KEGG PATHWAY: rno04330

KEGG

PATHWAY: rno04330

Entry

rno04330                    Pathway

Name

Notch signaling pathway - Rattus norvegicus (rat)

Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Class

Environmental Information Processing; Signal transduction

Pathway map

Notch signaling pathway

Other DBs

GO:

Organism

Rattus norvegicus (rat) [GN:rno]

Gene

Dll3; delta-like protein 3 precursor [KO:K06051]

Dll4; delta-like protein 4 precursor [KO:K06051]

Dll1; delta-like protein 1 precursor [KO:K06051]

Jag1; protein jagged-1 precursor [KO:K06052]

Jag2; protein jagged-2 isoform 2 [KO:K21635]

Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]

Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor [KO:K05948] [EC:2.4.1.222]

Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]

Notch1; neurogenic locus notch homolog protein 1 precursor [KO:K02599]

Notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]

Notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995]

Notch4; neurogenic locus notch homolog protein 4 precursor [KO:K20996]

Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]

Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053]

Hes1; transcription factor HES-1 [KO:K06054]

Hes5; transcription factor HES-5 [KO:K06055]

Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]

Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]

Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]

Ptcra; pre T-cell antigen receptor alpha precursor [KO:K06056]

Nrarp; notch-regulated ankyrin repeat-containing protein [KO:K26480]

Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]

Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]

Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]

Numbl; numb-like protein isoform 2 [KO:K06057]

Numb; protein numb homolog isoform 2 [KO:K06057]

Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]

Dtx2; probable E3 ubiquitin-protein ligase DTX2 [KO:K06058] [EC:2.3.2.27]

Dtx1; E3 ubiquitin-protein ligase DTX1 isoform X1 [KO:K06058] [EC:2.3.2.27]

Dtx3; probable E3 ubiquitin-protein ligase DTX3 [KO:K06058] [EC:2.3.2.27]

Dtx3l; E3 ubiquitin-protein ligase DTX3L [KO:K06058] [EC:2.3.2.27]

Dtx4; E3 ubiquitin-protein ligase DTX4 isoform 1 [KO:K06058] [EC:2.3.2.27]

Adam17; disintegrin and metalloproteinase domain-containing protein 17 precursor [KO:K06059] [EC:3.4.24.86]

Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]

Psen2; presenilin-2 [KO:K04522] [EC:3.4.23.-]

Psenen; gamma-secretase subunit PEN-2 [KO:K06170]

Ncstn; nicastrin precursor [KO:K06171]

Aph1a; gamma-secretase subunit APH-1A [KO:K06172]

Aph1b; gamma-secretase subunit APH-1B [KO:K06172]

Aph1bl2; similar to anterior pharynx defective 1b homolog [KO:K06172]

Maml2; mastermind-like protein 2 isoform X1 [KO:K06061]

Maml3; mastermind-like protein 3 [KO:K06061]

Maml1; mastermind-like protein 1 [KO:K06061]

Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]

Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]

Kat2a; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]

Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]

Snw1; SNW domain-containing protein 1 [KO:K06063]

Ctbp1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]

Ctbp2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]

Tle7; transducin-like enhancer protein 7 isoform X2 [KO:K04497]

Tle4; transducin-like enhancer protein 4 isoform 2 [KO:K04497]

Tle2; transducin-like enhancer protein 2 [KO:K04497]

Tle6; transducin-like enhancer protein 6 isoform X1 [KO:K04497]

Tle1; transducin-like enhancer protein 1 [KO:K04497]

Tle3; transducin-like enhancer protein 3 [KO:K04497]

Ncor2; nuclear receptor corepressor 2 [KO:K06065]

Cir1; corepressor interacting with RBPJ 1 [KO:K06066]

Spen; msx2-interacting protein [KO:K25100]

Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]

Hdac1l; histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]

Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]

Atxn1l; ataxin-1-like [KO:K23616]

Atxn1; ataxin-1 [KO:K23616]

Compound

Notch intracellular domain

Reference

Authors

Hansson EM, Lendahl U, Chapman G.

Title

Notch signaling in development and disease.

Journal

Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011

Reference

Authors

Callahan R, Egan SE.

Title

Notch signaling in mammary development and oncogenesis.

Journal

J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81

Reference

Authors

Zweidler-McKay PA, Pear WS.

Title

Notch and T cell malignancy.

Journal

Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012

Reference

Authors

Wu L, Griffin JD.

Title

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.

Journal

Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014

Reference

Authors

Tsukumo S, Yasutomo K.

Title

Notch governing mature T cell differentiation.

Journal

J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109

Reference

Authors

Haltiwanger RS.

Title

Regulation of signal transduction pathways in development by glycosylation.

Journal

Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8

Reference

Authors

Koo EH, Kopan R.

Title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Journal

Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065

Reference

Authors

Okano H, Imai T, Okabe M.

Title

Musashi: a translational regulator of cell fate.

Journal

J Cell Sci 115:1355-9 (2002)

Reference

Authors

Haltiwanger RS, Stanley P.

Title

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.

Journal

Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2

Reference

Authors

Das G, Reynolds-Kenneally J, Mlodzik M.

Title

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.

Journal

Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8

Reference

Authors

Cooper MT, Bray SJ.

Title

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.

Journal

Nature 397:526-30 (1999)
DOI:10.1038/17395

Reference

Authors

Tanigaki K, Kuroda K, Han H, Honjo T.

Title

Regulation of B cell development by Notch/RBP-J signaling.

Journal

Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3

Related
pathway

MAPK signaling pathway

KO pathway

LinkDB

DBGET integrated database retrieval system