KEGG   Homo sapiens (human): 3558
Entry
3558              CDS       T01001                                 
Symbol
IL2, IL-2, TCGF, lymphokine
Name
(RefSeq) interleukin 2
  KO
K05429  interleukin 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04151  PI3K-Akt signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00491  HTLV-1 p12 to Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00084  Graft-versus-host disease
H00408  Type 1 diabetes mellitus
Drug target
Eciskafusp alfa: D12791
Imneskibart: D12850
Pegenzileukin: D12625
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3558 (IL2)
   04151 PI3K-Akt signaling pathway
    3558 (IL2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3558 (IL2)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3558 (IL2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    3558 (IL2)
   04660 T cell receptor signaling pathway
    3558 (IL2)
   04658 Th1 and Th2 cell differentiation
    3558 (IL2)
   04659 Th17 cell differentiation
    3558 (IL2)
   04672 Intestinal immune network for IgA production
    3558 (IL2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3558 (IL2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3558 (IL2)
   05171 Coronavirus disease - COVID-19
    3558 (IL2)
   05162 Measles
    3558 (IL2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    3558 (IL2)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    3558 (IL2)
  09163 Immune disease
   05320 Autoimmune thyroid disease
    3558 (IL2)
   05321 Inflammatory bowel disease
    3558 (IL2)
   05330 Allograft rejection
    3558 (IL2)
   05332 Graft-versus-host disease
    3558 (IL2)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3558 (IL2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3558 (IL2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3558 (IL2)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3558 (IL2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3558 (IL2)
SSDB
Motif
Pfam: IL2 Plasmid_RAQPRD Portal_Gp20
Other DBs
NCBI-GeneID: 3558
NCBI-ProteinID: NP_000577
OMIM: 147680
HGNC: 6001
Ensembl: ENSG00000109471
UniProt: P60568 Q0GK43
Structure
LinkDB
Position
4:complement(122451470..122456725)
AA seq 153 aa
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT
NT seq 462 nt   +upstreamnt  +downstreamnt
atgtacaggatgcaactcctgtcttgcattgcactaagtcttgcacttgtcacaaacagt
gcacctacttcaagttctacaaagaaaacacagctacaactggagcatttactgctggat
ttacagatgattttgaatggaattaataattacaagaatcccaaactcaccaggatgctc
acatttaagttttacatgcccaagaaggccacagaactgaaacatcttcagtgtctagaa
gaagaactcaaacctctggaggaagtgctaaatttagctcaaagcaaaaactttcactta
agacccagggacttaatcagcaatatcaacgtaatagttctggaactaaagggatctgaa
acaacattcatgtgtgaatatgctgatgagacagcaaccattgtagaatttctgaacaga
tggattaccttttgtcaaagcatcatctcaacactgacttga

KEGG   Homo sapiens (human): 3562
Entry
3562              CDS       T01001                                 
Symbol
IL3, IL-3, MCGF, MULTI-CSF
Name
(RefSeq) interleukin 3
  KO
K04736  interleukin 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04664  Fc epsilon RI signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
hsa05310  Asthma
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00116  Mutation-inactivated RUNX1 to transcription
N00118  TEL-AML1 fusion to transcriptional repression
N01804  IL3 family to Jak-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3562 (IL3)
   04151 PI3K-Akt signaling pathway
    3562 (IL3)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3562 (IL3)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    3562 (IL3)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3562 (IL3)
   04664 Fc epsilon RI signaling pathway
    3562 (IL3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3562 (IL3)
   05202 Transcriptional misregulation in cancer
    3562 (IL3)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    3562 (IL3)
  09163 Immune disease
   05310 Asthma
