KEGG   PATHWAY: umr03015
Entry
umr03015                    Pathway                                
Name
mRNA surveillance pathway - Ursus maritimus (polar bear)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
umr03015  mRNA surveillance pathway
umr03015

Other DBs
GO: 0071028
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656692  CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
103656765  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
103656971  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
103657060  SYMPK; symplekin [KO:K06100]
103657330  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X5 [KO:K03456]
103657609  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
103657887  FUS; RNA-binding protein FUS isoform X2 [KO:K13098]
103657944  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
103658340  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103658377  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
103658565  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
103659105  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103659340  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
103659864  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
103660911  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
103661277  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103661506  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
103661726  CASC3; protein CASC3 [KO:K14323]
103661911  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
103662531  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103663382  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
103663691  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103663780  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
103664157  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
103664286  SAP18; histone deacetylase complex subunit SAP18 isoform X3 [KO:K14324]
103664635  PELO; protein pelota homolog [KO:K06965]
103665698  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
103665801  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103665803  PNN; pinin [KO:K13114]
103666001  ALYREF; THO complex subunit 4 [KO:K12881]
103666113  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103666119  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
103666328  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103666351  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
103666539  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
103666662  [KO:K23600]
103667155  SMG6; telomerase-binding protein EST1A isoform X2 [KO:K11124] [EC:3.1.-.-]
103667365  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
103668324  [KO:K15544] [EC:3.1.3.16]
103668496  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
103668609  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
103668640  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
103668687  SMG5; protein SMG5 isoform X1 [KO:K11125]
103668916  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
103669121  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
103669880  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
103669986  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
103670094  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
103670281  GLE1; nucleoporin GLE1 [KO:K18723]
103670697  MAGOH; protein mago nashi homolog [KO:K12877]
103670955  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
103671290  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
103671909  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103671993  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
103671999  [KO:K13126]
103672380  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103672411  SMG7; protein SMG7 isoform X1 [KO:K14409]
103672470  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103672802  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
103673006  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
103673291  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103673567  [KO:K18655] [EC:5.6.2.7]
103673570  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
103673632  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
103673782  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
103673960  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
103674768  WDR82; WD repeat-containing protein 82 [KO:K14962]
103674888  NXF3; nuclear RNA export factor 3 [KO:K14284]
103674958  [KO:K14284]
103674968  [KO:K14284]
103675079  [KO:K14284]
103675150  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103675328  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X2 [KO:K14400]
103676269  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
103676303  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
103677741  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
103677857  NXT1; NTF2-related export protein 1 [KO:K14285]
103678002  [KO:K15544] [EC:3.1.3.16]
103678163  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X5 [KO:K14398]
103678204  NXF1; nuclear RNA export factor 1 [KO:K14284]
103678354  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
103678408  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
103678619  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
103678867  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
103678927  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
103679434  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
103679611  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103679745  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
103680479  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
103680846  [KO:K13126]
103681036  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
103681044  [KO:K14396]
103681637  DAZAP1; LOW QUALITY PROTEIN: DAZ-associated protein 1 [KO:K14411]
103682069  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
103682342  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
103682470  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
121100753  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121103725  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
umr03013  Nucleocytoplasmic transport
umr03018  RNA degradation
umr03040  Spliceosome
KO pathway
ko03015   

DBGET integrated database retrieval system