KEGG   PATHWAY: rno04010
Entry
rno04010                    Pathway                                
Name
MAPK signaling pathway - Rattus norvegicus (rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04010  MAPK signaling pathway
rno04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360982  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
102546674  [KO:K04381]
102551813  [KO:K04381]
103691134  Flt3lg; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
108348108  Hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
114110  Flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
114111  Vegfc; vascular endothelial growth factor C precursor [KO:K05449]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114493  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114495  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
114509  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114513  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
114856  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114862  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
116457  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
116499  Fgf4; fibroblast growth factor 4 precursor [KO:K04358]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116596  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116600  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform 2 [KO:K04863]
116663  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
116683  Efna5; ephrin-A5 precursor [KO:K05462]
117269  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
140635  Flt3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
140724  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
140725  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
140726  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
140727  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
140728  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
140729  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
140926  Daxx; death domain-associated protein 6 [KO:K02308]
170579  Fgf22; fibroblast growth factor 22 precursor [KO:K04358]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
170582  Fgf19; fibroblast growth factor 19 precursor [KO:K22603]
170583  Fgf23; fibroblast growth factor 23 precursor [KO:K22428]
170633  Fgf3; fibroblast growth factor 3 precursor [KO:K04358]
170668  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170901  Efna3; ephrin-A3 isoform X1 [KO:K05462]
170920  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
171103  Cdc25b; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
171109  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
171337  Rap1b; ras-related protein Rap-1b precursor [KO:K07836]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
171492  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
192213  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform 1 [KO:K04349]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24225  Bdnf; brain-derived neurotrophic factor isoform 3 preproprotein [KO:K04355]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
24446  Hgf; hepatocyte growth factor preproprotein [KO:K05460]
24468  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
24471  Hspb1; heat shock protein beta-1 [KO:K04455]
24472  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
24483  Igf2; insulin-like growth factor II isoform 2 preproprotein [KO:K13769]
24493  Il1a; interleukin-1 alpha [KO:K04383]
24494  Il1b; interleukin-1 beta [KO:K04519]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24516  Jun; transcription factor Jun [KO:K04448]
24518  Jund; transcription factor JunD isoform JunD-FL [KO:K04449]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24592  Nf1; neurofibromin [KO:K08052]
24596  Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
24605  Nras; GTPase NRas [KO:K07828]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
24653  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
24666  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
24667  Ppm1b; protein phosphatase 1B isoform 1 [KO:K04461] [EC:3.1.3.16]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
246781  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24716  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126] [EC:2.7.10.1]
24827  Tgfa; protransforming growth factor alpha preproprotein [KO:K08774]
24835  Tnf; tumor necrosis factor [KO:K03156]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24954  Insr; insulin receptor preproprotein [KO:K04527] [EC:2.7.10.1]
24963  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25054  Ntrk2; BDNF/NT-3 growth factors receptor isoform 1 precursor [KO:K04360] [EC:2.7.10.1]
25112  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25297  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
25387  Arrb1; beta-arrestin-1 [KO:K04439]
25388  Arrb2; beta-arrestin-2 [KO:K04439]
25398  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
25399  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor [KO:K04858]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25443  Fgf10; fibroblast growth factor 10 precursor [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25453  Gdnf; glial cell line-derived neurotrophic factor isoform 1 [KO:K05452]
25466  Il1rap; interleukin-1 receptor accessory protein precursor [KO:K04723]
25482  Mras; ras-related protein M-Ras [KO:K07831]
25525  Pspn; persephin precursor [KO:K25416]
25579  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
25589  Kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
25597  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25663  Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386]
25676  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
25717  Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
25730  Ntf4; neurotrophin-4 precursor [KO:K12457]
257648  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [KO:K04849]
286993  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
287398  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
287942  Crkl; crk-like protein [KO:K04438]
289014  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
291005  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
29183  Areg; amphiregulin preproprotein [KO:K09782]
292763  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
29332  Stmn1; stathmin [KO:K04381]
29348  Fgf7; fibroblast growth factor 7 precursor [KO:K04358]
29349  Fgf8; fibroblast growth factor 8 isoform 1 precursor [KO:K04358]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
293621  Hras; GTPase HRas [KO:K02833]
29368  Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 precursor [KO:K04358]
293694  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform 1 [KO:K04414] [EC:2.7.11.1]
293847  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
293860  Flna; filamin-A [KO:K04437]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
29432  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
29434  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
29467  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
29477  Mapt; microtubule-associated protein tau [KO:K04380]
294924  Mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
29496  Erbb3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
295347  Rap1a; ras-related protein Rap-1A [KO:K04353]
29568  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform a [KO:K04463] [EC:2.7.12.2]
29591  Tgfbr1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
296091  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
296269  Angpt4; angiopoietin-4 precursor [KO:K05467]
