11247]
101009352  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
101023943  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
101001240  BIN1; myc box-dependent-interacting protein 1 isoform X28 [KO:K12562]
101005807  AMPH; amphiphysin isoform X1 [KO:K12562]
101010559  EPN3; epsin-3 isoform X1 [KO:K12471]
100998482  EPN2; epsin-2 isoform X2 [KO:K12471]
100998384  EPN1; epsin-1 isoform X1 [KO:K12471]
101001580  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
101018193  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X7 [KO:K12472]
101002679  SPART; spartin [KO:K19366]
101016432  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116272920  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
101005585  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X17 [KO:K13305] [EC:2.3.2.26]
101016712  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101002649  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101004944  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X3 [KO:K11981] [EC:2.3.2.27]
101020727  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X3 [KO:K05632] [EC:2.3.2.26]
101016514  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
101009397  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
100998869  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
101016912  LDLR; low-density lipoprotein receptor [KO:K12473]
101002864  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X3 [KO:K12474]
101010586  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
100126710  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101017773  CXCR1; C-X-C chemokine receptor type 1 isoform X1 [KO:K04175]
101017180  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
103876540  C-X-C chemokine receptor type 2-like [KO:K05050]
100126711  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101022757  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100999299  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101003424  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
101017434  GRK2; beta-adrenergic receptor kinase 1 isoform X3 [KO:K00910] [EC:2.7.11.15]
101025057  GRK5; G protein-coupled receptor kinase 5 isoform X3 [KO:K08291] [EC:2.7.11.16]
101000030  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101001106  GRK4; G protein-coupled receptor kinase 4 isoform X13 [KO:K08291] [EC:2.7.11.16]
101000328  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101014965  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
101001611  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
101000314  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
101011267  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101002644  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
101019379  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
101021211  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
101019552  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X6 [KO:K05758]
101022717  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
100137560  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101005664  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101018343  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101018299  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
101005427  WIPF1; WAS/WASL-interacting protein family member 1 isoform X2 [KO:K19475]
101003590  WAS/WASL-interacting protein family member 3 [KO:K19475]
116274631  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
101009582  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101024987  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101005304  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
101021909  WASHC4; WASH complex subunit 4 isoform X2 [KO:K18465]
101025182  WASHC5; WASH complex subunit 5 [KO:K18464]
101012398  WASHC1; WASH complex subunit 1 isoform X2 [KO:K18461]
101008664  WASHC3; WASH complex subunit 3 isoform X3 [KO:K18463]
101009575  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100999354  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100126673  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101011470  CAPZB; F-actin-capping protein subunit beta isoform X5 [KO:K10365]
101023429  VPS29; vacuolar protein sorting-associated protein 29 isoform X3 [KO:K18467]
101018648  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
100997365  VPS26A; vacuolar protein sorting-associated protein 26A isoform X2 [KO:K18466]
101011892  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
116275386  sorting nexin-3 isoform X1 [KO:K17918]
116275388  sorting nexin-3 isoform X1 [KO:K17918]
100137455  SNX3; sorting nexin-3 [KO:K17918]
101006980  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
110741017  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
101006348  RAB7A; ras-related protein Rab-7a [KO:K07897]
101000472  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101023435  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101010387  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101001247  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
101017212  MVB12B; multivesicular body subunit 12B isoform X5 [KO:K12186]
100997362  MVB12A; multivesicular body subunit 12A [KO:K12186]
101021403  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
101005539  VPS37B; vacuolar protein sorting-associated protein 37B isoform X2 [KO:K12185]
101012574  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
101003808  VPS37C; vacuolar protein sorting-associated protein 37C isoform X2 [KO:K12185]
101004465  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
101020419  SNF8; vacuolar-sorting protein SNF8 isoform X2 [KO:K12188]
101011058  VPS25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
101023361  CHMP6; charged multivesicular body protein 6 isoform X2 [KO:K12195]
103875482  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
100997370  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
101017392  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101000776  CHMP3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
101015580  CHMP2A; charged multivesicular body protein 2a isoform X2 [KO:K12191]
100999632  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101005162  CHMP7; charged multivesicular body protein 7 isoform X2 [KO:K15053]
116271491  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
100997079  vacuolar protein sorting-associated protein 4B [KO:K12196]
101007665  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
101018056  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
101018904  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101016796  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
101022982  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101022566  IST1; IST1 homolog isoform X1 [KO:K19476]
101007873  programmed cell death 6-interacting protein isoform X2 [KO:K12200]
116273849  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
116273852  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
100997572  SPG21; maspardin [KO:K19367]
101005933  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101012834  SNX2; sorting nexin-2 isoform X2 [KO:K17917]
101020449  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
101013389  SNX32; sorting nexin-32 isoform X2 [KO:K17920]
101020471  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
116268483  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
100137366  SNX6; sorting nexin-6 [KO:K17920]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101004576  IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068]
