KEGG   PATHWAY: pon04814
Entry
pon04814                    Pathway                                
Name
Motor proteins - Pongo abelii (Sumatran orangutan)
Class
Cellular Processes; Cell motility
Pathway map
pon04814  Motor proteins
pon04814

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100453874  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100174119  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform 1 [KO:K10415]
100434776  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
100171820  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100449237  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100445780  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
100447854  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100437967  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
100447142  DYNLRB2; dynein light chain roadblock-type 2 isoform X2 [KO:K10419]
100443115  DYNLRB1; dynein light chain roadblock-type 1 isoform X5 [KO:K10419]
100174155  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
100455644  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
100447779  dynein light chain Tctex-type 1-like isoform X1 [KO:K10420]
100434012  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
100462047  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
100461187  TCTEX1D1; tctex1 domain-containing protein 1 isoform X1 [KO:K25421]
100440409  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
100448981  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
100431601  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
100452906  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
100457061  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
100440637  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
100456482  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
100437879  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
100439511  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
100455325  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
100438935  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
100449823  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
100440290  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100456621  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
100462432  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
100447010  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
100462297  WDR78; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
100460454  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100446636  DNAL1; dynein light chain 1, axonemal [KO:K10411]
100454413  DNAL4; dynein light chain 4, axonemal [KO:K10412]
100171591  DCTN2; dynactin subunit 2 [KO:K10424]
100432041  DCTN3; dynactin subunit 3 [KO:K10425]
100173240  DCTN4; dynactin subunit 4 [KO:K10426]
100173847  DCTN5; dynactin subunit 5 [KO:K10427]
100174616  DCTN6; dynactin subunit 6 [KO:K10428]
100437673  ACTR1A; alpha-centractin [KO:K16575]
100450422  ACTR1B; beta-centractin isoform X1 [KO:K16575]
112132098  alpha-centractin-like [KO:K16575]
100434588  ACTR10; actin-related protein 10 [KO:K16576]
100442447  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100173940  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100174121  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100174717  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
100443785  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
100431701  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
100446595  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
100436042  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100445003  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100445613  TUBA1A; tubulin alpha-1A chain isoform X2 [KO:K07374]
100446260  tubulin alpha-1C chain [KO:K07374]
100444582  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100449357  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
100439869  tubulin alpha-3 chain [KO:K07374]
100434822  tubulin alpha-3 chain [KO:K07374]
112129091  tubulin alpha-3 chain [KO:K07374]
100439587  TUBA3E; tubulin alpha-3E chain [KO:K07374]
100172938  TUBB; tubulin beta chain [KO:K07375]
100448146  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
100443487  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100434432  LOW QUALITY PROTEIN: tubulin beta-8 chain [KO:K07375]
100443594  TUBB4A; tubulin beta-4A chain [KO:K07375]
100450699  TUBB2A; tubulin beta-2A chain [KO:K07375]
100452448  LOW QUALITY PROTEIN: tubulin beta-2B chain [KO:K07375]
100441382  uncharacterized protein LOC100441382 [KO:K07375]
100438882  TUBB4B; tubulin beta-4B chain [KO:K07375]
100452886  tubulin beta-8 chain-like isoform X7 [KO:K07375]
100452363  TUBB8; LOW QUALITY PROTEIN: tubulin beta-8 chain [KO:K07375]
100172516  TUBG1; tubulin gamma-1 chain [KO:K10389]
100451791  TUBG2; tubulin gamma-2 chain isoform X8 [KO:K10389]
100432031  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
100441173  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
100439671  KIF5C; kinesin heavy chain [KO:K10396]
100172845  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
100171659  KIF5B; kinesin-1 heavy chain [KO:K10396]
100172933  KLC4; kinesin light chain 4 [KO:K10407]
100173098  KLC3; kinesin light chain 3 [KO:K10407]
100173833  KLC1; kinesin light chain 1 [KO:K10407]
100172427  KLC2; kinesin light chain 2 [KO:K10407]
100173987  KIF3A; kinesin-like protein KIF3A [KO:K10394]
100456688  KIF3B; kinesin-like protein KIF3B [KO:K20196]
100189791  KIFAP3; kinesin-associated protein 3 [KO:K25388]
100169734  KIF3C; kinesin-like protein KIF3C [KO:K20197]
100443080  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
100171679  KIF1C; kinesin-like protein KIF1C [KO:K10392]
100461195  KIF1B; kinesin-like protein KIF1B isoform X2 [KO:K10392]
100450924  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
100173286  KIF13B; kinesin-like protein KIF13B [KO:K17914]
100443258  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
100439272  KIF14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