    3562 (IL3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3562 (IL3)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3562 (IL3)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3562 (IL3)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3562 (IL3)
SSDB
Motif
Pfam: IL3 Ldl_recept_b
Other DBs
NCBI-GeneID: 3562
NCBI-ProteinID: NP_000579
OMIM: 147740
HGNC: 6011
Ensembl: ENSG00000164399
UniProt: P08700
Structure
LinkDB
Position
5:132060655..132063204
AA seq 152 aa
MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLN
GEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKD
GDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF
NT seq 459 nt   +upstreamnt  +downstreamnt
atgagccgcctgcccgtcctgctcctgctccaactcctggtccgccccggactccaagct
cccatgacccagacaacgcccttgaagacaagctgggttaactgctctaacatgatcgat
gaaattataacacacttaaagcagccacctttgcctttgctggacttcaacaacctcaat
ggggaagaccaagacattctgatggaaaataaccttcgaaggccaaacctggaggcattc
aacagggctgtcaagagtttacagaacgcatcagcaattgagagcattcttaaaaatctc
ctgccatgtctgcccctggccacggccgcacccacgcgacatccaatccatatcaaggac
ggtgactggaatgaattccggaggaaactgacgttctatctgaaaacccttgagaatgcg
caggctcaacagacgactttgagcctcgcgatcttttga

KEGG   Homo sapiens (human): 3565
Entry
3565              CDS       T01001                                 
Symbol
IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4
Name
(RefSeq) interleukin 4
  KO
K05430  interleukin 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05140  Leishmaniasis
hsa05200  Pathways in cancer
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00079  Asthma
Drug target
Binetrakin: D03117
Pascolizumab: D05377
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3565 (IL4)
   04151 PI3K-Akt signaling pathway
    3565 (IL4)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3565 (IL4)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3565 (IL4)
   04660 T cell receptor signaling pathway
    3565 (IL4)
   04658 Th1 and Th2 cell differentiation
    3565 (IL4)
   04659 Th17 cell differentiation
    3565 (IL4)
   04657 IL-17 signaling pathway
    3565 (IL4)
   04664 Fc epsilon RI signaling pathway
    3565 (IL4)
   04672 Intestinal immune network for IgA production
    3565 (IL4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3565 (IL4)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    3565 (IL4)
  09163 Immune disease
   05310 Asthma
    3565 (IL4)
   05320 Autoimmune thyroid disease
    3565 (IL4)
   05321 Inflammatory bowel disease
    3565 (IL4)
   05330 Allograft rejection
    3565 (IL4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3565 (IL4)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3565 (IL4)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3565 (IL4)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3565 (IL4)
SSDB
Motif
Pfam: IL4 Mannosyl_trans3
Other DBs
NCBI-GeneID: 3565
NCBI-ProteinID: NP_000580
OMIM: 147780
HGNC: 6014
Ensembl: ENSG00000113520
UniProt: P05112 D4HNR6
Structure
LinkDB
Position
5:132673989..132682678
AA seq 153 aa
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS
NT seq 462 nt   +upstreamnt  +downstreamnt
atgggtctcacctcccaactgcttccccctctgttcttcctgctagcatgtgccggcaac
tttgtccacggacacaagtgcgatatcaccttacaggagatcatcaaaactttgaacagc
ctcacagagcagaagactctgtgcaccgagttgaccgtaacagacatctttgctgcctcc
aagaacacaactgagaaggaaaccttctgcagggctgcgactgtgctccggcagttctac
agccaccatgagaaggacactcgctgcctgggtgcgactgcacagcagttccacaggcac
aagcagctgatccgattcctgaaacggctcgacaggaacctctggggcctggcgggcttg
aattcctgtcctgtgaaggaagccaaccagagtacgttggaaaacttcttggaaaggcta
aagacgatcatgagagagaaatattcaaagtgttcgagctga

KEGG   Homo sapiens (human): 3567
Entry
3567              CDS       T01001                                 
Symbol
IL5, EDF, IL-5, TRF
Name
(RefSeq) interleukin 5
  KO
K05428  interleukin 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05200  Pathways in cancer
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01804  IL3 family to Jak-STAT signaling pathway
Drug target
Depemokimab: D12169
Mepolizumab: D04923<JP/US>