101014683  IL2RB; interleukin-2 receptor subunit beta isoform X4 [KO:K05069]
101008968  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101021987  HLA class I histocompatibility antigen, B-27 alpha chain isoform X1 [KO:K06751]
101019755  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-38 alpha chain [KO:K06751]
101025045  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
116272574  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100997583  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
116272784  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101022333  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101003522  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101021633  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101006198  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
116268677  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
116272937  HLA class I histocompatibility antigen, Cw-6 alpha chain-like isoform X1 [KO:K06751]
101012738  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
101026217  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101002482  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
116273056  HLA class I histocompatibility antigen, Cw-8 alpha chain-like isoform X1 [KO:K06751]
116273133  HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
116273134  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101020363  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101021052  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101024059  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E [KO:K06751]
101015220  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751]
101009503  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
100126713  PACA-F; major histocompatibility complex, class I, F precursor [KO:K06751]
101007932  patr class I histocompatibility antigen, A-126 alpha chain-like precursor [KO:K06751]
116269732  folate receptor beta [KO:K13649]
101000220  FOLR3; folate receptor gamma isoform X1 [KO:K13649]
101001135  FOLR1; folate receptor alpha [KO:K13649]
101000788  folate receptor gamma-like [KO:K13649]
100126666  CAV1; caveolin-1 [KO:K06278]
100126667  CAV2; caveolin-2 [KO:K12958]
101009939  CAV3; caveolin-3 [KO:K12959]
101024493  EHD3; EH domain-containing protein 3 [KO:K12476]
101000731  EHD4; EH domain-containing protein 4 [KO:K12477]
101022009  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100999279  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101027064  RAB5B; ras-related protein Rab-5B [KO:K07888]
103878847  RAB5C; ras-related protein Rab-5C [KO:K07889]
100999174  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
101014208  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
101019570  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
101016304  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
101001327  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
100137473  EHD1; EH domain-containing protein 1 [KO:K12483]
101011238  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101023095  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
101022789  RAB31; ras-related protein Rab-31 [KO:K07891]
101012996  RAB22A; ras-related protein Rab-22A [KO:K07891]
101016609  RAB10; ras-related protein Rab-10 [KO:K07903]
101014385  RAB8A; ras-related protein Rab-8A [KO:K07901]
101006908  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
101005850  RAB11A; ras-related protein Rab-11A [KO:K07904]
101024073  RAB11B; ras-related protein Rab-11B [KO:K07905]
101005550  RAB11FIP5; rab11 family-interacting protein 5 isoform X5 [KO:K12484]
100997473  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
101017050  RAB11FIP2; rab11 family-interacting protein 2 isoform X2 [KO:K12484]
101017160  ZFYVE27; protrudin isoform X1 [KO:K19368]
101002273  KIF5A; kinesin heavy chain [KO:K10396]
101014566  KIF5C; kinesin heavy chain [KO:K10396]
101002261  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
101020531  RAB11FIP4; rab11 family-interacting protein 4 isoform X2 [KO:K12485]
101007578  PARD3; partitioning defective 3 homolog isoform X9 [KO:K04237]
101003483  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101019858  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
101006674  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101020378  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101025097  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101004833  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101007713  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
101007528  SMAP1; stromal membrane-associated protein 1 isoform X2 [KO:K12486]
101010685  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101016347  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
101023430  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
101005631  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
101023214  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
101005069  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
101025946  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K12489]
101013666  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
101006258  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X13 [KO:K18439]
101022306  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
101001754  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101006217  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like [KO:K12491]
103881574  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like [KO:K12491]
101000696  AGAP3; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
101016116  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
101007472  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
101015277  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X3 [KO:K12492]
100999159  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
101020955  ARFGAP3; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
100999878  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
101021521  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
101000961  PSD2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
101010487  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
101013489  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
101004970  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X4 [KO:K12495]
101009534  IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
101002659  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101009174  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
101016830  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
101008736  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
101003174  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X2 [KO:K18442]
101018240  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
101020023  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8 [KO:K18443]
101026489  ARF1; ADP-ribosylation factor 1 [KO:K07937]
103878897  LOW QUALITY PROTEIN: ADP-ribosylation factor 2 [KO:K07937]
101011120  ARF3; ADP-ribosylation factor 3 [KO:K07938]
101017080  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
100137392  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
panu04060  Cytokine-cytokine receptor interaction
panu04070  Phosphatidylinositol signaling system
panu04130  SNARE interactions in vesicular transport
panu04142  Lysosome
panu04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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