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ENTRY	nt06219
Name	JAK-STAT signaling (cancer)
Category	Disease view; Cancer signaling
Display	drug-target relation   disease type

N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N00181    vIL6 → IL6ST → JAK2 → STAT3 N00491    P12 → IL2RB/G → JAK1/3 → STAT5 ⇒ IL2   N00094    EGF → EGFR → JAK1 → STAT1/3/5 N10009        (Trastuzumab,Trastuzumab_emtansine,Pertuzumab,Lapatinib,Neratinib,Tucatinib,Margetuximab) ⊥ N00095    EGF → (ERBB2*+EGFR) → JAK1 → STAT1/3 ⇒ VEGFA N10003        Crizotinib ⊥ N10004        (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00105        EML4-ALK → JAK3 → STAT3,STAT5 N10001            Imatinib ⊥ N10002            (Dasatinib,Nilotinib,Bostinib,Ponatinib,Asciminib) ⊥ N00055            BCR-ABL → STAT5 ⇒ BCL2L1 N00219        FLT3LG → FLT3 → STAT5 N00054            FLT3* → STAT5 ⇒ PIM1/2   N01340    ACh → CHRNA7 → JAK2 → STAT3 N01341    (NNK,NNN) → CHRNA7 → JAK2 → STAT3 ⇒ IKBKE N01342    Nicotine → (CHRNA4+CHRNB2) → JAK2 → STAT3 ⇒ CCND1