KEGG   PATHWAY: pmoo03013
Entry
pmoo03013                   Pathway                                
Name
Nucleocytoplasmic transport - Penaeus monodon (black tiger shrimp)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pmoo03013  Nucleocytoplasmic transport
pmoo03013

Other DBs
GO: 0050658
Organism
Penaeus monodon (black tiger shrimp) [GN:pmoo]
Gene
119579976  aladin-like [KO:K14320]
119573114  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119596480  LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119573017  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
119574557  nuclear pore complex protein Nup88-like [KO:K14318]
119597641  LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2-like [KO:K12172] [EC:2.3.2.-]
119593007  ran GTPase-activating protein 1-like [KO:K14319]
119589096  SUMO-conjugating enzyme UBC9-B [KO:K10577]
119582609  small ubiquitin-related modifier-like [KO:K12160]
119585856  small ubiquitin-related modifier 3-like [KO:K12160]
119590828  nuclear pore complex protein Nup85-like [KO:K14304]
119594378  protein SEC13 homolog [KO:K14004]
119576761  LOW QUALITY PROTEIN: nuclear pore complex protein Nup107-like [KO:K14301]
119583244  nuclear pore complex protein Nup133-like [KO:K14300]
119593960  LOW QUALITY PROTEIN: nucleoporin SEH1-like [KO:K14299]
119599514  nucleoporin SEH1-like isoform X1 [KO:K14299]
119583053  nucleoporin Nup43-like [KO:K14305]
119587924  nucleoporin Nup37-like [KO:K14302]
119584335  LOW QUALITY PROTEIN: protein ELYS-like [KO:K25129]
119577910  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
119574953  nucleoporin p54-like [KO:K14308]
119589933  LOW QUALITY PROTEIN: nuclear pore complex protein Nup205-like [KO:K14310]
119591430  nucleoporin NUP188 homolog [KO:K14311]
119582792  LOW QUALITY PROTEIN: nuclear pore complex protein Nup155-like [KO:K14312]
119575659  LOW QUALITY PROTEIN: nuclear pore complex protein Nup93-like [KO:K14309]
119577122  nucleoporin NDC1-like [KO:K14315]
119582493  Krueppel homolog 2-like [KO:K20724]
119577916  importin subunit alpha-1-like [KO:K15043]
119583823  importin subunit alpha-3-like isoform X1 [KO:K23583]
119589996  importin subunit alpha-7-like [KO:K15042]
119585100  importin subunit beta-1-like [KO:K14293]
119596787  transportin-1-like [KO:K18752]
119596611  transportin-3-like isoform X1 [KO:K15436]
119574299  importin-4-like [KO:K20221]
119577196  importin-5-like [KO:K20222]
119598740  importin-7-like isoform X1 [KO:K20223]
119578745  importin-9-like isoform X1 [KO:K20224]
119599376  LOW QUALITY PROTEIN: importin-13-like [KO:K25202]
119584294  snurportin-1-like [KO:K13151]
119590619  exportin-1-like [KO:K14290]
119585683  exportin-2-like [KO:K18423]
119585939  LOW QUALITY PROTEIN: exportin-2-like [KO:K18423]
119594003  exportin-T-like [KO:K14288]
119581783  exportin-4-like [KO:K25203]
119574176  exportin-5-like [KO:K14289]
119587703  exportin-6-A-like [KO:K25204]
119587000  exportin-7-like [KO:K18460]
119594084  GTP-binding nuclear protein Ran [KO:K07936]
119595505  LOW QUALITY PROTEIN: elongation factor 1-alpha-like [KO:K03231]
119596705  LOW QUALITY PROTEIN: elongation factor 1-alpha-like [KO:K03231]
119580062  phosphorylated adapter RNA export protein-like [KO:K14291]
119596974  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
119592144  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
119599441  60S ribosomal export protein NMD3-like [KO:K07562]
119585278  RNA-binding protein 8A-like [KO:K12876]
119585279  RNA-binding protein 8A-like [KO:K12876]
119585425  RNA-binding protein 8A-like [KO:K12876]
119598126  protein mago nashi homolog isoform X1 [KO:K12877]
119592630  LOW QUALITY PROTEIN: eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
119577136  histone deacetylase complex subunit SAP18-like [KO:K14324]
119585661  LOW QUALITY PROTEIN: RNA-binding protein with serine-rich domain 1-B-like [KO:K14325]
119574215  pinin-like [KO:K13114]
119597369  THO complex subunit 4-like [KO:K12881]
119587201  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119593291  regulator of nonsense transcripts 2-like [KO:K14327]
119596467  regulator of nonsense transcripts 3B-like [KO:K14328]
119599374  regulator of nonsense transcripts 3B-like [KO:K14328]
119594010  nuclear RNA export factor 1-like [KO:K14284]
119585209  nuclear RNA export factor 1-like [KO:K14284]
119596906  NTF2-related export protein-like isoform X1 [KO:K14285]
119588511  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
119582927  serine/arginine repetitive matrix protein 1-like [KO:K13171]
119575369  THO complex subunit 1-like isoform X1 [KO:K12878]
119572400  THO complex subunit 2-like [KO:K12879]
119585427  LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
119594097  THO complex subunit 6 homolog [KO:K13175]
119584986  THO complex subunit 7 homolog [KO:K13176]
119584985  THO complex subunit 7 homolog [KO:K13176]
119580824  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pmoo03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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