KEGG   PATHWAY: pprm04310
Entry
pprm04310                   Pathway                                
Name
Wnt signaling pathway - Pimephales promelas (fathead minnow)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
pprm04310  Wnt signaling pathway
pprm04310

Other DBs
GO: 0016055
Organism
Pimephales promelas (fathead minnow) [GN:pprm]
Gene
120483061  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
120469045  porcnl; porcupine O-acyltransferase like isoform X1 [KO:K00181] [EC:2.3.1.250]
120463643  wnt1; protein Wnt-1 [KO:K03209]
120484036  wnt2bb; wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
120493943  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
120487629  wnt2; protein Wnt-2 [KO:K00182]
120484207  wnt3a; protein Wnt-3a [KO:K00312]
120471546  wnt3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
120484742  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
120480813  wnt4; protein Wnt-4a isoform X1 [KO:K00408]
120481302  wnt5a; protein Wnt-5a [KO:K00444]
120476625  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
120466700  wnt6b; protein Wnt-6 [KO:K00445]
120491709  wnt6a; protein Wnt-6 isoform X1 [KO:K00445]
120476994  wnt7ba; protein Wnt-7b [KO:K00572]
120491826  protein Wnt-7a [KO:K00572]
120460451  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
120480792  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
120474366  wnt8a; protein Wnt-8a ORF1 [KO:K00714]
120474368  protein Wnt-8a ORF2 [KO:K00714]
120479342  wnt8b; protein Wnt-8b isoform X1 [KO:K00714]
120489400  wnt9b; protein Wnt-9b [KO:K01064]
120484208  wnt9a; protein Wnt-9a [KO:K01064]
120466703  wnt10a; protein Wnt-10a [KO:K01357]
120463641  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
120483248  wnt11; protein Wnt-11 [KO:K01384]
120461814  wnt11f2; protein Wnt-11 [KO:K01384]
120476775  wnt16; protein Wnt-16 [KO:K01558]
120489532  DAN domain family member 5-like [KO:K01645]
120459224  dand5; DAN domain family member 5 [KO:K01645]
120476196  notum1a; palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
120491707  notum2; carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
120480433  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b [KO:K19882] [EC:3.1.1.98]
120476906  wif1; wnt inhibitory factor 1 isoform X1 [KO:K01691]
120474541  sost; sclerostin [KO:K16834]
120474833  dkk1b; dickkopf-related protein 1b isoform X1 [KO:K02165]
120474907  dickkopf-related protein 4-like [KO:K02165]
120491102  dkk2; dickkopf-related protein 2 [KO:K02165]
120462153  dkk1a; dickkopf WNT signaling pathway inhibitor 1a [KO:K02165]
120494558  serpinf1; pigment epithelium-derived factor [KO:K19614]
120482401  sfrp1b; secreted frizzled-related protein 1b [KO:K02166]
120470237  sfrp1a; secreted frizzled-related protein 1a [KO:K02166]
120478251  sfrp2l; secreted frizzled-related protein 2-like isoform X1 [KO:K02176]
120494705  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
120487359  frzb; secreted frizzled-related protein 3 [KO:K25481]
120468618  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
120484797  rspo1; R-spondin-1 [KO:K19471]
120462252  rspo2; R-spondin-2 isoform X1 [KO:K23097]
120462328  rspo3; R-spondin-3 [KO:K23098]
120476010  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
120491878  leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
120471694  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
120470302  znrf3; E3 ubiquitin-protein ligase znrf3 isoform X1 [KO:K16273] [EC:2.3.2.27]
120491593  fzd7b; frizzled-7b [KO:K02432]
120471176  fzd1; frizzled-1 [KO:K02432]
120487057  fzd7a; frizzled-7a [KO:K02432]
120489225  fzd2; frizzled-2 [KO:K02235]
120485985  fzd3b; LOW QUALITY PROTEIN: frizzled-3b [KO:K02329]
120493566  fzd3a; frizzled-3a isoform X1 [KO:K02329]
120470831  fzd4; frizzled-4 [KO:K02354]
120482221  frizzled-8-like [KO:K02375]
120482222  frizzled-8-like [KO:K02375]
120475808  fzd8a; frizzled-8a [KO:K02375]
120486320  fzd5; frizzled-5 [KO:K02375]
120487907  frizzled-6-like [KO:K02376]
120487908  LOW QUALITY PROTEIN: frizzled-6-like [KO:K02376]
120459880  fzd9b; frizzled-9b [KO:K02842]
120485582  fzd10; frizzled-10 [KO:K02842]
120472252  fzd9a; frizzled-9 [KO:K02842]
120468208  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
120470899  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
120461328  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
120471581  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
120467828  protein APCDD1-like [KO:K25812]
120493315  apcdd1l; protein APCDD1-like [KO:K25812]
120471319  protein APCDD1-like isoform X1 [KO:K25812]
120488824  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
120476244  ccdc88c; protein Daple isoform X1 [KO:K25811]
120482843  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
120459909  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
120470251  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
120495188  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
120480699  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
120463562  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120462321  glycogen synthase kinase binding protein [KO:K03096]
120483424  zgc:86598; STKc_CK2_alpha domain-containing protein [KO:K03097] [EC:2.7.11.1]
120483425  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120484737  csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120460368  csnk2a2b; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
120492709  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
120473398  csnk2a4; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120485350  csnk2b; casein kinase II subunit beta [KO:K03115]
120468708  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
120471089  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
120471090  protein naked cuticle homolog 2-like [KO:K03213]
120484105  CXXC-type zinc finger protein 4 [KO:K03344]
120494968  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
120491526  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
120490965  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
120487004  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120465202  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
120483600  catenin beta-1-like [KO:K02105]
120489386  axin1; axin-1 isoform X1 [KO:K02157]
120460796  axin2; axin-2 [KO:K04385]
120464195  apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
120479106  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
120466341  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
120473621  tcf7; transcription factor 7 isoform X1 [KO:K02620]
120474207  tcf7l1a; transcription factor 7-like 1-A [KO:K04490]
120481307  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
120474612  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120491182  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
120479470  lzts2a; leucine zipper putative tumor suppressor 2a [KO:K26471]
120462636  lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
120463595  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
120488692  cby1; protein chibby homolog 1 [KO:K23402]
120465057  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
120471632  mcc; colorectal mutant cancer protein [KO:K26734]
120483232  ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
120460788  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
120480127  sox17; transcription factor SOX-17 [KO:K04495]
120481577  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
120460716  C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
120485956  ctbp2a; C-terminal-binding protein 2a isoform X1 [KO:K04496] [EC:1.1.1.428]
120462565  ctbp2l; C-terminal binding protein 2, like isoform X1 [KO:K04496] [EC:1.1.1.428]
120464186  tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
