KEGG   PATHWAY: uah00260
Entry
uah00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ursus arctos (brown bear)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
uah00260  Glycine, serine and threonine metabolism
uah00260

Module
uah_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:uah00260]
uah_M00047  Creatine pathway [PATH:uah00260]
uah_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:uah00260]
uah_M00555  Betaine biosynthesis, choline => betaine [PATH:uah00260]
uah_M00621  Glycine cleavage system [PATH:uah00260]
uah_M00974  Betaine metabolism, animals, betaine => glycine [PATH:uah00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113244568  uncharacterized protein LOC113244568 [KO:K01620] [EC:4.1.2.48]
113271286  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
113256389  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
113249581  AGXT; alanine--glyoxylate aminotransferase isoform X2 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113260446  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
113256948  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
113257974  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
113251781  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
113264369  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
113244360  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113269827  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
113267735  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
113241796  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
113270031  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
123002003  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
113248664  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
113256943  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
113265899  uncharacterized protein LOC113265899 [KO:K00274] [EC:1.4.3.4]
113265900  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
113250055  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
113265394  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
113260623  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
113256872  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
113258483  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
113263161  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
113252527  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
113267077  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
113260880  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113269569  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
113242729  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
113256982  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
113261663  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
113255170  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
113254981  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
113269058  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113266576  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
113261284  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
113254145  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
113254538  CTH; cystathionine gamma-lyase isoform X2 [KO:K01758] [EC:4.4.1.1]
113266997  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
113266998  SDSL; serine dehydratase-like isoform X3 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
113269141  SRR; serine racemase isoform X2 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
uah00010  Glycolysis / Gluconeogenesis
uah00020  Citrate cycle (TCA cycle)
uah00230  Purine metabolism
uah00250  Alanine, aspartate and glutamate metabolism
uah00270  Cysteine and methionine metabolism
uah00290  Valine, leucine and isoleucine biosynthesis
uah00330  Arginine and proline metabolism
uah00470  D-Amino acid metabolism
uah00564  Glycerophospholipid metabolism
uah00600  Sphingolipid metabolism
uah00620  Pyruvate metabolism
uah00630  Glyoxylate and dicarboxylate metabolism
uah00640  Propanoate metabolism
uah00860  Porphyrin metabolism
uah00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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