KEGG   PATHWAY: pcoo04727
Entry
pcoo04727                   Pathway                                
Name
GABAergic synapse - Puma concolor (puma)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
pcoo04727  GABAergic synapse
pcoo04727

Other DBs
GO: 0051932
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112867263  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
112867402  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
112863546  GLS2; glutaminase liver isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
112866552  GLS; glutaminase kidney isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
112867192  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
112848567  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
112869336  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
112853237  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
112855891  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
112858021  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
112858034  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
112871326  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
112860278  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
112860281  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
112861469  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
112855888  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
112858237  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
112855309  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186]
112858174  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
112860212  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
112848543  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
112871204  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
112871113  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
112861281  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
112852313  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112871920  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112869273  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112864470  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112853117  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112850908  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112854009  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
112857163  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
112857590  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112867267  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112862199  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
112848792  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
112872197  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
112856228  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
112869469  SLC12A5; solute carrier family 12 member 5 [KO:K23967]
112862054  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
112862086  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
112850113  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
112852304  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112860864  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112867221  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
112852481  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
112871144  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
112857700  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112852537  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
112853616  GABBR1; LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
112852602  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
112872095  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112866857  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
112857493  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
112848368  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
112859921  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
112867306  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
112849315  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
112854988  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
112856354  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
112852144  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112851564  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112848743  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112852664  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112869453  GNG10; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112866879  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112848961  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112852984  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112866333  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
112854055  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112859788  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112860207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112864041  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
112855238  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112849881  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112867731  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112857348  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112859389  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
112853291  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112849482  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
112858122  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
112867625  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
112857907  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
112867710  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
112857852  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
112870888  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
pcoo00020  Citrate cycle (TCA cycle)
pcoo00250  Alanine, aspartate and glutamate metabolism
pcoo04144  Endocytosis
pcoo04721  Synaptic vesicle cycle
KO pathway
ko04727   
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