100444574  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
100451656  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
100449140  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
100450464  KIF4B; chromosome-associated kinesin KIF4B [KO:K10395]
100440029  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
100435071  KIF21B; kinesin-like protein KIF21B [KO:K24185]
100174470  KIF21A; kinesin-like protein KIF21A isoform X2 [KO:K24185]
100440114  KIF27; kinesin-like protein KIF27 [KO:K24186]
100433678  KIF11; kinesin-like protein KIF11 [KO:K10398]
100458286  KIF20A; kinesin-like protein KIF20A [KO:K10402]
100457851  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
100460820  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
100435377  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
100446373  KIF18A; kinesin-like protein KIF18A [KO:K10401]
100449464  KIF18B; kinesin-like protein KIF18B isoform X2 [KO:K26156]
100460951  KIF19; kinesin-like protein KIF19 [KO:K26157]
112131295  kinesin-like protein KIF19 [KO:K26157]
100436356  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
100189644  KIF22; kinesin-like protein KIF22 [KO:K10403]
100435810  KIF26A; kinesin-like protein KIF26A [KO:K10404]
100440014  KIF26B; kinesin-like protein KIF26B [KO:K10404]
100447463  KIF12; kinesin-like protein KIF12 [KO:K10399]
100451172  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
100174485  KIF2A; kinesin-like protein KIF2A [KO:K10393]
100458803  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
100446908  KIF2B; kinesin-like protein KIF2B [KO:K10393]
100461300  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
100459019  KIFC1; kinesin-like protein KIFC1 isoform X3 [KO:K10405]
100173743  KIFC3; kinesin-like protein KIFC3 [KO:K10406]
100455781  KIFC2; kinesin-like protein KIFC2 [KO:K10406]
100460749  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
100452038  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
100436720  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
100453444  MYO1G; unconventional myosin-Ig isoform X1 [KO:K10356]
100433686  MYO1A; unconventional myosin-Ia isoform X1 [KO:K10356]
100451129  MYO1H; unconventional myosin-Ih [KO:K10356]
100172378  MYO1D; unconventional myosin-Id [KO:K10356]
100439652  MYO1E; unconventional myosin-Ie [KO:K10356]
100444326  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
100439249  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
100432201  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
100446765  MYO5C; unconventional myosin-Vc [KO:K10357]
100434994  MYO5B; unconventional myosin-Vb [KO:K10357]
103892519  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
100432750  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
100458307  MYO7A; unconventional myosin-VIIa isoform X1 [KO:K10359]
100448506  MYO7B; unconventional myosin-VIIb [KO:K21868]
100451924  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
100435076  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
100432603  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
100450797  MYO15B; myosin XVB [KO:K10361]
100441879  MYO15A; unconventional myosin-XV isoform X1 [KO:K10361]
100441232  MYO16; unconventional myosin-XVI isoform X1 [KO:K17481]
100455030  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
100454264  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
100446660  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
100461430  MYH1; myosin-1 [KO:K24220]
100432085  MYH4; myosin-4 [KO:K24220]
100462425  myosin-8 isoform X1 [KO:K24220]
100462059  MYH2; myosin-2 [KO:K24220]
100432466  MYH3; myosin-3 [KO:K24220]
100449485  MYH7B; myosin-7B [KO:K24220]
100446668  MYH15; myosin-15 [KO:K24220]
100431713  MYH13; myosin-13 [KO:K24220]
100448828  myosin-7 [KO:K17751]
100448481  MYH6; myosin-6 [KO:K17751]
100172761  MYH10; myosin-10 isoform X3 [KO:K10352]
100450821  MYH9; myosin-9 [KO:K10352]
100454406  MYH14; myosin-14 isoform X1 [KO:K10352]
100440525  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
100174572  MYL3; myosin light chain 3 [KO:K12749]
100444983  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
100173171  MYL6; myosin light polypeptide 6 [KO:K12751]
100936351  MYL6B; myosin light chain 6B [KO:K12751]
100452166  myosin light polypeptide 6-like [KO:K12751]
100462280  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100455740  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
112134321  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
100172462  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100442785  MYL10; myosin regulatory light chain 10 [KO:K12756]
100450310  myosin regulatory light chain 12B [KO:K12757]
100172271  MYL12A; myosin regulatory light chain 12A [KO:K12757]
100432987  myosin regulatory light chain 12B isoform X1 [KO:K12757]
100449813  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100172818  ACTA1; actin, alpha skeletal muscle [KO:K10354]
100173819  ACTA2; actin, aortic smooth muscle [KO:K12313]
100442237  actin, alpha cardiac muscle 1 [KO:K12314]
100434347  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
100441387  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100173832  ACTB; actin, cytoplasmic 1 [KO:K05692]
100461583  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100432511  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
100444696  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
100458757  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
100450388  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
100451754  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
100173211  TNNI3; troponin I, cardiac muscle [KO:K12044]
100460438  TNNT2; troponin T, cardiac muscle isoform X2 [KO:K12045]
100172445  TPM1; tropomyosin alpha-1 chain [KO:K10373]
100442068  TPM2; tropomyosin beta chain isoform X3 [KO:K10374]
100174017  TPM3; tropomyosin alpha-3 chain [KO:K09290]
100439681  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

DBGET integrated database retrieval system