KEGG   PATHWAY: pbi00830
Entry
pbi00830                    Pathway                                
Name
Retinol metabolism - Python bivittatus (Burmese python)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pbi00830  Retinol metabolism
pbi00830

Other DBs
GO: 0006776
Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103066232  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
103066617  alcohol dehydrogenase 1B-like [KO:K13951] [EC:1.1.1.1]
103066859  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
103067257  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
103067637  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
103054360  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
103056418  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
103061486  DHRS9; dehydrogenase/reductase SDR family member 9 isoform X2 [KO:K11149] [EC:1.1.-.-]
103058237  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
103051172  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
103068234  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
103055029  LOW QUALITY PROTEIN: retinol dehydrogenase 12-like [KO:K11153] [EC:1.1.1.300]
103062275  retinol dehydrogenase 16-like [KO:K11154] [EC:1.1.1.-]
103065145  retinol dehydrogenase 16-like [KO:K11154] [EC:1.1.1.-]
103066025  retinol dehydrogenase 16-like [KO:K11154] [EC:1.1.1.-]
103063029  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
103063622  17-beta-hydroxysteroid dehydrogenase type 6-like [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
103061458  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
103065772  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
103052521  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X2 [KO:K11157] [EC:3.1.1.-]
103048404  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
103065660  RDH5; 11-cis retinol dehydrogenase [KO:K00061] [EC:1.1.1.315]
103048615  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
103057171  ALDH1A1; retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
103055946  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
103056376  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
103064486  cytochrome P450 26A1-like [KO:K07437] [EC:1.14.14.-]
103052492  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
103066292  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
103054127  cytochrome P450 2C5-like [KO:K07413] [EC:1.14.14.1]
103067414  cytochrome P450 2B4-like isoform X1 [KO:K07413] [EC:1.14.14.1]
103050164  cytochrome P450 3A9-like [KO:K07424] [EC:1.14.14.1]
103050666  cytochrome P450 3A29-like [KO:K07424] [EC:1.14.14.1]
103060913  cytochrome P450 2W1-like [KO:K07423] [EC:1.14.14.-]
103061481  cytochrome P450 2W1-like [KO:K07423] [EC:1.14.14.-]
103068173  UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
103057215  UGT2A2; UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
103048791  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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