Entry Name Hedgehog signaling pathway - Xenopus laevis (African clawed frog)
Description The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Xenopus laevis (African clawed frog) [GN:
xla ]
Gene 100126618 lrp2.L; low-density lipoprotein receptor-related protein 2 isoform X1 [KO:K06233 ]
100190780 smo.L; smoothened, frizzled class receptor L homeolog precursor [KO:K06226 ]
100381032 scube2.L; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2 [KO:K24706 ]
108696705 megf8.L; multiple epidermal growth factor-like domains protein 8 [KO:K23664 ]
108697576 cdon.S; cell adhesion molecule-related/down-regulated by oncogenes-like isoform X1 [KO:K20033 ]
108697768 megf8.S; multiple epidermal growth factor-like domains protein 8 [KO:K23664 ]
108715299 scube2.S; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2 [KO:K24706 ]
108716437 hhat.L; protein-cysteine N-palmitoyltransferase HHAT isoform X1 [KO:K24678 ]
108718700 hhatl.L; protein-cysteine N-palmitoyltransferase HHAT-like protein [KO:K24679 ]
373711 cdon.L; cell adhesion molecule-related/down-regulated by oncogenes precursor [KO:K20033 ]
378538 dhh.L; desert hedgehog protein A precursor [KO:K11990 ]
378539 dhh.S; desert hedgehog protein B precursor [KO:K11990 ]
379179 hhatl.S; hedgehog acyltransferase like S homeolog [KO:K24679 ]
379458 mosmo.L; uncharacterized protein C16orf52 homolog B [KO:K23663 ]
380097 hhip.L; hedgehog interacting protein L homeolog precursor [KO:K06231 ]
380388 prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345 ] [EC:2.7.11.11 ]
398107 gli2.S; GLI family zinc finger 2 S homeolog [KO:K16798 ]
398216 smo.S; smoothened, frizzled class receptor S homeolog [KO:K06226 ]
398350 gli1.S; zinc finger protein GLI1 isoform X1 [KO:K16797 ]
398990 mgrn1.S; mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog [KO:K10604 ] [EC:2.3.2.27 ]
399401 kif3a.L; kinesin family member 3A L homeolog [KO:K10394 ]
443556 boc.L; BOC cell adhesion associated, oncogene regulated L homeolog precursor [KO:K20020 ]
443762 mosmo.S; uncharacterized protein C16orf52 homolog A [KO:K23663 ]
444442 sufu.L; SUFU negative regulator of hedgehog signaling L homeolog [KO:K06229 ]
447043 efcab7.L; EF-hand calcium-binding domain-containing protein 7 [KO:K23852 ]
734526 cul1.L; uncharacterized protein LOC734526 [KO:K03347 ]
Compound Reference Authors Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
Title Hedgehog receptor function during craniofacial development.
Journal Reference Authors Briscoe J, Therond PP
Title The mechanisms of Hedgehog signalling and its roles in development and disease.
Journal Reference Authors Alman BA
Title The role of hedgehog signalling in skeletal health and disease.
Journal Reference Authors Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
Title Hedgehog and Resident Vascular Stem Cell Fate.
Journal Reference Authors Sasai N, Briscoe J
Title Primary cilia and graded Sonic Hedgehog signaling.
Journal Reference Authors Heretsch P, Tzagkaroulaki L, Giannis A
Title Modulators of the hedgehog signaling pathway.
Journal Reference Authors Anderson E, Peluso S, Lettice LA, Hill RE
Title Human limb abnormalities caused by disruption of hedgehog signaling.
Journal Reference Authors Rohatgi R, Scott MP
Title Cell biology. Arrestin' movement in cilia.
Journal Reference Authors Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
Title Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
Journal Reference Authors Ok CY, Singh RR, Vega F
Title Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
Journal Reference Authors Hsia EY, Gui Y, Zheng X
Title Regulation of Hedgehog signaling by ubiquitination.
Journal Reference Authors Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
Title CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Journal Reference Authors Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R
Title EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
Journal Reference Authors Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW
Title Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
Journal Related KO pathway
