KEGG   PATHWAY: sre00510
Entry
sre00510                    Pathway                                
Name
N-Glycan biosynthesis - Salpingoeca rosetta
Description
N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119].
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
sre00510  N-Glycan biosynthesis
sre00510

Module
sre_M00072  N-glycosylation by oligosaccharyltransferase [PATH:sre00510]
sre_M00073  N-glycan precursor trimming [PATH:sre00510]
Other DBs
GO: 0006487
Organism
Salpingoeca rosetta [GN:sre]
Gene
PTSG_00084  [KO:K12666]
PTSG_00299  [KO:K00726] [EC:2.4.1.101]
PTSG_00782  [KO:K00717] [EC:2.4.1.68]
PTSG_01101  [KO:K03844] [EC:2.4.1.131]
PTSG_01106  [KO:K03845] [EC:2.4.1.258]
PTSG_01395  [KO:K01228] [EC:3.2.1.106]
PTSG_01636  [KO:K00721] [EC:2.4.1.83]
PTSG_01891  [KO:K23741]
PTSG_02232  [KO:K13748] [EC:2.4.1.201 2.4.1.145]
PTSG_02588  [KO:K07432] [EC:2.4.1.141]
PTSG_03147  [KO:K01231] [EC:3.2.1.114]
PTSG_03225  [KO:K03846] [EC:2.4.1.259 2.4.1.261]
PTSG_03244  [KO:K03849] [EC:2.4.1.265]
PTSG_04838  [KO:K00736] [EC:2.4.1.143]
PTSG_05076  [KO:K19478]
PTSG_06019  [KO:K01230] [EC:3.2.1.113]
PTSG_06075  [KO:K07151] [EC:2.4.99.18]
PTSG_06091  [KO:K26502]
PTSG_06230  [KO:K03848] [EC:2.4.1.267]
PTSG_06745  [KO:K07441] [EC:2.4.1.141]
PTSG_06945  [KO:K12670]
PTSG_07075  [KO:K01231] [EC:3.2.1.114]
PTSG_07164  [KO:K03843] [EC:2.4.1.132 2.4.1.257]
PTSG_08009  [KO:K01001] [EC:2.7.8.15]
PTSG_08028  [KO:K12345] [EC:1.3.1.22 1.3.1.94]
PTSG_08042  [KO:K07151] [EC:2.4.99.18]
PTSG_08664  [KO:K00736] [EC:2.4.1.143]
PTSG_09670  [KO:K00902] [EC:2.7.1.108]
PTSG_09775  [KO:K12668]
PTSG_09901  [KO:K00736] [EC:2.4.1.143]
PTSG_09995  [KO:K26501]
PTSG_11360  [KO:K05546] [EC:3.2.1.207]
PTSG_11395  [KO:K03847] [EC:2.4.1.260]
PTSG_11582  [KO:K01231] [EC:3.2.1.114]
PTSG_12270  [KO:K00729] [EC:2.4.1.117]
PTSG_12688  [KO:K28202]
PTSG_12858  [KO:K03842] [EC:2.4.1.142]
PTSG_13096  [KO:K12667]
Compound
C00096  GDP-mannose
C00110  Dolichyl phosphate
C00381  Dolichol
C00621  Dolichyl diphosphate
C01246  Dolichyl beta-D-glucosyl phosphate
C03021  Protein asparagine
C03862  Dolichyl phosphate D-mannose
C06081  Polyprenol
C22974  ditrans,polycis-Polyprenal
C22975  Dolichal
G00001  N-Acetyl-D-glucosaminyldiphosphodolichol
G00002  N,N'-Chitobiosyldiphosphodolichol
G00003  
G00004  
G00005  
G00006  
G00007  
G00008  
G00009  
G00010  
G00011  
G00012  
G00013  
G00014  
G00015  
G00016  Core fucose
G00017  
G00018  DS 3
G00019  
G00020  
G00021  
G00022  
G00171  
G10526  
G10595  
G10596  
G10597  
G10598  
G10599  
G10694  
Reference
PMID:9111134
  Authors
Schutzbach JS.
  Title
The role of the lipid matrix in the biosynthesis of dolichyl-linked oligosaccharides.
  Journal
Glycoconj J 14:175-82 (1997)
DOI:10.1023/A:1018533620002
Reference
  Authors
Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P.
  Title
Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate.
  Journal
Mol Biol Evol 19:1451-63 (2002)
DOI:10.1093/oxfordjournals.molbev.a004208
Reference
  Authors
Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschutter A, von Figura K, Lehle L, Korner C.
  Title
A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 278:22498-505 (2003)
DOI:10.1074/jbc.M302850200
Reference
  Authors
Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N.
  Title
The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum.
  Journal
J Biol Chem 276:21828-40 (2001)
DOI:10.1074/jbc.M010896200
Reference
  Authors
Frank CG, Aebi M.
  Title
ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis.
  Journal
Glycobiology 15:1156-63 (2005)
DOI:10.1093/glycob/cwj002
Reference
  Authors
O'Reilly MK, Zhang G, Imperiali B.
  Title
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.
  Journal
Biochemistry 45:9593-603 (2006)
DOI:10.1021/bi060878o
Related
pathway
sre00051  Fructose and mannose metabolism
sre00511  Other glycan degradation
sre00513  Various types of N-glycan biosynthesis
sre00515  Mannose type O-glycan biosynthesis
sre00520  Amino sugar and nucleotide sugar metabolism
sre00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
sre00900  Terpenoid backbone biosynthesis
KO pathway
ko00510   

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