KEGG   PATHWAY: ptao04141
Entry
ptao04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Phyllopteryx taeniolatus (common seadragon)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ptao04141  Protein processing in endoplasmic reticulum
ptao04141

Other DBs
GO: 0030433 0034976
Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133465215  sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
133465230  [KO:K10575] [EC:2.3.2.23]
133465293  si:ch211-282j22.3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
133465584  hspbp1; hsp70-binding protein 1 isoform X1 [KO:K09562]
133465730  dnajb1a; dnaJ homolog subfamily B member 1a [KO:K09507]
133465743  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
133465798  atf4b; activating transcription factor 4b [KO:K04374]
133465885  prkcsh; glucosidase 2 subunit beta [KO:K08288]
133466044  [KO:K10839]
133466053  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
133466321  [KO:K02159]
133466732  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
133466867  hyou1; hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
133466877  sar1b; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
133467195  skp1; S-phase kinase-associated protein 1 [KO:K03094]
133467244  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
133467255  sec24a; protein transport protein Sec24A isoform X1 [KO:K14007]
133467576  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
133467671  [KO:K09542]
133467900  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133467944  ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
133467963  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
133467992  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
133468030  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
133468057  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
133468079  pdia6; protein disulfide-isomerase A6 isoform X1 [KO:K09584] [EC:5.3.4.1]
133468187  sec63; translocation protein SEC63 homolog [KO:K09540]
133468234  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
133468373  dnajc5ga; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma a isoform X1 [KO:K09525]
133468522  sel1l; protein sel-1 homolog 1 isoform X1 [KO:K14026]
133468643  ubxn2a; UBX domain-containing protein 2A [KO:K24349]
133468728  [KO:K03283]
133468941  nploc4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
133469021  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
133469040  dnajb12b; dnaJ homolog subfamily B member 12b [KO:K09518]
133469052  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133469223  sec31b; protein transport protein Sec31A isoform X1 [KO:K14005]
133469263  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
133469614  [KO:K06689] [EC:2.3.2.23]
133469965  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
133469981  selenos; selenoprotein S isoform X1 [KO:K14025]
133470016  zgc:153993; apoptosis regulator BAX [KO:K02159]
133470090  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
133470205  txndc5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
133470271  [KO:K03347]
133470292  tram1; translocating chain-associated membrane protein 1 [KO:K14010]
133470319  [KO:K10661] [EC:2.3.2.27]
133470325  mbtps2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
133470354  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
133470630  rnf5; E3 ubiquitin-protein ligase RNF5 isoform X1 [KO:K10666] [EC:2.3.2.27]
133470707  ube2g2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
133470826  stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
133470874  ubqln4; ubiquilin-4 [KO:K04523]
133470962  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
133470966  [KO:K08056] [EC:5.3.4.1]
133471318  ssr2; translocon-associated protein subunit beta [KO:K13250]
133471384  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
133471757  [KO:K13999]
133472347  dnajc3b; dnaJ homolog subfamily C member 3b isoform X1 [KO:K09523]
133472417  sec24d; protein transport protein Sec24D [KO:K14007]
133472538  [KO:K01367] [EC:3.4.22.52]
133472597  [KO:K01367] [EC:3.4.22.52]
133472629  plaa; phospholipase A-2-activating protein isoform X1 [KO:K14018]
133472712  capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
133472802  ostc; oligosaccharyltransferase complex subunit ostc [KO:K26501]
133473202  [KO:K01367] [EC:3.4.22.52]
133473507  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
133473520  [KO:K09525]
133473610  dnaja2a; dnaJ homolog subfamily A member 2a [KO:K09503]
133474268  [KO:K10636] [EC:2.3.2.36]
133474596  [KO:K03173] [EC:2.3.2.27]
133474734  [KO:K10575] [EC:2.3.2.23]
133475146  ufd1l; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
133475368  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
133475545  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
133475731  si:dkey-13n15.2; protein transport protein Sec24C [KO:K14007]
133475795  xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
133476229  [KO:K19478]
133476310  dnajb1b; dnaJ homolog subfamily B member 1b [KO:K09507]
133476405  sec23b; protein transport protein Sec23B [KO:K14006]
133476520  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
133476567  dnajc5aa; dnaJ (Hsp40) homolog, subfamily C, member 5aa [KO:K09525]
133476684  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
133476952  [KO:K03853] [EC:3.4.22.53]
133476967  ero1b; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
133477049  wfs1a; wolframin isoform X1 [KO:K14020]
133477200  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
133477231  mogs; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
133477242  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
133477397  ssr4; translocon-associated protein subunit delta [KO:K04571]
133477491  dnaja1; dnaJ homolog subfamily A member 1 [KO:K09502]
133477659  mbtps1; membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
