KEGG   PATHWAY: tup03320
Entry
tup03320                    Pathway                                
Name
PPAR signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
tup03320  PPAR signaling pathway
tup03320

Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102467857  APOA2; apolipoprotein A2 [KO:K08758]
102467902  FABP2; fatty acid binding protein 2 [KO:K08751]
102469428  HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 [KO:K01641] [EC:2.3.3.10]
102469638  GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
102469718  HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 [KO:K01641] [EC:2.3.3.10]
102470154  PLIN2; perilipin 2 [KO:K17284]
102470277  RXRA; retinoid X receptor alpha [KO:K08524]
102470441  ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
102470906  NR1H3; nuclear receptor subfamily 1 group H member 3 [KO:K08536]
102471009  [KO:K00488] [EC:1.14.15.15]
102472729  SLC27A4; solute carrier family 27 member 4 [KO:K08745] [EC:6.2.1.-]
102473504  ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
102473651  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
102473669  [KO:K07425] [EC:1.14.14.80]
102473766  UCP1; uncoupling protein 1 [KO:K08769]
102473798  ACSL4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
102474069  SLC27A1; solute carrier family 27 member 1 [KO:K08745] [EC:6.2.1.-]
102474268  [KO:K15013] [EC:6.2.1.3]
102474347  [KO:K07425] [EC:1.14.14.80]
102475321  ACSL1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
102475407  FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
102476589  [KO:K07425] [EC:1.14.14.80]
102477006  [KO:K07425] [EC:1.14.14.80]
102477357  FABP3; fatty acid binding protein 3 [KO:K08752]
102477589  DBI; diazepam binding inhibitor, acyl-CoA binding protein [KO:K08762]
102478047  PLIN4; perilipin 4 [KO:K20254]
102478064  RXRG; retinoid X receptor gamma [KO:K08526]
102478161  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
102478480  PLIN5; perilipin-5 [KO:K20255]
102478620  FABP5; fatty acid binding protein 5 [KO:K08754]
102478785  ACADL; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
102479742  [KO:K07431] [EC:1.14.14.139]
102479874  FABP4; fatty acid binding protein 4 [KO:K08753]
102480145  CD36; CD36 molecule [KO:K06259]
102480340  AQP7; aquaporin 7 [KO:K08771]
102480882  FABP7; fatty acid binding protein 7 [KO:K08756]
102481324  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
102482193  ACOX1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]
102482248  [KO:K08762]
102482729  ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
102483776  SLC27A5; solute carrier family 27 member 5 [KO:K08748] [EC:6.2.1.7]
102485230  PLTP; phospholipid transfer protein [KO:K08761]
102485369  [KO:K00489] [EC:1.14.14.23]
102485726  CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
102486238  OLR1; oxidized low density lipoprotein receptor 1 [KO:K08763]
102486878  ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
102486942  CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
102487249  SCP2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
102488039  ME1; malic enzyme 1 [KO:K00029] [EC:1.1.1.40]
102488757  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102489479  MMP1; matrix metallopeptidase 1 [KO:K01388] [EC:3.4.24.7]
102490608  [KO:K01388] [EC:3.4.24.7]
102491187  ACOX2; acyl-CoA oxidase 2 [KO:K10214] [EC:1.17.99.3]
102492328  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
102492581  SLC27A2; solute carrier family 27 member 2 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
102493141  FABP1; fatty acid binding protein 1 [KO:K08750]
102493479  ME3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
102493851  CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
102493984  ACSL3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
102494254  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
102495121  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
102495243  RXRB; retinoid X receptor beta [KO:K08525]
102495447  GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
102496120  PLIN1; perilipin 1 [KO:K08768]
102496619  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102497099  [KO:K07425] [EC:1.14.14.80]
102497106  FABP6; fatty acid binding protein 6 [KO:K08755]
102497171  SLC27A6; solute carrier family 27 member 6 [KO:K08749]
102497633  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102498195  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
102498565  PPARD; peroxisome proliferator activated receptor delta [KO:K04504]
102499154  SORBS1; sorbin and SH3 domain containing 1 [KO:K06086]
102499623  ACSL5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
102499751  ACSL6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
102499831  ANGPTL4; angiopoietin like 4 [KO:K08767]
102500065  ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
102500158  APOA1; apolipoprotein A1 [KO:K08757]
102500565  APOC3; apolipoprotein C3 [KO:K08759]
102500809  UBC; ubiquitin C [KO:K08770]
102501391  APOA5; apolipoprotein A5 [KO:K09025]
102502891  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
102503149  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
tup00071  Fatty acid degradation
tup00120  Primary bile acid biosynthesis
tup00564  Glycerophospholipid metabolism
tup04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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