KEGG   PATHWAY: rno00982
Entry
rno00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Rattus norvegicus (rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rno00982  Drug metabolism - cytochrome P450
rno00982

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
84493  Fmo3; flavin-containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
25256  Fmo1; flavin-containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
246245  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
246248  Fmo5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
246247  Fmo4; dimethylaniline monooxygenase [N-oxide-forming] 4 long isoform [KO:K00485] [EC:1.14.13.8 1.8.1.-]
289193  Fmo13; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
304922  Fmo6; putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
685365  Fmo9; flavin containing monooxygenase 9 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
685351  Fmol; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
81869  Gstm7; glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
24421  Gsta1; glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
24422  Gsta2; glutathione S-transferase alpha-1 [KO:K00799] [EC:2.5.1.18]
24424  Gstm2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
25260  Gstt1; glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
29487  Gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
57298  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
295037  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
171341  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
64352  Gstm5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
289197  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
114846  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
300850  Gsta4; glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
309465  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
499689  Gstm4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
24423  Gstm1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
494499  Gsta5; glutathione S-transferase alpha-2 [KO:K00799] [EC:2.5.1.18]
494500  Gsta3; glutathione S-transferase alpha-5 isoform 1 [KO:K00799] [EC:2.5.1.18]
499688  Gstm6; glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
501110  Gsta6; glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
499422  Gstt3; glutathione S-transferase, theta 3 [KO:K00799] [EC:2.5.1.18]
686922  Gstt4; glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
295362  Gstm6l; glutathione S-transferase, mu 6-like [KO:K00799] [EC:2.5.1.18]
498340  Mgst3l1; glutathione S-transferase 3, mitochondrial-like [KO:K00799] [EC:2.5.1.18]
363205  Gsta3l1; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
24426  Gstp1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100911464  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
293656  Gstp3; Glutathione S-transferase P-like isoform 2 [KO:K23790] [EC:2.5.1.18]
297029  Gstk1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
58962  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
24172  Adh1c; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
171178  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
29646  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
100145871  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
310903  Adh6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
25375  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
309147  Aldh3b1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
688778  Aldh3b3; aldehyde dehydrogenase family 3 member B3 isoform X1 [KO:K00129] [EC:1.2.1.5]
688800  Aldh3b2; aldehyde dehydrogenase family 3 member B2 isoform X2 [KO:K00129] [EC:1.2.1.5]
120099971  Aldh3b2l1; aldehyde dehydrogenase family 3 member B3 isoform X2 [KO:K00129] [EC:1.2.1.5]
120098481  Aldh3b2-ps1; aldehyde dehydrogenase family 3 member B2-like isoform X1 [KO:K00129] [EC:1.2.1.5]
120099972  Aldh3b3l-ps1; aldehyde dehydrogenase family 3 member B2-like isoform X1 [KO:K00129] [EC:1.2.1.5]
25750  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
29253  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
83808  Ugt2b35; UDP-glucuronosyltransferase 2B15 precursor [KO:K00699] [EC:2.4.1.17]
24862  Ugt2b; UDP-glucuronosyltransferase 2B2 precursor [KO:K00699] [EC:2.4.1.17]
63867  Ugt2a1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
574523  Ugt1a5; UDP-glucuronosyltransferase 1A5 precursor [KO:K00699] [EC:2.4.1.17]
301595  Ugt1a8; UDP-glucuronosyltransferase 1A8 precursor [KO:K00699] [EC:2.4.1.17]
24861  Ugt1a1; UDP-glucuronosyltransferase 1A1 precursor [KO:K00699] [EC:2.4.1.17]
113992  Ugt1a6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
289533  Ugt2a3; UDP-glucuronosyltransferase 2A3 precursor [KO:K00699] [EC:2.4.1.17]
266685  Ugt2b15; UDP-glucuronosyltransferase 2B17 precursor [KO:K00699] [EC:2.4.1.17]
29623  Ugt2b37; UDP-glucuronosyltransferase 2B37 precursor [KO:K00699] [EC:2.4.1.17]
286954  Ugt2b1; UDP-glucuronosyltransferase 2B1 precursor [KO:K00699] [EC:2.4.1.17]
396552  Ugt1a9; UDP glycosyltransferase 1 family, polypeptide A10 precursor [KO:K00699] [EC:2.4.1.17]
396551  Ugt1a3; UDP-glucuronosyltransferase 1A3 precursor [KO:K00699] [EC:2.4.1.17]
154516  Ugt1a7c; UDP-glucuronosyltransferase 1A7 precursor [KO:K00699] [EC:2.4.1.17]
396527  Ugt1a2; UDP-glucuronosyltransferase 1-2 precursor [KO:K00699] [EC:2.4.1.17]
305264  Ugt2b10; UDP-glucuronosyltransferase 2B10 precursor [KO:K00699] [EC:2.4.1.17]
286989  Ugt2b7; UDP-glucuronosyltransferase 2B7 precursor [KO:K00699] [EC:2.4.1.17]
501907  Ugt2b34l1; UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
134478834  UDP-glucuronosyltransferase 2B2 isoform X1 [KO:K00699] [EC:2.4.1.17]
24297  Cyp1a2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
25086  Cyp2e1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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