KEGG   PATHWAY: pret00260
Entry
pret00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Poecilia reticulata (guppy)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pret00260  Glycine, serine and threonine metabolism
pret00260

Module
pret_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pret00260]
pret_M00047  Creatine pathway [PATH:pret00260]
pret_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pret00260]
pret_M00555  Betaine biosynthesis, choline => betaine [PATH:pret00260]
pret_M00621  Glycine cleavage system [PATH:pret00260]
pret_M00974  Betaine metabolism, animals, betaine => glycine [PATH:pret00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Poecilia reticulata (guppy) [GN:pret]
Gene
103457629  [KO:K15789] [EC:1.1.1.103]
103458637  [KO:K15789] [EC:1.1.1.103]
103458708  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
103459803  [KO:K01697] [EC:4.2.1.22]
103460681  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103461416  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103462051  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
103462489  gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
103463348  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
103463490  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
103463960  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103464136  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103464394  shmt2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
103464428  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
103464499  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
103465642  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
103465753  [KO:K01834] [EC:5.4.2.11]
103465823  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
103466594  [KO:K00049] [EC:1.1.1.79 1.1.1.81]
103468004  [KO:K00643] [EC:2.3.1.37]
103468014  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
103468040  [KO:K00600] [EC:2.1.2.1]
103468150  [KO:K00276] [EC:1.4.3.21]
103468519  [KO:K00639] [EC:2.3.1.29]
103468538  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
103469944  gldc; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
103469969  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
103470080  [KO:K00544] [EC:2.1.1.5]
103470081  [KO:K00544] [EC:2.1.1.5]
103470317  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
103470553  sds; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103471304  grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
103473305  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
103473309  [KO:K00544] [EC:2.1.1.5]
103473527  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
103473575  [KO:K01834] [EC:5.4.2.11]
103473627  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
103473873  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
103474005  [KO:K00274] [EC:1.4.3.4]
103474319  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
103474492  [KO:K01697] [EC:4.2.1.22]
103474559  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
103476893  pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
103477344  [KO:K01754] [EC:4.3.1.19]
103478854  [KO:K20498] [EC:4.3.1.18]
103479647  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103481316  [KO:K00643] [EC:2.3.1.37]
103481637  maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
103481824  [KO:K01620] [EC:4.1.2.48]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pret00010  Glycolysis / Gluconeogenesis
pret00020  Citrate cycle (TCA cycle)
pret00230  Purine metabolism
pret00250  Alanine, aspartate and glutamate metabolism
pret00270  Cysteine and methionine metabolism
pret00290  Valine, leucine and isoleucine biosynthesis
pret00330  Arginine and proline metabolism
pret00470  D-Amino acid metabolism
pret00564  Glycerophospholipid metabolism
pret00600  Sphingolipid metabolism
pret00620  Pyruvate metabolism
pret00630  Glyoxylate and dicarboxylate metabolism
pret00640  Propanoate metabolism
pret00860  Porphyrin metabolism
pret00920  Sulfur metabolism
KO pathway
ko00260   

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