KEGG   PATHWAY: xla04120
Entry
xla04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Xenopus laevis (African clawed frog)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
xla04120  Ubiquitin mediated proteolysis
xla04120

Other DBs
GO: 0016567
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
379276  ubb.L; ubiquitin B L homeolog [KO:K08770]
108716425  polyubiquitin-C [KO:K08770]
108707155  ubc.S; polyubiquitin-C [KO:K08770]
108707934  polyubiquitin-C [KO:K08770]
443882  uba52.L; ubiquitin A-52 residue ribosomal protein fusion product 1 L homeolog [KO:K02927]
108706905  ubiquitin-60S ribosomal protein L40 [KO:K02927]
444494  rps27a.S; ribosomal protein S27a S homeolog [KO:K02977]
108716411  rps27a.L; ubiquitin-40S ribosomal protein S27a [KO:K02977]
379877  uba1.S; ubiquitin-activating enzyme E1 [KO:K03178] [EC:6.2.1.45]
398370  uba1.L; ubiquitin-like modifier activating enzyme 1 L homeolog [KO:K03178] [EC:6.2.1.45]
443558  sae1.L; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
399235  uba2.L; ubiquitin like modifier activating enzyme 2 L homeolog [KO:K10685] [EC:6.2.1.45]
108704086  uba2.S; SUMO-activating enzyme subunit 2-A-like isoform X1 [KO:K10685] [EC:6.2.1.45]
734782  uba3.S; ubiquitin like modifier activating enzyme 3 S homeolog [KO:K10686] [EC:6.2.1.64]
108714725  uba3.L; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
108719700  uba6.L; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
398788  ube2a.L; ubiquitin conjugating enzyme E2 A L homeolog [KO:K10573] [EC:2.3.2.23]
108700138  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
443745  ube2b.S; ubiquitin conjugating enzyme E2 B S homeolog [KO:K10574] [EC:2.3.2.23]
108710808  ube2b.L; ubiquitin-conjugating enzyme E2 B isoform X1 [KO:K10574] [EC:2.3.2.23]
444775  ube2c.L; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
496302  ube2c.S; ubiquitin conjugating enzyme E2 C S homeolog [KO:K06688] [EC:2.3.2.23]
108712728  ube2d4.S; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
108697361  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
100101299  ube2d4.L; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
403384  ube2d3.L; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
446340  ube2d1.L; ubiquitin conjugating enzyme E2 D1 L homeolog [KO:K06689] [EC:2.3.2.23]
108706735  ube2d3.S; ubiquitin-conjugating enzyme E2 D2 isoform X2 [KO:K06689] [EC:2.3.2.23]
403382  ube2e3.S; ubiquitin conjugating enzyme E2 E3 S homeolog [KO:K20217] [EC:2.3.2.23]
494590  ube2e2; ubiquitin-conjugating enzyme E2E 2 [KO:K20217] [EC:2.3.2.23]
494592  ube2e1.L; ubiquitin conjugating enzyme E2 E1 L homeolog [KO:K20217] [EC:2.3.2.23]
494742  ube2e2.S; ubiquitin conjugating enzyme E2E 2 S homeolog [KO:K20217] [EC:2.3.2.23]
494805  ube2e2.L; ubiquitin conjugating enzyme E2E 2 L homeolog [KO:K20217] [EC:2.3.2.23]
779114  ube2e3.L; ubiquitin conjugating enzyme E2 E3 L homeolog [KO:K20217] [EC:2.3.2.23]
432085  ube2f.S; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
108701421  NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
380500  ube2g1.S; ubiquitin conjugating enzyme E2 G1 S homeolog [KO:K10575] [EC:2.3.2.23]
108708357  ube2g1.L; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
446360  ube2g2.L; ubiquitin conjugating enzyme E2 G2 L homeolog [KO:K04555] [EC:2.3.2.23]
380288  ube2h.L; ubiquitin conjugating enzyme E2 H L homeolog [KO:K10576] [EC:2.3.2.23]
108713030  ube2h.S; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
380450  ube2i.L; SUMO-conjugating enzyme UBC9 [KO:K10577]
108703134  ube2i.S; SUMO-conjugating enzyme UBC9 [KO:K10577]
100049091  ube2j1.L; ubiquitin conjugating enzyme E2 J1 L homeolog [KO:K10578] [EC:2.3.2.23]
