KEGG   PATHWAY: zvi04530
Entry
zvi04530                    Pathway                                
Name
Tight junction - Zootoca vivipara (common lizard)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
zvi04530  Tight junction
zvi04530

Other DBs
GO: 0005923
Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118075183  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
118092236  CLDN12; claudin-12 [KO:K06087]
118081986  CLDN20; claudin-20 [KO:K06087]
118076440  CLDN5; claudin-5 [KO:K06087]
118086969  CLDN19; claudin-19 isoform X1 [KO:K06087]
118093739  CLDN1; claudin-1 [KO:K06087]
118093828  claudin-15-like isoform X1 [KO:K06087]
118094011  CLDN18; claudin-18 isoform X1 [KO:K06087]
118094050  CLDN11; claudin-11 [KO:K06087]
118094078  CLDN16; claudin-16 [KO:K06087]
118094766  CLDN15; claudin-15 [KO:K06087]
118094914  claudin-9-like [KO:K06087]
118094915  claudin-4-like [KO:K06087]
118089655  claudin-34-like [KO:K06087]
118095269  CLDN7; claudin-7 [KO:K06087]
118084500  claudin-22-like [KO:K06087]
118084563  CLDN2; claudin-2 [KO:K06087]
118084642  CLDN10; claudin-10 isoform X1 [KO:K06087]
118085287  claudin-8-like [KO:K06087]
118096705  claudin-4-like [KO:K06087]
118096706  claudin-4-like [KO:K06087]
118085508  CLDN14; claudin-14 [KO:K06087]
118085576  claudin-8-like [KO:K06087]
118096861  CLDN25; putative claudin-25 [KO:K06087]
118097338  claudin-3-like [KO:K06087]
118097797  CLDN23; claudin-23 [KO:K06087]
118086821  claudin-16-like [KO:K06087]
118086822  claudin-16-like [KO:K06087]
118076696  OCLN; occludin isoform X1 [KO:K06088]
118087287  occludin-like isoform X1 [KO:K06088]
118075885  F11R; junctional adhesion molecule A [KO:K06089]
118084830  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
118097273  JAM3; junctional adhesion molecule C [KO:K06785]
118082222  BVES; blood vessel epicardial substance [KO:K21108]
118086883  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118087493  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
118089088  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118089955  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118084390  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
118096063  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
118086477  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
118088727  PATJ; inaD-like protein isoform X1 [KO:K06092]
118097650  MPDZ; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
118085893  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118093637  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
118084190  AMOT; angiomotin [KO:K16819]
118093687  AMOTL2; angiomotin-like protein 2 [KO:K06104]
118085200  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
118092708  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
118092637  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118097420  merlin-like isoform X1 [KO:K16684]
118079833  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
118093301  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
118094082  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
118078696  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
118097627  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118086500  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118080314  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118084412  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
118096216  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118096714  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118091734  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118085763  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118093068  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
118081787  TJAP1; tight junction-associated protein 1 [KO:K06105]
118084710  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
118078801  disks large homolog 3-like [KO:K21098]
118083737  disks large homolog 3 isoform X1 [KO:K21098]
118092633  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118077361  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
118075712  CGN; cingulin [KO:K06102]
118092564  CGNL1; LOW QUALITY PROTEIN: cingulin-like protein 1 [KO:K21110]
118076550  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
118080560  RHOA; transforming protein RhoA [KO:K04513]
118097793  transforming protein RhoA-like [KO:K04513]
118082977  GATA4; transcription factor GATA-4 [KO:K09183]
118087951  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
118090129  MARVEL domain-containing protein 3-like [KO:K21099]
118077342  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
118080395  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118084127  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
118096231  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118089100  JUN; transcription factor AP-1 [KO:K04448]
118080922  antigen-presenting glycoprotein CD1d-like [KO:K06448]
118090952  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
118078968  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118085947  SYMPK; symplekin [KO:K06100]
118087891  PCNA; proliferating cell nuclear antigen [KO:K04802]
118085960  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118094199  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118084720  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
118080328  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
118079799  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
118081967  EZR; ezrin [KO:K08007]
118084862  RDX; radixin isoform X1 [KO:K05762]
118084004  MSN; moesin [KO:K05763]
118083100  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
118077849  actin, cytoplasmic 3-like [KO:K05692]
118079682  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118093697  ACTRT3; actin-related protein T3 [KO:K05692]
118083687  actin, cytoplasmic 3-like [KO:K05692]
118084365  actin, cytoplasmic 3-like [KO:K05692]
118085150  actin, clone 302-like [KO:K05692]
118092538  ACTB; actin, cytoplasmic 1 [KO:K05692]
118080704  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118082069  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118079984  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118088466  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118091427  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
118085870  CTTN; src substrate cortactin [KO:K06106]
118076034  actin-related protein 2-like isoform X1 [KO:K17260]
118082570  ACTR2; actin-related protein 2 [KO:K17260]
118091948  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
118092254  ACTR3; actin-related protein 3 [KO:K18584]
118093051  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
118093318  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
118091213  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
118075814  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
118080890  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
118089230  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
118083871  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
118093156  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
118097687  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
118086273  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
118079980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
118088233  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118076365  RAB13; ras-related protein Rab-13 [KO:K06109]
118085900  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
118089797  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118082382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118087852  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
118094226  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
118086432  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118077126  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118088217  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118076026  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
118078299  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
118078836  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
118090843  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
118091855  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
118079932  MYH10; myosin-10 isoform X1 [KO:K10352]
118093200  MYH11; myosin-11 isoform X1 [KO:K10352]
118094169  myosin-10-like isoform X1 [KO:K10352]
118091419  MYH9; myosin-9 [KO:K10352]
118078787  myosin light polypeptide 6 isoform X1 [KO:K12751]
118078799  myosin light polypeptide 6-like [KO:K12751]
118088978  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118089643  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
118085229  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
118080837  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118080428  SYNPO; synaptopodin isoform X1 [KO:K21112]
118084202  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
118086401  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
118092924  MICALL2; MICAL-like protein 2 [KO:K21068]
118085926  RAB8A; ras-related protein Rab-8A [KO:K07901]
118093315  RAB8B; ras-related protein Rab-8B [KO:K07902]
118080351  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
118089490  RAP1A; ras-related protein Rap-1A [KO:K04353]
118091757  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118081932  AFDN; afadin isoform X1 [KO:K05702]
118076722  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
118083321  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118078247  RAP2C; ras-related protein Rap-2c [KO:K07839]
118076694  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
118087050  OCEL1; occludin/ELL domain-containing protein 1 isoform X1 [KO:K17291]
118079591  tubulin alpha-1C chain-like [KO:K07374]
118079592  tubulin alpha-1C chain [KO:K07374]
118079593  tubulin alpha-1A chain-like [KO:K07374]
118079595  tubulin alpha-1B chain [KO:K07374]
118088270  tubulin alpha-8 chain [KO:K07374]
118094006  tubulin alpha-3 chain [KO:K07374]
118090761  tubulin alpha-1D chain [KO:K07374]
118090764  tubulin alpha chain [KO:K07374]
118091293  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118091384  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
zvi04520  Adherens junction
zvi04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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