120487670  tle3a; transducin-like enhancer protein 3-A isoform X1 [KO:K04497]
120495357  tle2b; LOW QUALITY PROTEIN: transducin-like enhancer protein 4 [KO:K04497]
120495359  tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497]
120482730  ctnnd2b; catenin delta-2b isoform X1 [KO:K23491]
120476099  ctnnd2a; catenin delta-2 isoform X1 [KO:K23491]
120464026  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120489504  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
120462301  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120495222  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
120491698  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
120489318  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
120484418  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
120485002  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
120478430  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
120491009  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
120460054  mothers against decapentaplegic homolog 3-like [KO:K23605]
120487810  smad3b; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 3b [KO:K23605]
120493637  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120473200  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120489136  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
120481646  mycb; transcriptional regulator Myc-B [KO:K04377]
120476017  myca; transcriptional regulator Myc-A [KO:K04377]
120493498  jun; transcription factor AP-1 [KO:K04448]
120471668  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
120474998  fosl1a; fos-related antigen 1a isoform X1 [KO:K04502]
120492676  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
120476639  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
120459029  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
120490241  ccndx; cyclin Dx [KO:K10151]
120486302  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
120484740  ccn4b; cellular communication network factor 4b isoform X1 [KO:K22471]
120485433  ccn4a; cellular communication network factor 4a [KO:K22471]
120469177  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
120486255  peroxisome proliferator-activated receptor delta-like [KO:K04504]
120486256  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
120462472  psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
120464256  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
120491168  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120460052  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120461561  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
120469826  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120477867  cellular tumor antigen p53-like [KO:K04451]
120493279  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
120465104  calcyclin-binding protein [KO:K04507]
120473620  skp1; S-phase kinase-associated protein 1 [KO:K03094]
120475970  tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508]
120478207  tbl1x; F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
120471439  tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508]
120481604  fbxw11b; F-box/WD repeat-containing protein 11b isoform X1 [KO:K03362]
120473272  fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362]
120482573  cul1a; cullin-1a [KO:K03347]
120475952  cul1b; LOW QUALITY PROTEIN: cullin-1b [KO:K03347]
120462132  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
120475015  glypican-4-like [KO:K08110]
120493170  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
120481615  ror2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
120493098  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
120461217  vangl2; vang-like protein 2 [KO:K04510]
120463772  vangl1; vang-like protein 1 isoform X1 [KO:K04510]
120481403  prickle2a; prickle-like protein 2 isoform X1 [KO:K04511]
120491261  prickle3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511]
120476881  prickle1b; prickle-like protein 1b [KO:K04511]
120460428  prickle1a; prickle-like protein 1a [KO:K04511]
120480392  prickle2b; prickle-like protein 2b isoform X1 [KO:K04511]
120484328  invs; inversin [KO:K19626]
120464104  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
120493621  daam1b; disheveled-associated activator of morphogenesis 1b isoform X1 [KO:K04512]
120479771  daam1a; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
120473952  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
120473953  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
120483844  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120483860  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
120493692  rhoca; ras homolog family member Ca [KO:K04513]
120486480  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120493647  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
120479411  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
120463965  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120481534  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120490585  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120460263  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120489161  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120489651  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
120469017  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
120466717  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120479574  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120479828  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120494671  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120477635  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
120492791  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
120492792  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120487906  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120473275  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120474700  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
120482314  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120469297  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
120492648  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120480055  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120473635  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120481208  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120482117  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
120477651  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120469428  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
120460938  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120494675  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120489613  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
120492363  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
120481535  si:ch73-374l24.1; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120466805  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120462903  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
120489096  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120484709  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
120483336  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
120493931  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
120463508  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
120491001  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
120468053  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120464931  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
pprm04010  MAPK signaling pathway
pprm04110  Cell cycle
pprm04115  p53 signaling pathway
pprm04120  Ubiquitin mediated proteolysis
pprm04350  TGF-beta signaling pathway
pprm04510  Focal adhesion
pprm04520  Adherens junction
KO pathway
ko04310   
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