108717973  ube2j1.S; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
495424  ube2j2.L; ubiquitin conjugating enzyme E2 J2 L homeolog [KO:K04554] [EC:2.3.2.23]
108697639  ube2j2.S; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
379982  ube2k.S; ubiquitin conjugating enzyme E2 K S homeolog [KO:K04649] [EC:2.3.2.23]
108698072  ube2k.L; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
446231  ube2l3.S; ubiquitin conjugating enzyme E2 L3 S homeolog [KO:K04552] [EC:2.3.2.23]
108716049  ube2l3.L; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
446800  ube2m.L; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108697716  ube2m.S; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
380524  ube2n.S; ubiquitin conjugating enzyme E2 N S homeolog [KO:K10580] [EC:2.3.2.23]
108711058  ube2n.L; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
108701078  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X3 [KO:K10581] [EC:2.3.2.24]
108701130  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X1 [KO:K10581] [EC:2.3.2.24]
108702822  ube2o.S; (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O [KO:K10581] [EC:2.3.2.24]
398940  ube2q2.L; ubiquitin conjugating enzyme E2Q family member 2 L homeolog [KO:K10582] [EC:2.3.2.23]
108720036  ube2ql1.S; ubiquitin-conjugating enzyme E2Q-like protein CG4502 [KO:K10582] [EC:2.3.2.23]
108719074  ube2ql1.L; ubiquitin-conjugating enzyme E2Q-like protein CG4502 [KO:K10582] [EC:2.3.2.23]
108713009  ube2q2.S; ubiquitin-conjugating enzyme E2 Q2 [KO:K10582] [EC:2.3.2.23]
379298  cdc34.L; cell division cycle 34 L homeolog [KO:K02207] [EC:2.3.2.23]
380226  ube2r2; ubiquitin coniugating enzyme 3b [KO:K02207] [EC:2.3.2.23]
108705456  ube2r2.L; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
108706898  cdc34.S; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
403383  ube2s.L; ubiquitin-conjugating enzyme E2 S-C [KO:K10583] [EC:2.3.2.23]
379075  ube2s.S; ubiquitin-conjugating enzyme E2 S-B [KO:K10583] [EC:2.3.2.23]
108714226  ube2u.L; ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
108705626  ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108695347  ube2w.S; ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121394743  ubiquitin-conjugating enzyme E2 W-like [KO:K10688] [EC:2.3.2.23 2.3.2.25]
379726  ube2z.S; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
108700811  ube2z.L; ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
108717825  birc6.S; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
108716679  birc6.L; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
108708430  ube3a.L; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
380385  ube3a.S; ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog [KO:K10587] [EC:2.3.2.26]
100381000  ube3b.L; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
108707075  ube3b.S; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
108718743  ube3c.L; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
380493  ube3c.S; ubiquitin protein ligase E3C S homeolog [KO:K10589] [EC:2.3.2.26]
398131  smurf1.L; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
398372  smurf2.S; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
108701209  E3 ubiquitin-protein ligase SMURF2-like isoform X2 [KO:K04678] [EC:2.3.2.26]
108703087  smurf1.S; E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
108701064  E3 ubiquitin-protein ligase Itchy [KO:K05632] [EC:2.3.2.26]
108702762  E3 ubiquitin-protein ligase Itchy [KO:K05632] [EC:2.3.2.26]
108719322  wwp1.L; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
108695372  wwp1.S; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
