KEGG   PATHWAY: phyp00260
Entry
phyp00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pangasianodon hypophthalmus (striped catfish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
phyp00260  Glycine, serine and threonine metabolism
phyp00260

Module
phyp_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:phyp00260]
phyp_M00047  Creatine pathway [PATH:phyp00260]
phyp_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:phyp00260]
phyp_M00555  Betaine biosynthesis, choline => betaine [PATH:phyp00260]
phyp_M00621  Glycine cleavage system [PATH:phyp00260]
phyp_M00974  Betaine metabolism, animals, betaine => glycine [PATH:phyp00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pangasianodon hypophthalmus (striped catfish) [GN:phyp]
Gene
113527090  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
113532578  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
113536189  shmt1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
113536332  serine hydroxymethyltransferase, cytosolic-like isoform X1 [KO:K00600] [EC:2.1.2.1]
113528254  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113539323  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113547165  grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
113544290  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
113531234  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
113537430  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
113543109  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
113545796  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
113529410  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
113526128  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113542459  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
113543205  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
113527902  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
113545361  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
113538588  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
113545100  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
113532067  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
113537972  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
113525579  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
113544102  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
113528079  aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
113537179  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
113529982  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
113530056  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
113536419  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
113526747  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
113542437  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
113535665  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113526986  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
113531337  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
113533247  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
113543635  aldh7a1; LOW QUALITY PROTEIN: alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
113535813  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
113535384  dmgdh; LOW QUALITY PROTEIN: dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
113532529  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113544041  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
113545046  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
113546747  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
113537764  cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
113545943  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
113544275  uncharacterized protein LOC113544275 [KO:K01754] [EC:4.3.1.19]
113542475  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
113533750  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
113533371  uncharacterized protein LOC113533371 isoform X1 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
phyp00010  Glycolysis / Gluconeogenesis
phyp00020  Citrate cycle (TCA cycle)
phyp00230  Purine metabolism
phyp00250  Alanine, aspartate and glutamate metabolism
phyp00270  Cysteine and methionine metabolism
phyp00290  Valine, leucine and isoleucine biosynthesis
phyp00330  Arginine and proline metabolism
phyp00470  D-Amino acid metabolism
phyp00564  Glycerophospholipid metabolism
phyp00600  Sphingolipid metabolism
phyp00620  Pyruvate metabolism
phyp00630  Glyoxylate and dicarboxylate metabolism
phyp00640  Propanoate metabolism
phyp00860  Porphyrin metabolism
phyp00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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