KEGG PATHWAY: pcoq00260

PATHWAY: pcoq00260

Entry

pcoq00260                   Pathway

Name

Glycine, serine and threonine metabolism - Propithecus coquereli (Coquerel's sifaka)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

pcoq00260

Glycine, serine and threonine metabolism

Module

pcoq_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:pcoq00260]

pcoq_M00047

Creatine pathway [PATH:pcoq00260]

pcoq_M00555

Betaine biosynthesis, choline => betaine [PATH:pcoq00260]

pcoq_M00621

Glycine cleavage system [PATH:pcoq00260]

pcoq_M00974

Betaine metabolism, animals, betaine => glycine [PATH:pcoq00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]

Gene

105805264

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

105805320

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

105805836

[KO:K15789] [EC:1.1.1.103]

105806038

GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]

105807040

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

105807191

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

105807466

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

105807759

[KO:K12235] [EC:5.1.1.18]

105809033

MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

105809065

MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

105809614

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

105811288

GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]

105812477

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

105812774

[KO:K02437]

105812850

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

105813458

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

105813556

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

105814457

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

105815193

DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]

105815458

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

105815494

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

105815865

[KO:K02437]

105816534

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

105817369

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

105818477

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

105819540

AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]

105820234

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105820243

AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]

105822916

CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

105824253

ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

105824830

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

105825648

SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

105825681

SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

105825694

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

105826344

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

105826497

DMGDH; LOW QUALITY PROTEIN: dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

105826595

BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

105826695

SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]

105826963

SHMT1; LOW QUALITY PROTEIN: serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721