KEGG   PATHWAY: rno00350
Entry
rno00350                    Pathway                                
Name
Tyrosine metabolism - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
Pathway map
rno00350  Tyrosine metabolism
rno00350

Module
rno_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:rno00350]
rno_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:rno00350]
rno_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:rno00350]
Other DBs
GO: 0006570
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24401  Got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
306540  Got1l1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
25721  Got2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
24813  Tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
298483  Lao1; L-amino acid oxidase 1 precursor [KO:K03334] [EC:1.4.3.2]
100360621  Il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
287305  4930438A08Rikl; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
29531  Hpd; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
360719  Hgd; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
681913  Gstz1; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
29383  Fah; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
308800  Tyr; tyrosinase precursor [KO:K00505] [EC:1.14.18.1]
25085  Th; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
290484  Dct; dopachrome tautomerase precursor [KO:K01827] [EC:5.3.3.12]
298182  Tyrp1; 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor [KO:K00506] [EC:1.14.18.-]
24311  Ddc; aromatic-L-amino-acid decarboxylase isoform a [KO:K01593] [EC:4.1.1.28 4.1.1.105]
25699  Dbh; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
24661  Pnmt; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
24267  Comt; catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
308868  Lrtomt; transmembrane O-methyltransferase homolog [KO:K00545] [EC:2.1.1.6]
25750  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
29253  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
29473  Aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
25375  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
309147  Aldh3b1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
688778  Aldh3b3; aldehyde dehydrogenase family 3 member B3 isoform X1 [KO:K00129] [EC:1.2.1.5]
688800  Aldh3b2; aldehyde dehydrogenase family 3 member B2 isoform X2 [KO:K00129] [EC:1.2.1.5]
120099971  Aldh3b2l1; aldehyde dehydrogenase family 3 member B3 isoform X2 [KO:K00129] [EC:1.2.1.5]
120098481  Aldh3b2-ps1; aldehyde dehydrogenase family 3 member B2-like isoform X1 [KO:K00129] [EC:1.2.1.5]
120099972  Aldh3b3l-ps1; aldehyde dehydrogenase family 3 member B2-like isoform X1 [KO:K00129] [EC:1.2.1.5]
24172  Adh1c; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
171178  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
29646  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
100145871  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
310903  Adh6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
54314  Tpo; thyroid peroxidase precursor [KO:K00431] [EC:1.11.1.8]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
302980  Fahd1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
81683  Mif; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
287782  Mifl4; macrophage migration inhibitory factor-like [KO:K07253] [EC:5.3.2.1]
679748  Mifl2; macrophage migration inhibitory factor-like [KO:K07253] [EC:5.3.2.1]
366675  Mifl3; macrophage migration inhibitory factor-like [KO:K07253] [EC:5.3.2.1]
103692026  Mifl1; macrophage migration inhibitory factor-like [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00360  Phenylalanine metabolism
rno00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rno00620  Pyruvate metabolism
rno00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system