108714062  wwp2.L; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
108715425  wwp2.S; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
414478  trip12.S; uncharacterized protein LOC414478 [KO:K10590] [EC:2.3.2.26]
108717128  trip12.L; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
108712929  nedd4.S; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
108711373  nedd4.L; E3 ubiquitin-protein ligase NEDD4 isoform X4 [KO:K10591] [EC:2.3.2.26]
399396  nedd4l.S; NEDD4 like E3 ubiquitin protein ligase S homeolog [KO:K13305] [EC:2.3.2.26]
108718432  nedd4l.L; E3 ubiquitin-protein ligase NEDD4-like isoform X4 [KO:K13305] [EC:2.3.2.26]
108699996  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
108704466  E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
108695408  ubr5.S; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
108719366  ubr5.L; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
108711287  herc1.L; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
108708436  herc2.L; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
108709727  herc2.S; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
444030  herc3.L; HECT and RLD domain containing E3 ubiquitin protein ligase 3 L homeolog [KO:K10614] [EC:2.3.2.26]
446573  herc4.S; probable E3 ubiquitin-protein ligase HERC4 isoform X2 [KO:K10615] [EC:2.3.2.26]
495281  herc4.L; probable E3 ubiquitin-protein ligase HERC4 isoform X2 [KO:K10615] [EC:2.3.2.26]
414451  ube4a.S; ubiquitination factor E4A S homeolog [KO:K10596] [EC:2.3.2.27]
108696459  ube4a.L; ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
108696352  ube4b.L; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
733415  stub1.L; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108703244  stub1.S; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
379271  ppil2.S; peptidylprolyl isomerase-like 2 [KO:K10598] [EC:5.2.1.8]
380586  prpf19.L; pre-mRNA processing factor 19 L homeolog [KO:K10599] [EC:2.3.2.27]
108697536  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
495687  ubox5.S; U-box domain containing 5 S homeolog [KO:K10600]
108713153  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108711092  mdm2.L; E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
398194  cbl.L; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
108705407  cbl.S; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
431829  cblb.S; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
443854  cblb.L; E3 ubiquitin-protein ligase CBL-B-A [KO:K22517] [EC:2.3.2.27]
108697772  cblc.S; E3 ubiquitin-protein ligase CBL [KO:K22518] [EC:2.3.2.27]
443864  siah1.L; siah E3 ubiquitin protein ligase 1 L homeolog [KO:K04506] [EC:2.3.2.27]
108715479  siah1.S; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
444777  traf6.L; TNF receptor-associated factor 6-B [KO:K03175] [EC:2.3.2.27]
734929  traf6.S; TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
108704427  map3k1.S; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108718321  map3k1.L; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100158422  cop1.L; E3 ubiquitin-protein ligase COP1 isoform X2 [KO:K10143] [EC:2.3.2.27]
108715625  cop1.S; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
496013  rchy1.L; ring finger and CHY zinc finger domain containing 1 L homeolog [KO:K10144] [EC:2.3.2.27]
100036859  birc2.S; uncharacterized protein LOC100036859 [KO:K16060]
446568  birc2.L; baculoviral IAP repeat containing 2 L homeolog [KO:K16060]
733235  xiap.L; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
398387  birc7.S; baculoviral IAP repeat-containing protein 7-A [KO:K16061]
