KEGG   PATHWAY: pcoo03040
Entry
pcoo03040                   Pathway                                
Name
Spliceosome - Puma concolor (puma)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pcoo03040  Spliceosome
pcoo03040

Other DBs
GO: 0005681
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112850603  U1 spliceosomal RNA [KO:K14276]
112855795  U1 spliceosomal RNA [KO:K14276]
112849183  U1 spliceosomal RNA [KO:K14276]
112859201  U1 spliceosomal RNA [KO:K14276]
112855879  U1 spliceosomal RNA [KO:K14276]
112861890  U1 spliceosomal RNA [KO:K14276]
112856610  U1 spliceosomal RNA [KO:K14276]
112866244  U1 spliceosomal RNA [KO:K14276]
112856633  U1 spliceosomal RNA [KO:K14276]
112859202  U1 spliceosomal RNA [KO:K14276]
112849184  U1 spliceosomal RNA [KO:K14276]
112856621  U1 spliceosomal RNA [KO:K14276]
112863973  U1 spliceosomal RNA [KO:K14276]
112854217  U2 spliceosomal RNA [KO:K14277]
112857434  U2 spliceosomal RNA [KO:K14277]
112871718  U2 spliceosomal RNA [KO:K14277]
112870545  U2 spliceosomal RNA [KO:K14277]
112852222  U2 spliceosomal RNA [KO:K14277]
112850638  U2 spliceosomal RNA [KO:K14277]
112854915  U2 spliceosomal RNA [KO:K14277]
112854230  U2 spliceosomal RNA [KO:K14277]
112854227  U2 spliceosomal RNA [KO:K14277]
112871719  U2 spliceosomal RNA [KO:K14277]
112849199  U2 spliceosomal RNA [KO:K14277]
112854228  U2 spliceosomal RNA [KO:K14277]
112870528  U4 spliceosomal RNA [KO:K14278]
112859228  U4 spliceosomal RNA [KO:K14278]
112851566  U4 spliceosomal RNA [KO:K14278]
112849000  U4 spliceosomal RNA [KO:K14278]
112863042  U4 spliceosomal RNA [KO:K14278]
112871396  U4 spliceosomal RNA [KO:K14278]
112856764  U4 spliceosomal RNA [KO:K14278]
112870527  U4 spliceosomal RNA [KO:K14278]
112868741  U4 spliceosomal RNA [KO:K14278]
112856519  U5 spliceosomal RNA [KO:K14279]
112849011  U5 spliceosomal RNA [KO:K14279]
112856520  U5 spliceosomal RNA [KO:K14279]
112849010  U5 spliceosomal RNA [KO:K14279]
112849017  U6 spliceosomal RNA [KO:K14280]
112853068  U6 spliceosomal RNA [KO:K14280]
112856525  U6 spliceosomal RNA [KO:K14280]
112868074  U6 spliceosomal RNA [KO:K14280]
112851615  U6 spliceosomal RNA [KO:K14280]
112868469  U6 spliceosomal RNA [KO:K14280]
112849030  U6 spliceosomal RNA [KO:K14280]
112857598  U6 spliceosomal RNA [KO:K14280]
112869783  U6 spliceosomal RNA [KO:K14280]
112867146  U6 spliceosomal RNA [KO:K14280]
112868466  U6 spliceosomal RNA [KO:K14280]
112861759  U6 spliceosomal RNA [KO:K14280]
112861762  U6 spliceosomal RNA [KO:K14280]
112850528  U6 spliceosomal RNA [KO:K14280]
112861763  U6 spliceosomal RNA [KO:K14280]
112849013  U6 spliceosomal RNA [KO:K14280]
112871402  U6 spliceosomal RNA [KO:K14280]
112861769  U6 spliceosomal RNA [KO:K14280]
112866274  U6 spliceosomal RNA [KO:K14280]
112863054  U6 spliceosomal RNA [KO:K14280]
112862953  U6 spliceosomal RNA [KO:K14280]
112868078  U6 spliceosomal RNA [KO:K14280]
112871418  U6 spliceosomal RNA [KO:K14280]
112859119  U6 spliceosomal RNA [KO:K14280]
112863999  U6 spliceosomal RNA [KO:K14280]
112849016  U6 spliceosomal RNA [KO:K14280]
112853816  U6 spliceosomal RNA [KO:K14280]
112856534  U6 spliceosomal RNA [KO:K14280]
112863046  U6 spliceosomal RNA [KO:K14280]
112859812  U6 spliceosomal RNA [KO:K14280]
112871400  U6 spliceosomal RNA [KO:K14280]
112859109  U6 spliceosomal RNA [KO:K14280]
112864738  U6 spliceosomal RNA [KO:K14280]
112859505  U6 spliceosomal RNA [KO:K14280]
112854922  U6 spliceosomal RNA [KO:K14280]
112859512  U6 spliceosomal RNA [KO:K14280]
112868073  U6 spliceosomal RNA [KO:K14280]
112857962  U6 spliceosomal RNA [KO:K14280]
112859518  U6 spliceosomal RNA [KO:K14280]
112850657  U6 spliceosomal RNA [KO:K14280]
112855726  U6 spliceosomal RNA [KO:K14280]
112856536  U6 spliceosomal RNA [KO:K14280]
112849018  U6 spliceosomal RNA [KO:K14280]
112861773  U6 spliceosomal RNA [KO:K14280]
112850564  U6 spliceosomal RNA [KO:K14280]
112863048  U6 spliceosomal RNA [KO:K14280]
112871409  U6 spliceosomal RNA [KO:K14280]
112870069  U6 spliceosomal RNA [KO:K14280]
112861758  U6 spliceosomal RNA [KO:K14280]
112867150  U6 spliceosomal RNA [KO:K14280]
112849039  U6 spliceosomal RNA [KO:K14280]
112867137  U6 spliceosomal RNA [KO:K14280]
112856578  U6 spliceosomal RNA [KO:K14280]
112861778  U6 spliceosomal RNA [KO:K14280]
112856533  U6 spliceosomal RNA [KO:K14280]
112860253  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
112853421  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
112853427  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
112857345  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
112862023  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
112867302  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
112853961  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
112860348  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
112858661  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
112868952  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
112868300  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
112851077  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
112870202  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
112858975  small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
112857747  SNRPE; small nuclear ribonucleoprotein E isoform X1 [KO:K11097]
112856124  small nuclear ribonucleoprotein F-like [KO:K11098]
112863656  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
112868943  SNRPG; small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
112850793  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
112851072  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
112862843  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
112867363  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
112848810  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
112855291  RBM25; RNA-binding protein 25 [KO:K12822]
112864676  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
112861710  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
112856824  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
112855395  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
112868921  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
112870187  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