29644  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
29658  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
29717  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 [KO:K04854]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
297682  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
299618  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
299626  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
300447  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor [KO:K04405]
300980  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
300992  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 precursor [KO:K04859]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
301363  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [KO:K04407] [EC:2.7.11.1]
302983  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
303200  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
303604  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
303823  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
304530  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
304786  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
306243  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 precursor [KO:K04860]
307403  Csf1r; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
307950  Map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
308106  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform 2 [KO:K04428] [EC:2.7.11.25]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
308463  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
309165  Rela; transcription factor p65 [KO:K04735]
309168  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309452  Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
310533  Rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018]
310643  Efna4; ephrin-A4 precursor [KO:K05462]
310738  Ngf; beta-nerve growth factor precursor [KO:K02582]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311341  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
311406  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
311622  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
311743  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform 1 [KO:K04424] [EC:2.7.11.25]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
312668  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
313022  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
313874  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
314322  Fos; protein c-Fos [KO:K04379]
314384  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
314436  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
315139  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
315220  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
315994  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
317203  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
360457  Vegfd; vascular endothelial growth factor D precursor [KO:K05449]
360640  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
361568  Rras; ras-related protein R-Ras [KO:K07829]
361679  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
361714  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
361715  Rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
362045  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
362572  Artn; artemin precursor [KO:K25415]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
363855  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431] [EC:2.7.12.2]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
365057  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
365355  Rras2; ras-related protein R-Ras2 [KO:K07830]
366492  Epha2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
497961  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
498003  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
498183  Mapkapk5; MAP kinase-activated protein kinase 5 isoform 2 [KO:K04442] [EC:2.7.11.1]
499497  Mef2c; myocyte-specific enhancer factor 2C isoform 1 [KO:K04454]
500526  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
500690  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
501099  Srf; serum response factor [KO:K04378]
501560  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50688  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54234  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
54245  Crk; adapter molecule crk [KO:K04438]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
54251  Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096] [EC:2.7.10.1]
56827  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
58942  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform 2 [KO:K04865]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
59086  Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
59109  Ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
59323  Erbb4; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
59325  Ereg; proepiregulin preproprotein [KO:K09784]
60350  Cd14; monocyte differentiation antigen CD14 precursor [KO:K04391]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60427  Kitlg; kit ligand isoform 1 precursor [KO:K05461]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
60587  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
60661  Max; protein max isoform 1 [KO:K04453]
60662  Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
63995  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
64030  Kit; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64666  Taok2; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
65179  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
65189  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
66018  Pdgfd; platelet-derived growth factor D precursor [KO:K05450]
680121  Haus8l2; heat shock cognate 71 kDa protein-like [KO:K03283]
682930  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
691810  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
691905  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
691907  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
78965  Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
79240  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
79429  Pdgfc; platelet-derived growth factor C precursor [KO:K05450]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81663  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81737  Ntf3; neurotrophin-3 isoform 3 precursor [KO:K04356]
81771  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
81809  Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
81810  Tgfbr2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
84347  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84358  Efna2; ephrin-A2 precursor [KO:K05462]
84423  Nrtn; neurturin precursor [KO:K25414]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
89804  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
89805  Angpt2; angiopoietin-2 precursor [KO:K05466]
89807  Angpt1; angiopoietin-1 precursor [KO:K05465]
89811  Vegfb; vascular endothelial growth factor B precursor [KO:K16858]
94202  Ptprr; receptor-type tyrosine-protein phosphatase R isoform 1 precursor [KO:K04458] [EC:3.1.3.48]
94203  Pgf; placenta growth factor precursor [KO:K16859]
94268  Efna1; ephrin-A1 precursor [KO:K05462]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
rno04070  Phosphatidylinositol signaling system
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04210  Apoptosis
rno04310  Wnt signaling pathway
rno04668  TNF signaling pathway
KO pathway
ko04010   

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