KEGG   PATHWAY: plai04141
Entry
plai04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Poecilia latipinna (sailfin molly)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
plai04141  Protein processing in endoplasmic reticulum
plai04141

Other DBs
GO: 0030433 0034976
Organism
Poecilia latipinna (sailfin molly) [GN:plai]
Gene
106958414  protein transport protein Sec61 subunit alpha-like isoform X1 [KO:K10956]
106958417  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
106953257  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
106945987  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
106950782  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
106947164  sec62; translocation protein SEC62 [KO:K12275]
106940628  translocation protein SEC63 homolog [KO:K09540]
106953246  rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
106934427  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
106938528  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
106962977  dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
106961944  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit isoform X1 [KO:K12670]
106957508  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
106951578  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
106954228  stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
106936854  magnesium transporter protein 1 isoform X1 [KO:K19478]
106951992  tumor suppressor candidate 3-like [KO:K19478]
106942657  tumor suppressor candidate 3 [KO:K19478]
106946571  ostc; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
106955827  tmem258; transmembrane protein 258 [KO:K26502]
106949614  mogs; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
106949785  ckap4; cytoskeleton-associated protein 4 [KO:K13999]
106959260  rrbp1; ribosome-binding protein 1 isoform X1 [KO:K14000]
106938199  LOW QUALITY PROTEIN: nucleotide exchange factor SIL1-like [KO:K14001]
106938780  LOW QUALITY PROTEIN: nucleotide exchange factor SIL1-like [KO:K14001]
106939523  hyou1; hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
106954595  hspa5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
106950575  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
106937087  dnajc1; dnaJ homolog subfamily C member 1 [KO:K09521]
106955026  dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
106954569  dnaJ homolog subfamily C member 3-like [KO:K09523]
106946411  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
106947971  hsp90b1; endoplasmin [KO:K09487]
106956492  ganab; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
106949759  glucosidase 2 subunit beta-like isoform X1 [KO:K08288]
106958376  prkcsh; glucosidase 2 subunit beta [KO:K08288]
106936340  canx; calnexin isoform X1 [KO:K08054]
106951845  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
106961167  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
106936274  calreticulin-like [KO:K08057]
106951082  calreticulin-like [KO:K08057]
106944621  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
106959810  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
106954241  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
106936359  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
106951546  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
106949924  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
106952433  lman1; protein ERGIC-53 [KO:K10080]
106937127  preb; prolactin regulatory element-binding protein [KO:K14003]
106940938  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
106944655  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
106953899  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
106952147  sec13; protein SEC13 homolog [KO:K14004]
106940883  protein transport protein Sec31A-like isoform X1 [KO:K14005]
106963269  sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
106937386  protein transport protein Sec23A [KO:K14006]
106959775  protein transport protein Sec23A [KO:K14006]
106940935  protein transport protein Sec24A-like isoform X1 [KO:K14007]
106949485  protein transport protein Sec24B-like isoform X1 [KO:K14007]
106955965  protein transport protein Sec24C-like isoform X1 [KO:K14007]
106935650  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
106960787  sec24d; protein transport protein Sec24D isoform X1 [KO:K14007]
106955006  uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
106957499  uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
106949451  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1 [KO:K10084]
106943133  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
106948181  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
106961222  edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
106952161  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
106948840  pdia4; protein disulfide-isomerase A4 isoform X1 [KO:K09582] [EC:5.3.4.1]
106953734  pdia6; protein disulfide-isomerase A6 isoform X1 [KO:K09584] [EC:5.3.4.1]
106937403  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
106953213  ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
106962705  ero1b; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
106953325  os9; protein OS-9 isoform X1 [KO:K10088]
106951878  erlec1; endoplasmic reticulum lectin 1 [KO:K14008]
106934485  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
106934490  translocon-associated protein subunit alpha-like [KO:K13249]
106962801  ssr2; translocon-associated protein subunit beta [KO:K13250]
106934429  ssr3; translocon-associated protein subunit gamma [KO:K13251]
106935735  ssr4; translocon-associated protein subunit delta [KO:K04571]
106943373  bcap31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
106961315  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
106937677  tram1; translocating chain-associated membrane protein 1 [KO:K14010]
106953056  derl1; derlin-1 [KO:K11519]
106955941  derlin-2-like isoform X1 [KO:K13989]
106956196  derl2; derlin-2 [KO:K13989]
106961679  ubxn1; UBX domain-containing protein 1 [KO:K24348]
106949494  ubxn4; UBX domain-containing protein 4 [KO:K24348]
106940764  ubxn2a; UBX domain-containing protein 2A [KO:K24349]
106949682  ubxn6; UBX domain-containing protein 6 isoform X1 [KO:K14011]
106963392  nsfl1c; NSFL1 cofactor p47 isoform X1 [KO:K14012]
106947737  svip; small VCP/p97-interacting protein [KO:K14014]
106944587  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
106945994  transitional endoplasmic reticulum ATPase-like isoform X1 [KO:K13525]
106960896  nploc4; nuclear protein localization protein 4 homolog [KO:K14015]
106956801  ufd1l; ubiquitin fusion degradation protein 1 homolog [KO:K14016]
106961650  heat shock 70 kDa protein 1 [KO:K03283]
