KEGG   PATHWAY: thj03013
Entry
thj03013                    Pathway                                
Name
Nucleocytoplasmic transport - Tarenaya hassleriana (spider flower)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
thj03013  Nucleocytoplasmic transport
thj03013

Other DBs
GO: 0050658
Organism
Tarenaya hassleriana (spider flower) [GN:thj]
Gene
104814894  LOW QUALITY PROTEIN: aladin [KO:K14320]
104809224  zinc finger CCCH domain-containing protein 16 [KO:K14321]
104805269  protein GLE1 isoform X1 [KO:K18723]
104805142  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
104813581  protein RAE1 [KO:K14298]
104812445  protein RAE1 [KO:K14298]
104806451  nuclear pore complex protein NUP98A isoform X1 [KO:K14297]
104812443  nuclear pore complex protein NUP96 [KO:K14297]
104822690  nuclear pore complex protein NUP214 isoform X1 [KO:K14317]
104826852  nuclear pore complex protein NUP88 isoform X1 [KO:K14318]
104818782  RAN GTPase-activating protein 2 [KO:K14319]
104823049  RAN GTPase-activating protein 1-like [KO:K14319]
104802422  SUMO-conjugating enzyme SCE1 [KO:K10577]
104801429  SUMO-conjugating enzyme SCE1-like [KO:K10577]
104819590  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
104806485  nuclear pore complex protein NUP160 [KO:K14303]
104803757  nuclear pore complex protein NUP85 isoform X1 [KO:K14304]
104802411  protein transport protein SEC13 homolog B-like [KO:K14004]
104821058  protein transport protein SEC13 homolog B [KO:K14004]
104822379  protein transport protein SEC13 homolog B-like [KO:K14004]
104822664  nuclear pore complex protein NUP107 [KO:K14301]
104815358  nuclear pore complex protein NUP133 isoform X1 [KO:K14300]
104823610  protein SEH1 [KO:K14299]
104803556  nuclear pore complex protein NUP43 [KO:K14305]
104802481  nuclear pore complex protein NUP62 [KO:K14306]
104819823  nuclear pore complex protein NUP58 isoform X1 [KO:K14307]
104825515  nuclear pore complex protein NUP54 [KO:K14308]
104808989  nuclear pore complex protein NUP205 [KO:K14310]
104824773  uncharacterized protein LOC104824773 isoform X1 [KO:K14311]
104823681  nuclear pore complex protein NUP155 [KO:K14312]
104817509  nuclear pore complex protein NUP93A [KO:K14309]
104817965  nuclear pore complex protein NUP35 [KO:K14313]
104810627  uncharacterized protein LOC104810627 [KO:K14315]
104805370  nuclear pore complex protein GP210 [KO:K14314]
104827150  uncharacterized protein LOC104827150 isoform X1 [KO:K20724]
104813306  nuclear-pore anchor [KO:K09291]
104814292  uncharacterized protein LOC104814292 isoform X1 [KO:K14295]
104806368  uncharacterized protein LOC104806368 isoform X1 [KO:K14295]
104802779  importin subunit alpha-7 [KO:K15042]
104801294  importin subunit alpha isoform X1 [KO:K15042]
104825950  importin subunit alpha-3-like [KO:K15042]
104818897  importin subunit alpha-1 [KO:K15042]
104820584  importin subunit alpha-4 [KO:K15042]
104820277  importin subunit alpha-2-like [KO:K15042]
104821791  importin subunit alpha-2 [KO:K15042]
104827087  importin subunit alpha-1-like [KO:K15042]
104816862  importin subunit alpha-4 [KO:K15042]
104816324  importin subunit alpha-9 [KO:K15042]
104811908  importin subunit beta-1 [KO:K14293]
104823298  importin subunit beta-1 [KO:K14293]
104804319  transportin-1-like [KO:K18752]
104819659  transportin-1 [KO:K18752]
104805290  transportin MOS14 [KO:K15436]
104818250  transportin MOS14 isoform X1 [KO:K15436]
104819430  transportin MOS14 [KO:K15436]
104805711  importin-4 [KO:K20221]
104811074  importin-5-like [KO:K20222]
104805768  importin-5-like [KO:K20222]
104807532  importin-5-like isoform X1 [KO:K20222]
104803420  importin beta-like SAD2 homolog isoform X1 [KO:K20223]
104800912  importin beta-like SAD2 [KO:K20223]
104815866  importin beta-like SAD2 isoform X1 [KO:K20223]
104808446  importin-9 [KO:K20224]
