KEGG PATHWAY: smeo00270

PATHWAY: smeo00270

Entry

smeo00270                   Pathway

Name

Cysteine and methionine metabolism - Silurus meridionalis (southern catfish)

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

smeo00270

Cysteine and methionine metabolism

Module

smeo_M00035

Methionine degradation [PATH:smeo00270]

smeo_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:smeo00270]

Other DBs

GO:	0006534 0006555

Organism

Silurus meridionalis (southern catfish) [GN:smeo]

Gene

124391442

cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

124379187

kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]

124379387

kyat1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]

124392173

kynurenine--oxoglutarate transaminase 3-like isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]

124383202

cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]

124378308

cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]

124397867

bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

124382658

zgc:172121; homocysteine S-methyltransferase YbgG isoform X1 [KO:K00547] [EC:2.1.1.10]

124389322

mtr; LOW QUALITY PROTEIN: methionine synthase [KO:K00548] [EC:2.1.1.13]

124398300

mat1a; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]

124398328

mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]

124393107

mat2al; methionine adenosyltransferase II, alpha-like isoform X1 [KO:K00789] [EC:2.5.1.6]

124381022

mat2ab; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]

124393902

mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]

124401433

amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

124397780

sms; spermine synthase [KO:K00802] [EC:2.5.1.22]

124399479

S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

124378844

lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

124378404

mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

124380185

methylthioribulose-1-phosphate dehydratase isoform X1 [KO:K08964] [EC:4.2.1.109]

124393656

enoph1; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]

124390498

adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

124395445

tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]

124394502

il4i1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]

124390082

gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

124376173

dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]

124401363

DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]

124389608

dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]

124399051

dnmt3bb.1; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]

124399272

uncharacterized protein LOC124399272 isoform X1 [KO:K17399] [EC:2.1.1.37]

124399982

dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 [KO:K17399] [EC:2.1.1.37]

124400191

ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]

124401037

ahcyl2b; adenosylhomocysteinase like 2b isoform X1 [KO:K01251] [EC:3.13.2.1]

124386589

ahcyl2a; adenosylhomocysteinase like 2a isoform X1 [KO:K01251] [EC:3.13.2.1]

124393117

ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

124401022

bcat1; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]

124396732

bcat2; branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]

124398429

agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

124399856

gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]

124399883

gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]

124399166

gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]

124400456

cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]

124399647

got1l1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]

124376080

got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]

124396159

got2a; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]

124381787

mpst; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

124392695

3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]

124401102

ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]

124392134

ldhbb; L-lactate dehydrogenase B-B chain [KO:K00016] [EC:1.1.1.27]

124392225

ldha; L-lactate dehydrogenase A chain isoform X1 [KO:K00016] [EC:1.1.1.27]

124389975

mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]

124377861

mdh1aa; malate dehydrogenase 1Aa, NAD (soluble) isoform X1 [KO:K00025] [EC:1.1.1.37]

124393746

mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]

124390492

sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

124381026

L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

124383361

phgdh; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

124380336

phosphoserine aminotransferase-like isoform X1 [KO:K00831] [EC:2.6.1.52]

124380778

psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors