KEGG   PATHWAY: pleu04020
Entry
pleu04020                   Pathway                                
Name
Calcium signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pleu04020  Calcium signaling pathway
pleu04020

Other DBs
GO: 0019722
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114686117  Slc8a1; LOW QUALITY PROTEIN: sodium/calcium exchanger 1 [KO:K05849]
114681419  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
114698733  Slc8a3; LOW QUALITY PROTEIN: sodium/calcium exchanger 3 [KO:K05849]
114689622  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
114698097  Atp2b4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
114706243  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
114701199  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
114702318  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
114683623  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
114685023  Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
114683079  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
114697493  muscarinic acetylcholine receptor M5-like [KO:K04133]
114696483  Adora2a; adenosine receptor A2a [KO:K04266]
114682956  Adora2b; adenosine receptor A2b [KO:K04267]
114697069  Adrb1; beta-1 adrenergic receptor [KO:K04141]
114707380  Adrb2; beta-2 adrenergic receptor [KO:K04142]
114686807  Adrb3; beta-3 adrenergic receptor [KO:K04143]
114689474  Drd1; D(1A) dopamine receptor [KO:K04144]
114702090  Drd5; D(1B) dopamine receptor [KO:K05840]
114689472  Hrh2; histamine H2 receptor [KO:K04150]
114707407  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
114680899  5-hydroxytryptamine receptor 5B-like [KO:K04161]
114689772  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
114697181  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
114702429  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
114682025  neuroendocrine secretory protein 55-like [KO:K04632]
114682029  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
114682360  Gnal; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
114693962  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114696121  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114697107  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114708701  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114708501  Adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
114697724  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114710615  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114710697  Pln; cardiac phospholamban [KO:K05852]
114690369  Sln; sarcolipin [KO:K22642]
114698516  Mrln; myoregulin [KO:K22643]
114701377  C6H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
114707042  Smim6; small integral membrane protein 6 [KO:K26468]
114686672  Atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
114704560  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
114706333  Atp2a3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
114694084  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
114684625  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
114706639  Stim1; stromal interaction molecule 1 isoform X3 [KO:K16059]
114690925  Stim2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
114704549  Orai1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
114710320  Orai2; protein orai-2 [KO:K16057]
114704390  Orai3; protein orai-3 [KO:K16058]
114700762  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X8 [KO:K04850]
114686204  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114701281  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114683299  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114684157  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
114692733  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
114692885  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
114681218  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
114694287  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X3 [KO:K04856]
114695505  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
114692778  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
114695532  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114695020  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114707044  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
114684718  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
114686569  Grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
114684093  Grin3b; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
114706354  P2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
114682911  P2rx2; P2X purinoceptor 2 isoform X2 [KO:K05216]
114710135  P2rx3; P2X purinoceptor 3 [KO:K05217]
114704556  P2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
114706341  P2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
114688144  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
114704557  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
114684981  Ryr1; ryanodine receptor 1 isoform X5 [KO:K04961]
114685054  Ryr2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
119087871  ryanodine receptor 3-like isoform X1 [KO:K04962]
119087872  LOW QUALITY PROTEIN: ryanodine receptor 3-like [KO:K04962]
114683087  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
114692538  triadin-like [KO:K23449]
114692539  triadin-like [KO:K23449]
114690695  Casq1; calsequestrin-1 [KO:K23468]
114698575  Casq2; calsequestrin-2 [KO:K23445]
114707589  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X18 [KO:K00476] [EC:1.14.11.16]
114704889  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
114698790  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
114691013  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
114707299  Adra1a; LOW QUALITY PROTEIN: alpha-1A adrenergic receptor [KO:K04135]
114702710  alpha-1A adrenergic receptor [KO:K04135]
114689830  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
114699520  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
114686251  Agtr1; type-1 angiotensin II receptor [KO:K04166]
114701075  type-1A angiotensin II receptor [KO:K04166]
114709202  Ednra; endothelin-1 receptor [KO:K04197]
114690208  Ednrb; endothelin receptor type B [KO:K04198]
114694648  F2r; proteinase-activated receptor 1 [KO:K03914]
114702904  proteinase-activated receptor 1-like [KO:K03914]
114686464  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
114682737  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
114705722  Grpr; gastrin-releasing peptide receptor [KO:K04169]
114689626  Hrh1; histamine H1 receptor [KO:K04149]
114684055  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
114697869  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
114698802  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
114709320  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
114704200  Ntsr1; LOW QUALITY PROTEIN: neurotensin receptor type 1 [KO:K04211]
114689586  Oxtr; oxytocin receptor [KO:K04229]
114693288  Avpr1a; vasopressin V1a receptor [KO:K04226]
114698040  Avpr1b; vasopressin V1b receptor [KO:K04227]
114708702  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
114705956  Ptafr; platelet-activating factor receptor [KO:K04279]
114688217  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
114707610  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
114699837  Ptgfr; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
114701888  Bdkrb1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
114701887  Bdkrb2; B2 bradykinin receptor [KO:K03916]
114694432  Tacr1; substance-P receptor [KO:K04222]
114704727  Tacr2; substance-K receptor [KO:K04223]
114683100  Tacr3; neuromedin-K receptor [KO:K04224]
114688368  Tbxa2r; LOW QUALITY PROTEIN: thromboxane A2 receptor [KO:K04264]
114692272  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
114700964  thyrotropin-releasing hormone receptor-like [KO:K04282]
114690908  Cckar; LOW QUALITY PROTEIN: cholecystokinin receptor type A [KO:K04194]
114683830  Cckbr; LOW QUALITY PROTEIN: gastrin/cholecystokinin type B receptor [KO:K04195]
114687227  gastrin/cholecystokinin type B receptor [KO:K04195]
114696964  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
