KEGG   PATHWAY: uah00760
Entry
uah00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Ursus arctos horribilis (North American brown bear)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
uah00760  Nicotinate and nicotinamide metabolism
uah00760

Module
uah_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:uah00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113247280  ASPDH; putative L-aspartate dehydrogenase isoform X1 [KO:K06989] [EC:1.4.1.21]
113267672  QPRT; nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1 [KO:K00767] [EC:2.4.2.19]
113247656  NAPRT; nicotinate phosphoribosyltransferase isoform X1 [KO:K00763] [EC:6.3.4.21]
113248957  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
113269843  NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
113271305  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
113268245  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
113244644  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
113270176  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
113251884  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
113268136  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
113261050  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
113270528  NMNAT1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
113253997  NMNAT3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
113262581  NMNAT2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
113259449  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113259450  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113255022  NUDT12; peroxisomal NADH pyrophosphatase NUDT12 isoform X1 [KO:K03426] [EC:3.6.1.22]
113259171  NUDT13; nucleoside diphosphate-linked moiety X motif 13 isoform X1 [KO:K03426] [EC:3.6.1.22]
113243973  NADSYN1; glutamine-dependent NAD(+) synthetase isoform X1 [KO:K01950] [EC:6.3.5.1]
113258637  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
113266704  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
113266702  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
113269029  SARM1; sterile alpha and TIR motif-containing protein 1 [KO:K27536] [EC:3.2.2.6]
113259105  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
113243599  SIRT2; NAD-dependent protein deacetylase sirtuin-2 isoform X1 [KO:K11412] [EC:2.3.1.286]
113248769  SIRT3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1 [KO:K11413] [EC:2.3.1.286]
113267037  SIRT4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1 [KO:K11414] [EC:2.3.1.286 2.3.1.313]
113264471  SIRT5; NAD-dependent protein deacylase sirtuin-5, mitochondrial [KO:K11415] [EC:2.3.1.286]
113242824  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
113244493  SIRT7; NAD-dependent protein deacetylase sirtuin-7 isoform X1 [KO:K11417] [EC:2.3.1.286]
113270619  NADK; NAD kinase isoform X1 [KO:K00858] [EC:2.7.1.23]
113260897  NADK2; NAD kinase 2, mitochondrial isoform X1 [KO:K00858] [EC:2.7.1.23]
113260959  NNT; NAD(P) transhydrogenase, mitochondrial [KO:K00323] [EC:7.1.1.1]
113260035  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
113250605  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
113250606  aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
113250607  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
uah00020  Citrate cycle (TCA cycle)
uah00250  Alanine, aspartate and glutamate metabolism
uah00380  Tryptophan metabolism
uah00620  Pyruvate metabolism
KO pathway
ko00760   
LinkDB

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