KEGG   PATHWAY: pkl04145
Entry
pkl04145                    Pathway                                
Name
Phagosome - Pipistrellus kuhlii (Kuhl's pipistrelle)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pkl04145  Phagosome
pkl04145

Other DBs
GO: 0045335
Organism
Pipistrellus kuhlii (Kuhl's pipistrelle) [GN:pkl]
Gene
118731955  VAMP3; vesicle-associated membrane protein 3 isoform X1 [KO:K13505]
118724726  STX12; syntaxin-12 [KO:K13813]
118705496  STX7; syntaxin-7 isoform X1 [KO:K08488]
118705761  syntaxin-7 [KO:K08488]
118704529  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118710780  ACTB; actin, cytoplasmic 1 [KO:K05692]
118704878  CORO1A; coronin-1A [KO:K13882]
118708991  STX18; syntaxin-18 [KO:K08492]
118727144  SEC22B; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
118705707  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
118715990  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118716976  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
118718034  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118718036  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
118726079  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
118705668  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X1 [KO:K06752]
118705669  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
118705670  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
118705671  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705672  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705673  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118705674  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118705675  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118705676  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118706033  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
118706034  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118715392  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
118728265  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
118726615  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
118728546  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
118707790  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
118722785  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
118704484  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
118724554  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118717509  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
118726094  ATP6V1B2; V-type proton ATPase subunit B, brain isoform isoform X1 [KO:K02147]
118728199  LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1-like [KO:K02148]
118715949  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118718153  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
118703425  V-type proton ATPase subunit D-like [KO:K02149]
118716521  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
118728791  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118717811  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
118710782  LOW QUALITY PROTEIN: V-type proton ATPase subunit E 1-like [KO:K02150]
118712563  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
118720362  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
118716087  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118716982  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118711566  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
118714467  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
118713530  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118706850  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
118710434  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
118726660  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
118720391  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
118718533  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
118718257  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118705151  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
118702970  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
118722661  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
118706405  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
118708272  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
118721510  RAB7B; ras-related protein Rab-7b [KO:K07898]
118702586  rab-interacting lysosomal protein [KO:K13883]
118704248  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
118712802  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
118714273  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
118709647  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
118720989  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
118715439  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
118728759  TUBA1B; tubulin alpha-1B chain [KO:K07374]
118728760  TUBA1A; tubulin alpha-1A chain [KO:K07374]
118728863  tubulin alpha-1C chain [KO:K07374]
118729376  tubulin alpha-4 chain isoform X1 [KO:K07374]
118714290  tubulin alpha-1C chain-like [KO:K07374]
118731844  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118709593  tubulin alpha-1D chain-like [KO:K07374]
118725584  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
118725585  tubulin alpha-3 chain-like [KO:K07374]
118702746  tubulin alpha-1C chain-like [KO:K07374]
118714072  TUBB; tubulin beta chain [KO:K07375]
118707037  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
118731426  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
118707326  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
118723429  tubulin beta-2B chain [KO:K07375]
118724463  tubulin beta-2B chain isoform X1 [KO:K07375]
118708731  TUBB1; tubulin beta-1 chain [KO:K07375]
118710118  tubulin beta-3 chain [KO:K07375]
118729823  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
118721987  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
118709988  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
118729847  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
118725282  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
118728102  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
118706133  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118732211  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
118732242  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118716426  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118708937  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118727473  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
118707569  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
118727233  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
118716263  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
118727839  SEC61G; LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma [KO:K07342]
118705649  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118705652  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
118710375  CALR; calreticulin [KO:K08057]
118725933  CANX; calnexin isoform X1 [KO:K08054]
118721121  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
118716879  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
118716880  LOW QUALITY PROTEIN: low affinity immunoglobulin gamma Fc region receptor III-B-like [KO:K06463]
118730584  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
118731522  integrin alpha-M-like [KO:K06461]
118723220  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
118731250  complement C3-like [KO:K03990]
118731258  C3; complement C3 [KO:K03990]
118714846  COLEC11; collectin-11 [KO:K10066]
118707726  COLEC12; collectin-12 [KO:K10062]
118718953  mannose-binding protein C-like [KO:K03991]
118718957  mannose-binding protein C-like [KO:K03991]
118719079  mannose-binding protein A-like isoform X1 [KO:K03991]
118719141  pulmonary surfactant-associated protein A-like isoform X1 [KO:K10067]
118719077  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
118719078  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
118718755  ITGAV; integrin alpha-V [KO:K06487]
118702990  ITGA2; integrin alpha-2 [KO:K06481]
118729395  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118727948  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118726386  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118722815  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118723784  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
118703435  THBS4; thrombospondin-4 [KO:K04659]
118712101  THBS2; thrombospondin-2 [KO:K04659]
118721623  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
118725822  cartilage oligomeric matrix protein [KO:K04659]
118711134  TLR2; toll-like receptor 2 [KO:K10159]
118707781  TLR6; toll-like receptor 6 [KO:K10169]
118716098  TLR4; toll-like receptor 4 [KO:K10160]
118711536  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
118730957  MRC1; macrophage mannose receptor 1 [KO:K06560]
118709419  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
118726234  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
118726017  CD209 antigen-like protein C isoform X1 [KO:K06563]
118729090  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
118730079  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
118709841  MARCO; macrophage receptor MARCO [KO:K13884]
118729088  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
118710479  SCARB1; scavenger receptor class B member 1 [KO:K13885]
118714362  CD36; platelet glycoprotein 4 [KO:K06259]
118720692  cytochrome b-245 light chain [KO:K08009]
118702370  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118710908  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118702833  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
118721554  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
118730522  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
pkl04142  Lysosome
pkl04144  Endocytosis
pkl04610  Complement and coagulation cascades
pkl04612  Antigen processing and presentation
pkl04620  Toll-like receptor signaling pathway
pkl04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
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