Reslizumab: D08985<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3567 (IL5)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3567 (IL5)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3567 (IL5)
   04660 T cell receptor signaling pathway
    3567 (IL5)
   04658 Th1 and Th2 cell differentiation
    3567 (IL5)
   04657 IL-17 signaling pathway
    3567 (IL5)
   04664 Fc epsilon RI signaling pathway
    3567 (IL5)
   04672 Intestinal immune network for IgA production
    3567 (IL5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3567 (IL5)
  09163 Immune disease
   05310 Asthma
    3567 (IL5)
   05320 Autoimmune thyroid disease
    3567 (IL5)
   05321 Inflammatory bowel disease
    3567 (IL5)
   05330 Allograft rejection
    3567 (IL5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3567 (IL5)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3567 (IL5)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3567 (IL5)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3567 (IL5)
SSDB
Motif
Pfam: IL5 DUF6034
Other DBs
NCBI-GeneID: 3567
NCBI-ProteinID: NP_000870
OMIM: 147850
HGNC: 6016
Ensembl: ENSG00000113525
UniProt: P05113
Structure
LinkDB
Position
5:complement(132541445..132556815)
AA seq 134 aa
MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNH
QLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQ
EFLGVMNTEWIIES
NT seq 405 nt   +upstreamnt  +downstreamnt
atgaggatgcttctgcatttgagtttgctagctcttggagctgcctacgtgtatgccatc
cccacagaaattcccacaagtgcattggtgaaagagaccttggcactgctttctactcat
cgaactctgctgatagccaatgagactctgaggattcctgttcctgtacataaaaatcac
caactgtgcactgaagaaatctttcagggaataggcacactggagagtcaaactgtgcaa
gggggtactgtggaaagactattcaaaaacttgtccttaataaagaaatacattgacggc
caaaaaaaaaagtgtggagaagaaagacggagagtaaaccaattcctagactacctgcaa
gagtttcttggtgtaatgaacaccgagtggataatagaaagttga

KEGG   Homo sapiens (human): 3569
Entry
3569              CDS       T01001                                 
Symbol
IL6, BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Name
(RefSeq) interleukin 6
  KO
K05405  interleukin 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01523  Antifolate resistance
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04659  Th17 cell differentiation
hsa04668  TNF signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05332  Graft-versus-host disease
hsa05410  Hypertrophic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06183  Yersinia
nt06219  JAK-STAT signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06517  TLR signaling
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00139  FUS-DDIT3 fusion to CEBPB-mediated transcription
N00317  AhR signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01306  AngII-AT1R-NOX2 signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01556  IL6 family to Jak-STAT signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H00084  Graft-versus-host disease
H00286  Crohn disease
H00630  Rheumatoid arthritis
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis
Drug target
Olokizumab: D12487
Pirfenidone: D01583<JP/US>
Pomalidomide: D08976<JP/US>
Siltuximab: D09669<US>
Sirukumab: D10080
Ziltivekimab: D12807
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3569 (IL6)
   04668 TNF signaling pathway
    3569 (IL6)
   04066 HIF-1 signaling pathway
    3569 (IL6)
   04068 FoxO signaling pathway
    3569 (IL6)
   04151 PI3K-Akt signaling pathway
    3569 (IL6)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3569 (IL6)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3569 (IL6)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    3569 (IL6)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3569 (IL6)
   04620 Toll-like receptor signaling pathway
    3569 (IL6)
   04621 NOD-like receptor signaling pathway
    3569 (IL6)
   04623 Cytosolic DNA-sensing pathway
    3569 (IL6)
   04625 C-type lectin receptor signaling pathway
    3569 (IL6)
   04659 Th17 cell differentiation
