KEGG   PATHWAY: ssc00260
Entry
ssc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Sus scrofa (pig)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ssc00260  Glycine, serine and threonine metabolism
ssc00260

Module
ssc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ssc00260]
ssc_M00047  Creatine pathway [PATH:ssc00260]
ssc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ssc00260]
ssc_M00555  Betaine biosynthesis, choline => betaine [PATH:ssc00260]
ssc_M00621  Glycine cleavage system [PATH:ssc00260]
ssc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ssc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sus scrofa (pig) [GN:ssc]
Gene
110255953  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
100626911  SHMT2; LOW QUALITY PROTEIN: serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
397181  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
100517616  AGXT; LOW QUALITY PROTEIN: serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100154014  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100522516  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
100188980  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
100154776  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
106506774  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
100144529  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100154160  PSAT1; LOW QUALITY PROTEIN: phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100316854  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
100525698  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
397065  TDH; L-threonine 3-dehydrogenase, mitochondrial precursor [KO:K15789] [EC:1.1.1.103]
100518817  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
414424  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
414909  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100520329  LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
100520513  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
110256000  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
100155425  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
396679  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
397129  DLD; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
106505596  LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial-like [KO:K02437]
110261260  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
397134  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100513890  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100126844  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
100625146  GAMT; guanidinoacetate N-methyltransferase isoform X9 [KO:K00542] [EC:2.1.1.2]
100151982  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
106504110  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
397371  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100525563  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
100515508  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110255229  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100154338  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
397444  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
110256498  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
733654  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
100155595  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100154365  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110256074  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ssc00010  Glycolysis / Gluconeogenesis
ssc00020  Citrate cycle (TCA cycle)
ssc00230  Purine metabolism
ssc00250  Alanine, aspartate and glutamate metabolism
ssc00270  Cysteine and methionine metabolism
ssc00290  Valine, leucine and isoleucine biosynthesis
ssc00330  Arginine and proline metabolism
ssc00470  D-Amino acid metabolism
ssc00564  Glycerophospholipid metabolism
ssc00600  Sphingolipid metabolism
ssc00620  Pyruvate metabolism
ssc00630  Glyoxylate and dicarboxylate metabolism
ssc00640  Propanoate metabolism
ssc00860  Porphyrin metabolism
ssc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system