104823290  importin-11 [KO:K25201]
104825016  snurportin-1 isoform X1 [KO:K13151]
104802918  protein EXPORTIN 1A-like [KO:K14290]
104820879  protein EXPORTIN 1A [KO:K14290]
104817368  exportin-2 [KO:K18423]
104808055  exportin-T [KO:K14288]
104812251  exportin-T isoform X1 [KO:K14288]
104827286  exportin-4 isoform X1 [KO:K25203]
104821698  protein HASTY 1 [KO:K14289]
104826824  exportin-7-like isoform X1 [KO:K18460]
104816588  exportin-7 isoform X1 [KO:K18460]
104799654  GTP-binding nuclear protein Ran-3 [KO:K07936]
104815105  GTP-binding nuclear protein Ran-3 [KO:K07936]
104811044  GTP-binding nuclear protein Ran-3-like [KO:K07936]
104810843  elongation factor 1-alpha [KO:K03231]
104800469  elongation factor 1-alpha [KO:K03231]
104800612  elongation factor 1-alpha-like [KO:K03231]
104814836  elongation factor 1-alpha [KO:K03231]
104815750  elongation factor 1-alpha-like [KO:K03231]
104815751  elongation factor 1-alpha-like [KO:K03231]
104826360  elongation factor 1-alpha-like [KO:K03231]
104826361  elongation factor 1-alpha-like [KO:K03231]
104811250  uncharacterized protein LOC104811250 [KO:K14291]
104800443  nuclear cap-binding protein subunit 1 [KO:K12882]
104801162  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
104805980  60S ribosomal export protein NMD3-like [KO:K07562]
104800459  60S ribosomal export protein NMD3-like [KO:K07562]
104805642  60S ribosomal export protein NMD3-like [KO:K07562]
104805649  60S ribosomal export protein NMD3-like [KO:K07562]
104805650  60S ribosomal export protein NMD3-like [KO:K07562]
104817916  RNA-binding protein 8A-B-like [KO:K12876]
104816872  RNA-binding protein 8A-B isoform X1 [KO:K12876]
104811180  RNA-binding protein 8A-B-like [KO:K12876]
104801496  protein mago nashi homolog [KO:K12877]
104816996  protein mago nashi homolog [KO:K12877]
104814107  LOW QUALITY PROTEIN: protein mago nashi homolog [KO:K12877]
104826525  DEAD-box ATP-dependent RNA helicase 2 [KO:K13025] [EC:5.6.2.7]
104815234  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 2-like [KO:K13025] [EC:5.6.2.7]
104807709  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
104824862  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
104802003  histone deacetylase complex subunit SAP18 [KO:K14324]
104813616  serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325]
104805935  pinin [KO:K13114]
104827008  THO complex subunit 4B-like [KO:K12881]
104822306  THO complex subunit 4D isoform X1 [KO:K12881]
104823255  LOW QUALITY PROTEIN: THO complex subunit 4B-like [KO:K12881]
104823841  THO complex subunit 4D-like [KO:K12881]
104816286  THO complex subunit 4B [KO:K12881]
104798343  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104806689  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104809987  regulator of nonsense transcripts UPF2 [KO:K14327]
104806760  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
104815973  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
104799232  DEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
104798662  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
104825180  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
104800686  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104809537  partner of Y14 and mago [KO:K14294]
104826748  THO complex subunit 1 isoform X1 [KO:K12878]
104807876  THO complex subunit 2-like [KO:K12879]
104825570  THO complex subunit 2 [KO:K12879]
104812571  THO complex subunit 5B [KO:K13174]
104822853  THO complex subunit 5B isoform X1 [KO:K13174]
104814631  THO complex subunit 6 [KO:K13175]
104820896  THO complex subunit 7A [KO:K13176]
104813462  THO complex subunit 3-like [KO:K12880]
104811694  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
thj03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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