KEGG   PATHWAY: pfs00260
Entry
pfs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas fluorescens SBW25
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pfs00260  Glycine, serine and threonine metabolism
pfs00260

Module
pfs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pfs00260]
pfs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pfs00260]
pfs_M00555  Betaine biosynthesis, choline => betaine [PATH:pfs00260]
pfs_M00621  Glycine cleavage system [PATH:pfs00260]
pfs_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pfs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_4747  Aspartate kinase (EC (Aspartokinase) [KO:K00928] [EC:2.7.2.4]
PFLU_4192  Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC (Aspartate-beta-semialdehyde dehydrogenase) [KO:K00133] [EC:1.2.1.11]
PFLU_2011  Homoserine dehydrogenase (EC [KO:K00003] [EC:1.1.1.3]
PFLU_5006  Homoserine dehydrogenase (EC [KO:K00003] [EC:1.1.1.3]
PFLU_0077  thrB; Homoserine kinase (HK) (HSK) (EC [KO:K02204] [EC:2.7.1.39]
PFLU_4641  Putative hydrolase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
PFLU_2009  Putative threonine synthase [KO:K01733] [EC:4.2.3.1]
PFLU_5005  thrC; Threonine synthase (EC [KO:K01733] [EC:4.2.3.1]
PFLU_4749  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PFLU_5654  ltaE; L-threonine aldolase (EC [KO:K01620] [EC:4.1.2.48]
PFLU_5330  glyA; Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC [KO:K00600] [EC:2.1.2.1]
PFLU_5652  glyA; Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC [KO:K00600] [EC:2.1.2.1]
PFLU_0920  hprA; Glycerate dehydrogenase (EC [KO:K00018] [EC:1.1.1.29]
PFLU_4037  Putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PFLU_0968  tkrA; 2-ketogluconate reductase (EC [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
PFLU_3004  Glycerate kinase (EC [KO:K00865] [EC:2.7.1.165]
PFLU_1800  Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PFLU_0337  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PFLU_2307  Putative hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PFLU_5829  serA; 2-oxoglutarate reductase (EC (EC (D-3-phosphoglycerate dehydrogenase) [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PFLU_1644  serC; Phosphoserine aminotransferase (EC (Phosphohydroxythreonine aminotransferase) (PSAT) [KO:K00831] [EC:2.6.1.52]
PFLU_0504  O-phosphoserine phosphohydrolase (EC (Phosphoserine phosphatase) [KO:K01079] [EC:3.1.3.3]
PFLU_0853  Uncharacterized protein [KO:K01079] [EC:3.1.3.3]
PFLU_4065  Putative oxidase [KO:K00274] [EC:1.4.3.4]
PFLU_4897  Glycine dehydrogenase (decarboxylating) (EC (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) [KO:K00281] [EC:1.4.4.2]
PFLU_5874  gcvT; Aminomethyltransferase (EC (Glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
PFLU_4899  Glycine cleavage system T protein (EC [KO:K00605] [EC:2.1.2.10]
PFLU_2330  Putative aminomethyltransferase-like protein [KO:K00605] [EC:2.1.2.10]
PFLU_2333  Putative aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PFLU_1822  lpd; Dihydrolipoyl dehydrogenase (EC [KO:K00382] [EC:1.8.1.4]
PFLU_3967  Dihydrolipoyl dehydrogenase (EC [KO:K00382] [EC:1.8.1.4]
PFLU_5873  gcvH; Glycine cleavage system H protein [KO:K02437]
PFLU_4896  Glycine cleavage system H protein [KO:K02437]
PFLU_2917  CDP-diacylglycerol-serine O-phosphatidyltransferase (EC [KO:K00998] [EC:2.7.8.8]
PFLU_5217  CDP-diacylglycerol--serine O-phosphatidyltransferase (EC (Phosphatidylserine synthase) [KO:K17103] [EC:2.7.8.8]
PFLU_5686  betA; Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC (Betaine aldehyde dehydrogenase) (BADH) (EC [KO:K00108] [EC:1.1.99.1]
PFLU_5685  betB; Betaine aldehyde dehydrogenase (BADH) (EC [KO:K00130] [EC:1.2.1.8]
PFLU_1502  Putative dehydrogenase [KO:K00130] [EC:1.2.1.8]
PFLU_5660  Putative iron/sulfur-binding protein [KO:K00479] [EC:1.14.13.251]
PFLU_5659  Putative iron-sulfur-binding oxidoreductase [KO:K21832] [EC:1.14.13.251]
PFLU_5664  Putative oxidoreductase [KO:K21833] [EC:1.5.7.3]
PFLU_5663  Putative iron-binding membrane protein [KO:K21834]
PFLU_5662  Putative electron transfer flavoprotein alpha subunit [KO:K25960]
PFLU_5661  Putative electron transfer flavoprotein beta subunit [KO:K25961]
PFLU_2317  Putative sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PFLU_5649  soxA; Sarcosine oxidase alpha subunit (EC [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PFLU_2319  soxB; Sarcosine oxidase beta subunit (EC [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PFLU_5651  soxB; Sarcosine oxidase beta subunit (EC [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PFLU_2316  Putative sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PFLU_5648  Putative sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PFLU_5650  soxD; Sarcosine oxidase delta subunit (EC [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PFLU_2318  Putative sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PFLU_2095  Methyltransf_25 domain-containing protein [KO:K18896] [EC:2.1.1.156]
PFLU_3406  Cystathionine beta-lyase (EC [KO:K01697] [EC:4.2.1.22]
PFLU_1035  sdaA; L-serine dehydratase (EC [KO:K01752] [EC:4.3.1.17]
PFLU_4898  L-serine dehydratase (EC [KO:K01752] [EC:4.3.1.17]
PFLU_5679  sdaA; L-serine dehydratase (EC [KO:K01752] [EC:4.3.1.17]
PFLU_5823  ilvA; L-threonine dehydratase (EC (Threonine deaminase) [KO:K01754] [EC:4.3.1.19]
PFLU_2623  D-ser_dehydrat domain-containing protein [KO:K01753] [EC:4.3.1.18]
PFLU_3010  Putative aspartate racemase [KO:K25316] [EC:5.1.1.10]
PFLU_0035  trpA; Tryptophan synthase alpha chain (EC [KO:K01695] [EC:4.2.1.20]
PFLU_0036  trpB; Tryptophan synthase beta chain (EC [KO:K01696] [EC:4.2.1.20]
PFLU_2198  Diaminobutyrate--2-oxoglutarate transaminase (EC (DABA aminotransferase) [KO:K00836] [EC:2.6.1.76]
PFLU_4378  Diaminobutyrate--2-oxoglutarate aminotransferase (EC [KO:K00836] [EC:2.6.1.76]
PFLU_3217  Putative diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pfs00010  Glycolysis / Gluconeogenesis
pfs00020  Citrate cycle (TCA cycle)
pfs00230  Purine metabolism
pfs00250  Alanine, aspartate and glutamate metabolism
pfs00270  Cysteine and methionine metabolism
pfs00290  Valine, leucine and isoleucine biosynthesis
pfs00300  Lysine biosynthesis
pfs00330  Arginine and proline metabolism
pfs00460  Cyanoamino acid metabolism
pfs00470  D-Amino acid metabolism
pfs00564  Glycerophospholipid metabolism
pfs00620  Pyruvate metabolism
pfs00630  Glyoxylate and dicarboxylate metabolism
pfs00640  Propanoate metabolism
pfs00680  Methane metabolism
pfs00860  Porphyrin metabolism
pfs00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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