KEGG   PATHWAY: ray04914
Entry
ray04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Rousettus aegyptiacus (Egyptian rousette)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
ray04914  Progesterone-mediated oocyte maturation
ray04914

Other DBs
GO: 0001556
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107504647  PGR; progesterone receptor isoform X1 [KO:K08556]
107521668  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
107517899  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107498704  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107520152  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107517828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107513958  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107512328  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107509910  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107515392  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
107497883  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107497895  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107500264  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
107500274  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
107516134  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107518173  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107513376  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107512406  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107502700  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107498506  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107498014  ADCY4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107518038  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
107514224  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107512248  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107497689  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107521680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107504724  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
107514004  CPEB3; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
107511045  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
107507335  CPEB2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
107505337  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
107511167  SPDYA; speedy protein A isoform X1 [KO:K08694]
107515932  speedy protein E4-like isoform X1 [KO:K08694]
107497476  SPDYC; speedy protein C [KO:K08694]
107521282  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
107501476  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
107513901  CCNA1; cyclin-A1 [KO:K06627]
107521174  CCNA2; LOW QUALITY PROTEIN: cyclin-A2 [KO:K06627]
107500741  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
107501998  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
107521381  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
107508942  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
107515836  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
107497830  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107503561  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
107519754  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
107501695  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
107500168  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
107498788  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
107498727  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
107501075  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
107514995  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
107511022  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
107516089  PLK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
107513304  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
107506543  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
107518727  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
107513269  INS; insulin isoform X1 [KO:K04526]
107501166  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107509347  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107513978  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107521783  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107498395  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107519402  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
107497434  KRAS; GTPase KRas isoform X1 [KO:K07827]
107509353  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
107504052  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107519729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107500669  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
107497366  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
107510875  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
107513121  mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
107513122  mitotic spindle assembly checkpoint protein MAD2B-like [KO:K13728]
107520110  FZR1; fizzy-related protein homolog [KO:K03364]
107509936  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
107503100  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
107508179  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
107515713  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
107515244  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
107514354  CDC16; cell division cycle protein 16 homolog [KO:K03353]
107513236  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
107518724  CDC23; cell division cycle protein 23 homolog [KO:K03355]
107520347  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
107520272  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
107500750  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
107508490  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
107517377  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
107519515  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
107515869  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
ray04010  MAPK signaling pathway
ray04110  Cell cycle
KO pathway
ko04914   
LinkDB

DBGET integrated database retrieval system