KEGG   PATHWAY: pruf00260
Entry
pruf00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pyrgilauda ruficollis (rufous-necked snowfinch)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pruf00260  Glycine, serine and threonine metabolism
pruf00260

Module
pruf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pruf00260]
pruf_M00047  Creatine pathway [PATH:pruf00260]
pruf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pruf00260]
pruf_M00555  Betaine biosynthesis, choline => betaine [PATH:pruf00260]
pruf_M00621  Glycine cleavage system [PATH:pruf00260]
pruf_M00974  Betaine metabolism, animals, betaine => glycine [PATH:pruf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121352777  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
121350771  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
121357466  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
121364070  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
121351313  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
121350004  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
121350017  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
121362704  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
121359786  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121351829  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
121361794  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
121361235  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
121360797  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
121365282  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
121351560  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
121364527  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
121364554  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
121351145  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
121363642  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
121352689  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
121357380  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
121348936  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
121364821  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
121365751  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121354289  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
121355110  guanidinoacetate N-methyltransferase A-like [KO:K00542] [EC:2.1.1.2]
121361133  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
121352022  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
121362563  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121355361  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
121355471  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
121361688  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
121362436  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
121353917  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
121364531  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
121364565  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
121355221  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
121357379  putative threonine dehydratase isoform X1 [KO:K01754] [EC:4.3.1.19]
121364950  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121351824  D-threo-3-hydroxyaspartate dehydratase-like isoform X1 [KO:K20498] [EC:4.3.1.18]
121361584  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pruf00010  Glycolysis / Gluconeogenesis
pruf00020  Citrate cycle (TCA cycle)
pruf00230  Purine metabolism
pruf00250  Alanine, aspartate and glutamate metabolism
pruf00270  Cysteine and methionine metabolism
pruf00290  Valine, leucine and isoleucine biosynthesis
pruf00330  Arginine and proline metabolism
pruf00470  D-Amino acid metabolism
pruf00564  Glycerophospholipid metabolism
pruf00600  Sphingolipid metabolism
pruf00620  Pyruvate metabolism
pruf00630  Glyoxylate and dicarboxylate metabolism
pruf00640  Propanoate metabolism
pruf00860  Porphyrin metabolism
pruf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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