Entry Name Gastric acid secretion - Peromyscus leucopus (white-footed mouse)
Description Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680674 Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
114682227 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114683830 Cckbr; LOW QUALITY PROTEIN: gastrin/cholecystokinin type B receptor [KO:K04195 ]
114685023 Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131 ]
114689941 Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
114690689 Kcnj10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
114690974 Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
114691978 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
114693172 Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
114693978 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515 ] [EC:2.7.11.17 ]
114694160 Kcnq1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
114694716 Cftr; LOW QUALITY PROTEIN: cystic fibrosis transmembrane conductance regulator [KO:K05031 ] [EC:5.6.1.6 ]
114698218 Kcnk2; potassium channel subfamily K member 2 isoform X1 [KO:K04913 ]
114698420 Kcne2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
114699759 Kcnj1; ATP-sensitive inward rectifier potassium channel 1 isoform X2 [KO:K04995 ]
114699988 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
114700207 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114700363 Kcnj15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
114703666 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
114703672 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
114705004 Kcnk10; potassium channel subfamily K member 10 isoform X1 [KO:K04920 ]
114707396 Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
114708228 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
114708260 Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
114708393 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
114710969 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Schubert ML, Peura DA
Title Control of gastric acid secretion in health and disease.
Journal Reference Authors Urushidani T, Forte JG
Title Signal transduction and activation of acid secretion in the parietal cell.
Journal Reference Authors Yao X, Forte JG
Title Cell biology of acid secretion by the parietal cell.
Journal Reference Authors Heitzmann D, Warth R
Title No potassium, no acid: K+ channels and gastric acid secretion.
Journal Reference Authors Kopic S, Murek M, Geibel JP
Title Revisiting the parietal cell.
Journal Reference Authors Schubert ML
Title Gastric secretion.
Journal Reference Authors Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal J Physiol Pharmacol 56:507-30 (2005)
Reference Authors Forte JG, Zhu L
Title Apical recycling of the gastric parietal cell H,K-ATPase.
Journal Reference Authors Szaszak M, Christian F, Rosenthal W, Klussmann E
Title Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal Reference Authors Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal Related KO pathway