108702033  baculoviral IAP repeat-containing protein 7-B isoform X1 [KO:K16061]
373715  pias1.L; protein inhibitor of activated STAT 1 L homeolog [KO:K04706] [EC:2.3.2.-]
108712799  pias1.S; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
432031  pias2.L; protein inhibitor of activated STAT 2 L homeolog [KO:K16063] [EC:2.3.2.-]
108707347  pias2.S; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
444507  pias3.L; protein inhibitor of activated STAT 3 L homeolog [KO:K16064] [EC:2.3.2.-]
108700613  pias3.S; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
494663  pias4.L; protein inhibitor of activated STAT 4 L homeolog [KO:K16065] [EC:2.3.2.27]
398703  pias4.S; protein inhibitor of activated STAT 4 S homeolog [KO:K16065] [EC:2.3.2.27]
431869  syvn1.L; E3 ubiquitin-protein ligase synoviolin A [KO:K10601] [EC:2.3.2.27]
494996  syvn1.S; E3 ubiquitin-protein ligase synoviolin B [KO:K10601] [EC:2.3.2.27]
108718744  nhlrc1.L; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
100127244  aire.L; autoimmune regulator [KO:K10603]
398990  mgrn1.S; mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog [KO:K10604] [EC:2.3.2.27]
399391  brca1.L; breast cancer 1 L homeolog [KO:K10605] [EC:2.3.2.27]
734197  fancl.L; FA complementation group L L homeolog [KO:K10606] [EC:2.3.2.27]
100463496  mid1.L; midline 1 L homeolog [KO:K08285] [EC:2.3.2.27]
108709429  mid1.S; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
108698295  trim32.L; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
108709630  trim37.S; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
108708315  trim37.L; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
108714482  rbx1.L; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108715730  rbx1.S; RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
734414  cul1.S; cullin 1 S homeolog [KO:K03347]
734526  cul1.L; uncharacterized protein LOC734526 [KO:K03347]
380538  skp1.L; S-phase kinase-associated protein 1 [KO:K03094]
108712619  skp1.S; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
394362  btrc.S; beta-TrCP [KO:K03362]
397988  btrc.L; beta-TrCP-like isoform X1 [KO:K03362]
734901  skp2.L; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase L homeolog [KO:K03875]
734599  MGC115598; uncharacterized protein LOC734599 [KO:K10260]
734230  fbxw7.L; F-box and WD repeat domain containing 7 L homeolog [KO:K10260]
108715314  F-box/WD repeat-containing protein 7 [KO:K10260]
108715316  F-box/WD repeat-containing protein 7 [KO:K10260]
108713709  F-box/WD repeat-containing protein 7-like [KO:K10260]
108713714  F-box/WD repeat-containing protein 7 [KO:K10260]
108706660  F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
108697559  fbxo2.S; F-box only protein 2 isoform X1 [KO:K10099]
100158284  fbxo4.L; F-box protein 4 L homeolog [KO:K10291]
379729  cul2.L; cullin 2 L homeolog [KO:K03870]
108719839  cul2.S; cullin-2 isoform X1 [KO:K03870]
379820  eloc.L; elongin C L homeolog [KO:K03872]
108695349  elongin-C [KO:K03872]
108719192  elongin-C [KO:K03872]
108705708  elongin-C [KO:K03872]
380106  elob.L; elongin B L homeolog [KO:K03873]
108703269  elongin-B isoform X1 [KO:K03873]
108714636  vhl.L; von Hippel-Lindau disease tumor suppressor [KO:K03871]
121393137  von Hippel-Lindau disease tumor suppressor-like [KO:K03871]
446487  cul3.L; cullin-3-A [KO:K03869]
444103  cul3.S; cullin-3-B [KO:K03869]
496326  keap1.L; kelch like ECH associated protein 1 L homeolog [KO:K10456]
108713336  keap1.S; kelch-like ECH-associated protein 1 [KO:K10456]
108713230  kelch-like ECH-associated protein 1A [KO:K10456]
108706903  kelch-like ECH-associated protein 1A [KO:K10456]