106945881  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
106946543  heat shock 70 kDa protein-like [KO:K03283]
106948160  heat shock cognate 71 kDa protein-like [KO:K03283]
106964361  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
106943044  dnaJ homolog subfamily A member 1-like [KO:K09502]
106943048  dnaJ homolog subfamily A member 1-like [KO:K09502]
106961613  dnaJ homolog subfamily A member 2 [KO:K09503]
106954919  dnaJ homolog subfamily A member 2-like [KO:K09503]
106963587  dnaJ homolog subfamily B member 1-like [KO:K09507]
106945991  dnajb1; dnaJ homolog subfamily B member 1 [KO:K09507]
106962467  dnajb2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
106940885  dnaJ homolog subfamily B member 12-like [KO:K09518]
106961116  dnaJ homolog subfamily B member 12-like [KO:K09518]
106949233  dnajc5g; dnaJ homolog subfamily C member 5G isoform X1 [KO:K09525]
106941976  dnaJ homolog subfamily C member 5-like [KO:K09525]
106935860  dnaJ homolog subfamily C member 5-like [KO:K09525]
106937392  dnaJ homolog subfamily C member 5-like [KO:K09525]
106952637  dnaJ homolog subfamily C member 5-like [KO:K09525]
106965042  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
106955541  heat shock protein HSP 90-alpha [KO:K04079]
106955542  heat shock protein HSP 90-alpha 1 [KO:K04079]
106942468  heat shock protein HSP 90-beta [KO:K04079]
106956961  hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
106964952  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
106964898  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
106951622  hspbp1; hsp70-binding protein 1 [KO:K09562]
106939151  alpha-crystallin A chain [KO:K09541]
106956144  alpha-crystallin B chain-like [KO:K09542]
106945879  hspb6; heat shock protein beta-6 [KO:K09542]
106936332  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
106940083  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
106945064  plaa; phospholipase A-2-activating protein isoform X1 [KO:K14018]
106944540  rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
106948451  rad23a; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
106954533  ubqln4; ubiquilin-4 isoform X1 [KO:K04523]
106960738  ubqln1; ubiquilin-1 [KO:K04523]
106960865  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
106951700  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
106963825  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
106963566  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
106957937  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106954409  nfe2l2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
106936789  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106964606  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106956596  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
106949142  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
106963917  atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
106958253  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
106942071  wfs1; wolframin [KO:K14020]
106954672  wolframin-like isoform X1 [KO:K14020]
106961953  mbtps1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
106957979  mbtps2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
106939483  xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
106957131  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106946130  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106956159  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
106950855  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106947210  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106953170  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106954894  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
106950657  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106962379  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106944787  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106959048  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106954976  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106962490  apoptosis regulator BAX-like [KO:K02159]
106953891  apoptosis regulator BAX-like [KO:K02159]
106960487  apoptosis regulator BAX-like [KO:K02159]
106935684  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
106943754  calpain-8-like [KO:K01367] [EC:3.4.22.52]
106937324  calpain-A-like [KO:K01367] [EC:3.4.22.52]
106959256  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
106961192  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
106959257  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
106959267  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
106961194  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
106945839  march6; E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
106939098  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
106955132  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
106949181  ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
106957690  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
106954024  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
106957953  syvn1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
106958852  rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
106961365  rnf185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
106960774  vimp; selenoprotein S [KO:K14025]
106960692  sel1l; protein sel-1 homolog 1 [KO:K14026]
106963411  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
106945602  amfr; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
106942924  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
106947562  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
106934511  ube2d1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
106962957  ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
106952053  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
106952398  ube2d2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
106958573  ube2d3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
106936929  park2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
106961597  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
106961041  cul1; cullin-1 isoform X1 [KO:K03347]
106935269  skp1; S-phase kinase-associated protein 1 [KO:K03094]
106955166  F-box only protein 2-like [KO:K10099]
106954116  F-box only protein 6-like [KO:K10100]
106954140  F-box only protein 6-like isoform X1 [KO:K10100]
106954164  F-box only protein 6-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
plai00510  N-Glycan biosynthesis
plai03050  Proteasome
plai03060  Protein export
plai04210  Apoptosis
KO pathway
ko04141   
LinkDB

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