112852791  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
112871526  SF3A3; splicing factor 3A subunit 3 isoform X1 [KO:K12827]
112848744  SF3B1; splicing factor 3B subunit 1 [KO:K12828]
112852003  SF3B2; splicing factor 3B subunit 2 [KO:K12829]
112857334  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
112848471  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
112862259  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
112864182  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
112863487  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
112864640  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
112849523  U2AF1; LOW QUALITY PROTEIN: splicing factor U2AF 35 kDa subunit [KO:K12836]
112851045  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
112850943  U2AF2; splicing factor U2AF 65 kDa subunit [KO:K12837]
112859603  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
112854507  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
112867359  RBM17; splicing factor 45 [KO:K12840]
112849410  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
112866381  RP9; retinitis pigmentosa 9 protein [KO:K19604]
112853624  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
112858379  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
112866743  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
112858486  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
112872035  PRPF3; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
112868538  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
112871810  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
112851115  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
112863520  SNU13; NHP2-like protein 1 isoform X1 [KO:K12845]
112869100  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
112868924  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
112851950  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
112860310  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
112863659  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
112871987  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
112853970  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
112864241  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
112869018  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
112852350  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
112872144  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
112867501  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
112868264  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
112851861  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
112862105  CDC5L; cell division cycle 5-like protein [KO:K12860]
112871783  BCAS2; pre-mRNA-splicing factor SPF27 isoform X1 [KO:K12861]
112858364  PLRG1; LOW QUALITY PROTEIN: pleiotropic regulator 1 [KO:K12862]
112865320  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
112869511  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
112865282  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
112853784  heat shock 70 kDa protein 1-like [KO:K03283]
112853785  heat shock 70 kDa protein 1-like [KO:K03283]
112870878  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
112867381  WBP11; WW domain-binding protein 11 [KO:K12866]
112855423  SNW1; SNW domain-containing protein 1 [KO:K06063]
112852899  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
112870728  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
112871809  pre-mRNA-splicing factor SYF2-like [KO:K12868]
112869724  CRNKL1; crooked neck-like protein 1 [KO:K12869]
112859425  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
112862443  PPIL1; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
112869245  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase E-like [KO:K09564] [EC:5.2.1.8]
112852653  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
112860913  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
112860009  BUD31; protein BUD31 homolog [KO:K12873]
112855296  AQR; RNA helicase aquarius [KO:K12874]
112855142  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
112864546  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112871924  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
112871833  MAGOH; protein mago nashi homolog isoform X1 [KO:K12877]
112867874  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
112868288  THOC1; LOW QUALITY PROTEIN: THO complex subunit 1 [KO:K12878]
112870647  THOC2; THO complex subunit 2 [KO:K12879]
112861250  THOC3; THO complex subunit 3 [KO:K12880]
112866831  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
112850315  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
112870680  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
112855510  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112862171  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112868559  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112868792  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112855729  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112871194  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
112867380  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
112855360  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
112871325  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
112868607  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
112852957  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
112863128  HNRNPU; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U [KO:K12888]
112868807  PCBP1; LOW QUALITY PROTEIN: poly(rC)-binding protein 1 [KO:K12889]
112853397  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112861961  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112855932  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
112869495  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112871849  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
112870162  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
112849913  TRA2B; transformer-2 protein homolog beta [KO:K12897]
112866643  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
112848638  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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