KEGG   PATHWAY: pcoq04727
Entry
pcoq04727                   Pathway                                
Name
GABAergic synapse - Propithecus coquereli (Coquerel's sifaka)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
pcoq04727  GABAergic synapse
pcoq04727

Other DBs
GO: 0051932
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105805290  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105805327  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
105805354  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
105805382  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
105805549  SLC38A2; sodium-coupled neutral amino acid transporter 2 [KO:K14207]
105805554  SLC38A1; sodium-coupled neutral amino acid transporter 1 isoform X1 [KO:K14990]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105806680  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
105806682  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
105806700  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
105806702  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
105806788  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
105806881  KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
105807171  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105807961  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105807995  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
105808086  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
105808688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105808848  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105810759  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
105810760  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
105810761  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105812499  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105812764  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105812915  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
105812917  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
105812945  [KO:K04546]
105813146  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
105813177  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105813276  GLS; glutaminase kidney isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
105813331  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
105813334  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
105813346  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
105813348  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105813715  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105814645  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
105815218  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105815312  [KO:K04857]
105815588  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
105815665  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105815791  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105816577  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
105816656  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105816783  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105816784  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
105816960  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105817197  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
105818188  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105818759  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
105818990  [KO:K05044]
105818991  [KO:K05044]
105818999  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
105819068  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
105819412  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
105819431  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105819866  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820872  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105820917  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
105820923  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
105821123  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105821322  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105822665  HAP1; huntingtin-associated protein 1 [KO:K04647]
105822891  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
105822894  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
105822900  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
105823039  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105826139  [KO:K04849]
105826943  [KO:K04857]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
pcoq00020  Citrate cycle (TCA cycle)
pcoq00250  Alanine, aspartate and glutamate metabolism
pcoq04144  Endocytosis
pcoq04721  Synaptic vesicle cycle
KO pathway
ko04727   

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