446546  klhl13.L; kelch like family member 13 L homeolog [KO:K10447]
108700169  klhl13.S; kelch-like protein 13 isoform X3 [KO:K10447]
108698156  klhl9.L; kelch-like protein 9 [KO:K10447]
444105  rhobtb1.S; Rho related BTB domain containing 1 S homeolog [KO:K07868]
108712692  rhobtb2.S; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
108711624  rhobtb2.L; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
108706470  rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
108696080  rhobtb1.L; rho-related BTB domain-containing protein 1 [KO:K07868]
108704855  rho-related BTB domain-containing protein 2-like [KO:K07868]
735163  cul4b.S; cullin 4B S homeolog [KO:K10609]
108698360  cul4b.L; cullin-4B isoform X1 [KO:K10609]
108708452  cul4a.L; cullin-4A [KO:K10609]
100158294  cul4a.S; cullin-4A [KO:K10609]
399026  ddb1.S; DNA damage-binding protein 1 [KO:K10610]
108713786  ddb2.L; DNA damage-binding protein 2 [KO:K10140]
108715228  ddb2.S; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
496353  ercc8.S; excision repair cross-complementation group 8 S homeolog [KO:K10570]
444462  det1.L; DET1, COP1 ubiquitin ligase partner L homeolog [KO:K10571]
414491  rnf7.L; ring finger protein 7 L homeolog [KO:K10611]
100126611  cul5.L; cullin 5 L homeolog [KO:K10612]
108709992  cul5.S; cullin-5 isoform X1 [KO:K10612]
443921  socs1.S; suppressor of cytokine signaling 1 S homeolog [KO:K04694]
100294520  socs1.L; suppressor of cytokine signaling 1 L homeolog [KO:K04694]
108715012  suppressor of cytokine signaling 1 [KO:K04694]
380467  socs3.S; suppressor of cytokine signaling 3 S homeolog [KO:K04696]
100158303  socs3l.S; uncharacterized protein LOC100158303 [KO:K04696]
414533  socs3.L; suppressor of cytokine signaling 3 L homeolog [KO:K04696]
108696746  socs3l.L; suppressor of cytokine signaling 3 [KO:K04696]
444104  fbxw8.L; F-box and WD repeat domain containing 8 L homeolog [KO:K10264]
496247  anapc11.L; anaphase promoting complex subunit 11 L homeolog [KO:K03358]
100310821  anapc2.L; anaphase-promoting complex subunit 2 [KO:K03349]
379130  cdc20.S; cell division cycle 20 S homeolog [KO:K03363]
398044  cdc20.L; cell division cycle 20 L homeolog [KO:K03363]
380351  fzr1.L; fizzy/cell division cycle 20 related 1 L homeolog [KO:K03364]
108717771  anapc1.S; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
443994  cdc27.S; cell division cycle protein 27 homolog [KO:K03350]
108700852  cdc27.L; cell division cycle protein 27 homolog [KO:K03350]
414530  anapc4.L; anaphase promoting complex subunit 4 L homeolog [KO:K03351]
779325  anapc5.L; anaphase promoting complex subunit 5 L homeolog [KO:K03352]
446982  cdc16.L; cell division cycle 16 L homeolog [KO:K03353]
446574  anapc7.L; anaphase promoting complex subunit 7 L homeolog [KO:K03354]
447726  anapc7.S; anaphase promoting complex subunit 7 S homeolog [KO:K03354]
379580  cdc23.L; cell division cycle 23 L homeolog [KO:K03355]
380068  cdc23.S; cell division cycle 23 S homeolog [KO:K03355]
595046  anapc10.L; uncharacterized protein LOC595046 [KO:K03357]
734319  anapc10.S; anaphase promoting complex subunit 10 S homeolog [KO:K03357]
108698127  cdc26.L; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100037155  anapc13.2.L; anaphase promoting complex subunit 13, gene 2 L homeolog [KO:K12456]
432025  anapc15.S; anaphase-promoting complex subunit 15A [KO:K25228]
734832  anapc15.L; anaphase-promoting complex subunit 15B [KO:K25228]
108697486  anapc16.S; anaphase-promoting complex subunit 16-like [KO:K25229]
443949  anapc16.L; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
xla03050  Proteasome
KO pathway
ko04120   
LinkDB

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