    3569 (IL6)
   04657 IL-17 signaling pathway
    3569 (IL6)
   04672 Intestinal immune network for IgA production
    3569 (IL6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3569 (IL6)
   05202 Transcriptional misregulation in cancer
    3569 (IL6)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3569 (IL6)
   05161 Hepatitis B
    3569 (IL6)
   05171 Coronavirus disease - COVID-19
    3569 (IL6)
   05164 Influenza A
    3569 (IL6)
   05162 Measles
    3569 (IL6)
   05168 Herpes simplex virus 1 infection
    3569 (IL6)
   05163 Human cytomegalovirus infection
    3569 (IL6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3569 (IL6)
   05169 Epstein-Barr virus infection
    3569 (IL6)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3569 (IL6)
   05132 Salmonella infection
    3569 (IL6)
   05135 Yersinia infection
    3569 (IL6)
   05133 Pertussis
    3569 (IL6)
   05134 Legionellosis
    3569 (IL6)
   05152 Tuberculosis
    3569 (IL6)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3569 (IL6)
   05144 Malaria
    3569 (IL6)
   05142 Chagas disease
    3569 (IL6)
   05143 African trypanosomiasis
    3569 (IL6)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3569 (IL6)
   05321 Inflammatory bowel disease
    3569 (IL6)
   05332 Graft-versus-host disease
    3569 (IL6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3569 (IL6)
   05020 Prion disease
    3569 (IL6)
   05022 Pathways of neurodegeneration - multiple diseases
    3569 (IL6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3569 (IL6)
   05410 Hypertrophic cardiomyopathy
    3569 (IL6)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    3569 (IL6)
   04932 Non-alcoholic fatty liver disease
    3569 (IL6)
   04931 Insulin resistance
    3569 (IL6)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3569 (IL6)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3569 (IL6)
   01523 Antifolate resistance
    3569 (IL6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3569 (IL6)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3569 (IL6)
SSDB
Motif
Pfam: IL6 IL11 IL23 Phage_int_SAM_1 GCSF
Other DBs
NCBI-GeneID: 3569
NCBI-ProteinID: NP_000591
OMIM: 147620
HGNC: 6018
Ensembl: ENSG00000136244
UniProt: P05231 Q75MH2 B4DVM1
Structure
LinkDB
Position
7:22727200..22731998
AA seq 212 aa
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
NT seq 639 nt   +upstreamnt  +downstreamnt
atgaactccttctccacaagcgccttcggtccagttgccttctccctggggctgctcctg
gtgttgcctgctgccttccctgccccagtacccccaggagaagattccaaagatgtagcc
gccccacacagacagccactcacctcttcagaacgaattgacaaacaaattcggtacatc
ctcgacggcatctcagccctgagaaaggagacatgtaacaagagtaacatgtgtgaaagc
agcaaagaggcactggcagaaaacaacctgaaccttccaaagatggctgaaaaagatgga
tgcttccaatctggattcaatgaggagacttgcctggtgaaaatcatcactggtcttttg
gagtttgaggtatacctagagtacctccagaacagatttgagagtagtgaggaacaagcc
agagctgtgcagatgagtacaaaagtcctgatccagttcctgcagaaaaaggcaaagaat
ctagatgcaataaccacccctgacccaaccacaaatgccagcctgctgacgaagctgcag
gcacagaaccagtggctgcaggacatgacaactcatctcattctgcgcagctttaaggag
ttcctgcagtccagcctgagggctcttcggcaaatgtag

KEGG   Homo sapiens (human): 3574
Entry
3574              CDS       T01001                                 
Symbol
IL7, IL-7
Name
(RefSeq) interleukin 7
  KO
K05431  interleukin 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Disease
H00842  Epidermodysplasia verruciformis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3574 (IL7)
   04151 PI3K-Akt signaling pathway
    3574 (IL7)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3574 (IL7)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3574 (IL7)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3574 (IL7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3574 (IL7)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3574 (IL7)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3574 (IL7)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3574 (IL7)
SSDB
Motif
Pfam: IL7
Other DBs
NCBI-GeneID: 3574
