KEGG   PATHWAY: schu00260
Entry
schu00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Siniperca chuatsi (mandarin fish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
schu00260  Glycine, serine and threonine metabolism
schu00260

Module
schu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:schu00260]
schu_M00047  Creatine pathway [PATH:schu00260]
schu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:schu00260]
schu_M00555  Betaine biosynthesis, choline => betaine [PATH:schu00260]
schu_M00621  Glycine cleavage system [PATH:schu00260]
schu_M00974  Betaine metabolism, animals, betaine => glycine [PATH:schu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122867277  tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
122882733  serine hydroxymethyltransferase, mitochondrial-like isoform X1 [KO:K00600] [EC:2.1.2.1]
122866497  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
122877548  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122886368  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122874093  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122880339  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122885074  glyctk; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
122884178  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
122865920  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
122873514  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
122874868  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122885922  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122876346  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
122878818  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
122869425  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
122862435  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
122862960  tdh; L-threonine dehydrogenase isoform X1 [KO:K15789] [EC:1.1.1.103]
122872362  L-threonine 3-dehydrogenase, mitochondrial-like isoform X1 [KO:K15789] [EC:1.1.1.103]
122883583  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
122864383  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122883785  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122865850  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
122885328  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
122869300  aoc2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
122875784  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
122882504  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
122874794  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122875522  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122879074  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
122876127  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
122865331  alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122865333  alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122875498  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122878137  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
122882706  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
122877887  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122876422  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
122876937  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
122876938  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122865754  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
122865355  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
122878853  pipox; LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
122865194  sardh; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
122861874  gnmt; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
122871764  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
122885471  cbsb; LOW QUALITY PROTEIN: cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
122878378  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
122884703  L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]
122876656  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122861692  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122886614  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
schu00010  Glycolysis / Gluconeogenesis
schu00020  Citrate cycle (TCA cycle)
schu00230  Purine metabolism
schu00250  Alanine, aspartate and glutamate metabolism
schu00270  Cysteine and methionine metabolism
schu00290  Valine, leucine and isoleucine biosynthesis
schu00330  Arginine and proline metabolism
schu00470  D-Amino acid metabolism
schu00564  Glycerophospholipid metabolism
schu00600  Sphingolipid metabolism
schu00620  Pyruvate metabolism
schu00630  Glyoxylate and dicarboxylate metabolism
schu00640  Propanoate metabolism
schu00860  Porphyrin metabolism
schu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system