KEGG   PATHWAY: spu00600
Entry
spu00600                    Pathway                                
Name
Sphingolipid metabolism - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Lipid metabolism
Pathway map
spu00600  Sphingolipid metabolism
spu00600

Module
spu_M00066  Lactosylceramide biosynthesis [PATH:spu00600]
spu_M00094  Ceramide biosynthesis [PATH:spu00600]
spu_M00099  Sphingosine biosynthesis [PATH:spu00600]
spu_M00100  Sphingosine degradation [PATH:spu00600]
Other DBs
GO: 0006665
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
579033  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
588779  serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
581818  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
115929647  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
586074  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
592336  ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
582683  ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
115926214  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
579635  acid ceramidase [KO:K12348] [EC:3.5.1.23]
593569  acid ceramidase [KO:K12348] [EC:3.5.1.23]
576884  neutral ceramidase [KO:K12349] [EC:3.5.1.23]
580598  putative neutral ceramidase C [KO:K12349] [EC:3.5.1.23]
594681  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
752343  alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
587766  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
584906  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
590197  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
576943  sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
115920339  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
578923  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
577518  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
115923137  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
586788  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
115923054  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
105444871  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
593404  ceramide kinase [KO:K04715] [EC:2.7.1.138]
115919524  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
576030  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
100893799  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
100890064  uncharacterized protein LOC100890064 [KO:K01080] [EC:3.1.3.4]
105445477  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
582069  sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
580005  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
585643  sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
585628  sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
591961  ceramide glucosyltransferase-B [KO:K00720] [EC:2.4.1.80]
105443151  ceramide glucosyltransferase-B-like [KO:K00720] [EC:2.4.1.80]
594677  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
592425  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
100892921  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
589674  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
575065  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
576438  beta-1,4-galactosyltransferase 5 [KO:K07553] [EC:2.4.1.274]
585175  beta-1,4-galactosyltransferase 6-like isoform X1 [KO:K07553] [EC:2.4.1.274]
100893324  beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
115918527  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
585604  beta-1,4-galactosyltransferase 5 [KO:K07553] [EC:2.4.1.274]
115923678  beta-1,4-galactosyltransferase 5-like [KO:K07553] [EC:2.4.1.274]
105447297  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
589658  beta-1,4-galactosyltransferase 5 [KO:K07553] [EC:2.4.1.274]
592897  beta-1,4-galactosyltransferase 5 [KO:K07553] [EC:2.4.1.274]
576421  beta-1,4-galactosyltransferase 5 isoform X1 [KO:K07553] [EC:2.4.1.274]
587517  uncharacterized protein LOC587517 [KO:K07553] [EC:2.4.1.274]
105437633  beta-1,4-galactosyltransferase 5-like [KO:K07553] [EC:2.4.1.274]
115925825  beta-1,4-galactosyltransferase 5-like [KO:K07553] [EC:2.4.1.274]
586027  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
755711  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
588598  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
105439145  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
583786  uncharacterized protein LOC583786 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
587532  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
115925974  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
584869  galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
584891  galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
577607  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
115917897  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
100889492  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
100890023  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
578919  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
100892439  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
753898  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
100892774  galactose-3-O-sulfotransferase 2 [KO:K01019] [EC:2.8.2.11]
115919501  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
100894122  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115920988  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115921129  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
100889799  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115918280  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
105446322  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115925158  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
577909  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
754624  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
115918065  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115927998  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
752559  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
115927456  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
105445666  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
585435  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
115930024  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
575857  galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
583591  arylsulfatase A isoform X2 [KO:K01134] [EC:3.1.6.8]
592372  arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
593966  arylsulfatase A [KO:K01134] [EC:3.1.6.8]
583611  arylsulfatase A isoform X2 [KO:K01134] [EC:3.1.6.8]
574839  arylsulfatase A [KO:K01134] [EC:3.1.6.8]
575079  arylsulfatase [KO:K01134] [EC:3.1.6.8]
582391  arylsulfatase [KO:K01134] [EC:3.1.6.8]
373270  ARS; arylsulfatase precursor [KO:K01134] [EC:3.1.6.8]
115926687  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
578528  arylsulfatase [KO:K01134] [EC:3.1.6.8]
575336  LOW QUALITY PROTEIN: arylsulfatase [KO:K01134] [EC:3.1.6.8]
585449  sialidase-1 [KO:K01186] [EC:3.2.1.18]
100890176  sialidase-1 [KO:K01186] [EC:3.2.1.18]
105446099  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
100890017  sialidase-1 [KO:K01186] [EC:3.2.1.18]
115922781  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
100890097  sialidase-1 [KO:K01186] [EC:3.2.1.18]
583431  sialidase-3 [KO:K12357] [EC:3.2.1.18]
100890472  sialidase-4 [KO:K12357] [EC:3.2.1.18]
115924908  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
764416  sialidase-3 [KO:K12357] [EC:3.2.1.18]
755390  sialidase-3 [KO:K12357] [EC:3.2.1.18]
594823  beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
591308  ganglioside GM2 activator [KO:K12383]
764009  uncharacterized protein LOC764009 [KO:K12383]
581297  prosaposin [KO:K12382]
754171  prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
spu00260  Glycine, serine and threonine metabolism
spu00601  Glycosphingolipid biosynthesis - lacto and neolacto series
spu00603  Glycosphingolipid biosynthesis - globo and isoglobo series
spu00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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