NCBI-ProteinID: NP_000871
OMIM: 146660
HGNC: 6023
Ensembl: ENSG00000104432
UniProt: P13232 A8K673
Structure
LinkDB
Position
8:complement(78675044..78805463)
AA seq 177 aa
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCL
NNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQ
VKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
NT seq 534 nt   +upstreamnt  +downstreamnt
atgttccatgtttcttttaggtatatctttggacttcctcccctgatccttgttctgttg
ccagtagcatcatctgattgtgatattgaaggtaaagatggcaaacaatatgagagtgtt
ctaatggtcagcatcgatcaattattggacagcatgaaagaaattggtagcaattgcctg
aataatgaatttaacttttttaaaagacatatctgtgatgctaataaggaaggtatgttt
ttattccgtgctgctcgcaagttgaggcaatttcttaaaatgaatagcactggtgatttt
gatctccacttattaaaagtttcagaaggcacaacaatactgttgaactgcactggccag
gttaaaggaagaaaaccagctgccctgggtgaagcccaaccaacaaagagtttggaagaa
aataaatctttaaaggaacagaaaaaactgaatgacttgtgtttcctaaagagactatta
caagagataaaaacttgttggaataaaattttgatgggcactaaagaacactga

KEGG   Homo sapiens (human): 3592
Entry
3592              CDS       T01001                                 
Symbol
IL12A, CLMF, IL-12A, NFSK, NKSF1, P35
Name
(RefSeq) interleukin 12A
  KO
K05406  interleukin 12A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04936  Alcoholic liver disease
hsa04940  Type I diabetes mellitus
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06183  Yersinia
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557  IL12/23 to Jak-STAT signaling pathway
N01566  TLR5-NFKB signaling pathway
Drug target
Apilimod mesylate: D06556
Briakinumab: D09588
Lisofylline: D04748
Ustekinumab: D09214<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3592 (IL12A)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3592 (IL12A)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3592 (IL12A)
   04622 RIG-I-like receptor signaling pathway
    3592 (IL12A)
   04625 C-type lectin receptor signaling pathway
    3592 (IL12A)
   04658 Th1 and Th2 cell differentiation
    3592 (IL12A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3592 (IL12A)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    3592 (IL12A)
   05164 Influenza A
    3592 (IL12A)
   05162 Measles
    3592 (IL12A)
   05168 Herpes simplex virus 1 infection
    3592 (IL12A)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3592 (IL12A)
   05134 Legionellosis
    3592 (IL12A)
   05152 Tuberculosis
    3592 (IL12A)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3592 (IL12A)
   05144 Malaria
    3592 (IL12A)
   05145 Toxoplasmosis
    3592 (IL12A)
   05140 Leishmaniasis
    3592 (IL12A)
   05142 Chagas disease
    3592 (IL12A)
   05143 African trypanosomiasis
    3592 (IL12A)
  09163 Immune disease
   05321 Inflammatory bowel disease
    3592 (IL12A)
   05330 Allograft rejection
    3592 (IL12A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3592 (IL12A)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3592 (IL12A)
   04936 Alcoholic liver disease
    3592 (IL12A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3592 (IL12A)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3592 (IL12A)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3592 (IL12A)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3592 (IL12A)
SSDB
Motif
Pfam: IL12
Other DBs
NCBI-GeneID: 3592
NCBI-ProteinID: NP_000873
OMIM: 161560
HGNC: 5969
Ensembl: ENSG00000168811
UniProt: P29459 O60595
Structure
LinkDB
Position
3:159988835..159996019
AA seq 253 aa
MWPPGSASQPPPSPAAATGLHPAARPVSLQCRLSMCPARSLLLVATLVLLDHLSLARNLP
VATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACL
PLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLL
MDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRA
VTIDRVMSYLNAS
NT seq 762 nt   +upstreamnt  +downstreamnt
atgtggccccctgggtcagcctcccagccaccgccctcacctgccgcggccacaggtctg
catccagcggctcgccctgtgtccctgcagtgccggctcagcatgtgtccagcgcgcagc
ctcctccttgtggctaccctggtcctcctggaccacctcagtttggccagaaacctcccc
gtggccactccagacccaggaatgttcccatgccttcaccactcccaaaacctgctgagg