133477724  hsp90b1; endoplasmin [KO:K09487]
133477971  [KO:K10100]
133478028  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
133478127  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
133478322  dnaja2b; dnaJ homolog subfamily A member 2b [KO:K09503]
133478489  tmem258; transmembrane protein 258 [KO:K26502]
133478532  svip; small VCP/p97-interacting protein [KO:K14014]
133479075  derl1; derlin-1 [KO:K11519]
133479267  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
133479291  hspb6; heat shock protein beta-6 [KO:K09542]
133479340  preb; prolactin regulatory element-binding protein [KO:K14003]
133479416  krtcap2; keratinocyte-associated protein 2 isoform X1 [KO:K28202]
133479543  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133479551  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
133480195  [KO:K01230] [EC:3.2.1.113]
133480375  ubxn6; UBX domain-containing protein 6 [KO:K14011]
133480467  edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
133480723  atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
133480999  [KO:K10839]
133481000  [KO:K08057]
133481022  calr; calreticulin [KO:K08057]
133481947  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
133482050  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
133482274  ssr3; translocon-associated protein subunit gamma [KO:K13251]
133483025  sec13; protein SEC13 homolog [KO:K14004]
133483060  yod1; ubiquitin thioesterase OTU1 isoform X1 [KO:K13719] [EC:3.1.2.-]
133483106  [KO:K13249]
133483144  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
133483279  sec61a1a; protein transport protein Sec61 subunit alpha-like 1 isoform X1 [KO:K10956]
133483435  cryaa; alpha-crystallin A chain [KO:K09541]
133483462  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
133483668  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
133483743  [KO:K10956]
133483760  os9; protein OS-9 isoform X1 [KO:K10088]
133483786  rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
133483857  fbxo2; F-box only protein 2 isoform X1 [KO:K10099]
133484120  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
133484349  syvn1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
133484364  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133484483  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
133484727  magt1; magnesium transporter protein 1 [KO:K19478]
133484749  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
133484826  bcap31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
133484830  sec24b; protein transport protein Sec24B isoform X1 [KO:K14007]
133484862  [KO:K03283]
133484909  canx; calnexin [KO:K08054]
133484912  [KO:K06689] [EC:2.3.2.23]
133484955  ubxn1; UBX domain-containing protein 1 isoform X1 [KO:K24348]
133485234  ganabb; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
133485277  wfs1b; wolframin isoform X1 [KO:K14020]
133485281  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
133485523  nsfl1c; NSFL1 cofactor p47 [KO:K14012]
133485541  sar1ab; secretion associated, Ras related GTPase 1Ab [KO:K07953] [EC:3.6.5.-]
133485556  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
133485584  dnajb12a; dnaJ homolog subfamily B member 12a [KO:K09518]
133485601  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133485734  rrbp1a; ribosome-binding protein 1a isoform X1 [KO:K14000]
133485739  [KO:K01367] [EC:3.4.22.52]
133485740  [KO:K03853] [EC:3.4.22.53]
133485741  [KO:K03853] [EC:3.4.22.53]
133485902  erlec1; endoplasmic reticulum lectin 1 [KO:K14008]
133486239  [KO:K06689] [EC:2.3.2.23]
133486392  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
133486472  nfe2l2a; nuclear factor erythroid 2-related factor 2a isoform X1 [KO:K05638]
133486646  uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
133486648  dnajc3a; dnaJ homolog subfamily C member 3a isoform X1 [KO:K09523]
133486907  ubxn4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
133486977  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
133487015  dnajb2; dnaJ homolog subfamily B member 2 [KO:K09508]
133487080  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
133487466  uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
133487531  hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
133487560  [KO:K14006]
133487850  atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
133487854  zgc:113278; translocating chain-associated membrane protein 1-like 1-like [KO:K14010]
133487881  zgc:136872; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
133488165  [KO:K06689] [EC:2.3.2.23]
133488278  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
133488338  dnajc5gb; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma b isoform X1 [KO:K09525]
133488470  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
133488539  [KO:K10661] [EC:2.3.2.27]
133488564  sec62; translocation protein SEC62 [KO:K12275]
133488741  dnajc1; LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 1 [KO:K09521]
133488753  [KO:K09525]
133488936  dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
133488973  calr3b; calreticulin 3b [KO:K08057]
133489153  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
133489860  man1b1a; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741]
133490160  rnf185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
133490174  rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
133490181  hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
133490221  lman1; protein ERGIC-53 [KO:K10080]
133490230  [KO:K03173] [EC:2.3.2.27]
133490257  derl2; derlin-2 [KO:K13989]
133490304  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
133490325  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ptao00510  N-Glycan biosynthesis
ptao03050  Proteasome
ptao03060  Protein export
ptao04210  Apoptosis
KO pathway
ko04141   

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