114696911  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
114688160  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
114696913  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
114688171  Gna15; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114680857  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
114682214  Pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114694276  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114700491  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114708007  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114708354  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114707170  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
114683479  Fgf18; fibroblast growth factor 18 [KO:K04358]
114684105  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
114704240  Fgf10; fibroblast growth factor 10 [KO:K04358]
114704897  Fgf16; fibroblast growth factor 16 [KO:K04358]
114698782  Fgf17; fibroblast growth factor 17 [KO:K04358]
114693842  Fgf9; fibroblast growth factor 9 [KO:K04358]
114708136  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
114701407  Fgf6; fibroblast growth factor 6 [KO:K04358]
114695166  Fgf20; fibroblast growth factor 20 [KO:K04358]
114695227  Fgf3; fibroblast growth factor 3 [KO:K04358]
114695229  Fgf4; fibroblast growth factor 4 [KO:K04358]
114695719  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
114709068  Fgf7; fibroblast growth factor 7 [KO:K04358]
114695237  Fgf19; fibroblast growth factor 19 [KO:K22603]
114684727  Fgf21; fibroblast growth factor 21 [KO:K22429]
114701473  Fgf23; fibroblast growth factor 23 [KO:K22428]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114680692  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
114683909  Vegfc; vascular endothelial growth factor C [KO:K05449]
114705711  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114698577  Ngf; beta-nerve growth factor [KO:K02582]
114687327  Hgf; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
114705223  Mst1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
114697350  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114706940  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114681754  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114693631  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114683759  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114707365  Pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114681341  Fgfr1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
114692385  Fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
114694056  Fgfr3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114689359  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114699134  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114681497  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114683507  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114683361  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114688557  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114699869  Ntrk3; NT-3 growth factor receptor isoform X6 [KO:K05101] [EC:2.7.10.1]
114694721  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114705264  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
114689662  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114682505  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
114702255  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
114709282  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4 [KO:K05857] [EC:3.1.4.11]
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114702463  Plce1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
114695062  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114687856  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114709225  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114699633  Tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
114694507  Tpcn2; two pore calcium channel protein 2 [KO:K14077]
114683161  Mcoln1; mucolipin-1 isoform X2 [KO:K04992]
114698247  Mcoln2; mucolipin-2 [KO:K04993]
114698276  Mcoln3; mucolipin-3 isoform X1 [KO:K04994]
114684677  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
114707026  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
114708890  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114681917  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114691928  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
114700220  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114705743  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114710781  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
114711016  ADP/ATP translocase 2-like [KO:K05863]
114705416  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
114701179  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
114694445  ADP/ATP translocase 2-like [KO:K05863]
114709626  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114708193  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
114692708  Tnnc2; troponin C, skeletal muscle [KO:K12042]
114691640  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
114681418  Calm3; calmodulin-3 [KO:K02183]
114705020  Calm1; calmodulin-1 [KO:K02183]
114708260  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
114708768  calmodulin-4-like [KO:K02183]
114708779  Calml3; calmodulin-like protein 3 [KO:K02183]
114709209  Calm2; calmodulin-2 [KO:K02183]
114704378  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
114693674  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
114708631  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
114695797  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
114709953  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
114704843  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114705574  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
114702188  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114709967  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
114689600  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
114702392  Camk1g; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
114682227  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
114700207  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114693978  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515] [EC:2.7.11.17]
114707396  Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
114691636  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698806  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705332  Tfeb; transcription factor EB isoform X1 [KO:K15590]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114684433  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114708726  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114699651  Nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
114691518  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
114700088  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114689696  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
114696597  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
114703726  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
114707316  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
114690633  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
114681117  LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
114681535  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
114692309  inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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PMID:11698232
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
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Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
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Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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Yakel JL.
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pleu04010  MAPK signaling pathway
pleu04070  Phosphatidylinositol signaling system
pleu04210  Apoptosis
pleu04720  Long-term potentiation
pleu04730  Long-term depression
KO pathway
ko04020   
LinkDB

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