gccgtcagcaacatgctccagaaggccagacaaactctagaattttacccttgcacttct
gaagagattgatcatgaagatatcacaaaagataaaaccagcacagtggaggcctgttta
ccattggaattaaccaagaatgagagttgcctaaattccagagagacctctttcataact
aatgggagttgcctggcctccagaaagacctcttttatgatggccctgtgccttagtagt
atttatgaagacttgaagatgtaccaggtggagttcaagaccatgaatgcaaagcttctg
atggatcctaagaggcagatctttctagatcaaaacatgctggcagttattgatgagctg
atgcaggccctgaatttcaacagtgagactgtgccacaaaaatcctcccttgaagaaccg
gatttttataaaactaaaatcaagctctgcatacttcttcatgctttcagaattcgggca
gtgactattgatagagtgatgagctatctgaatgcttcctaa

KEGG   Homo sapiens (human): 3593
Entry
3593              CDS       T01001                                 
Symbol
IL12B, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2
Name
(RefSeq) interleukin 12B
  KO
K05425  interleukin 12B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04936  Alcoholic liver disease
hsa04940  Type I diabetes mellitus
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05321  Inflammatory bowel disease
hsa05330  Allograft rejection
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06183  Yersinia
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557  IL12/23 to Jak-STAT signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H00089  IFN-gamma/IL-12 axis
Drug target
Apilimod mesylate: D06556
Briakinumab: D09588
Lisofylline: D04748
Ustekinumab: D09214<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3593 (IL12B)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3593 (IL12B)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3593 (IL12B)
   04622 RIG-I-like receptor signaling pathway
    3593 (IL12B)
   04625 C-type lectin receptor signaling pathway
    3593 (IL12B)
   04658 Th1 and Th2 cell differentiation
    3593 (IL12B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3593 (IL12B)
   05205 Proteoglycans in cancer
    3593 (IL12B)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    3593 (IL12B)
   05164 Influenza A
    3593 (IL12B)
   05162 Measles
    3593 (IL12B)
   05168 Herpes simplex virus 1 infection
    3593 (IL12B)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3593 (IL12B)
   05134 Legionellosis
    3593 (IL12B)
   05152 Tuberculosis
    3593 (IL12B)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3593 (IL12B)
   05145 Toxoplasmosis
    3593 (IL12B)
   05140 Leishmaniasis
    3593 (IL12B)
   05142 Chagas disease
    3593 (IL12B)
   05143 African trypanosomiasis
    3593 (IL12B)
  09163 Immune disease
   05321 Inflammatory bowel disease
    3593 (IL12B)
   05330 Allograft rejection
    3593 (IL12B)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3593 (IL12B)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3593 (IL12B)
   04936 Alcoholic liver disease
    3593 (IL12B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3593 (IL12B)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3593 (IL12B)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3593 (IL12B)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3593 (IL12B)
SSDB
Motif
Pfam: IL12p40_C Ig_3 Ig_5 Ig_2 Ig_4 fn3 ig
Other DBs
NCBI-GeneID: 3593
NCBI-ProteinID: NP_002178
OMIM: 161561
HGNC: 5970
Ensembl: ENSG00000113302
UniProt: P29460
Structure
LinkDB
Position
5:complement(159314780..159330487)
AA seq 328 aa
MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITW
TLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQ
KEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERV
RGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKN
LQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVIC
RKNASISVRAQDRYYSSSWSEWASVPCS
NT seq 987 nt   +upstreamnt  +downstreamnt
atgtgtcaccagcagttggtcatctcttggttttccctggtttttctggcatctcccctc
gtggccatatgggaactgaagaaagatgtttatgtcgtagaattggattggtatccggat
gcccctggagaaatggtggtcctcacctgtgacacccctgaagaagatggtatcacctgg
accttggaccagagcagtgaggtcttaggctctggcaaaaccctgaccatccaagtcaaa
gagtttggagatgctggccagtacacctgtcacaaaggaggcgaggttctaagccattcg
ctcctgctgcttcacaaaaaggaagatggaatttggtccactgatattttaaaggaccag
aaagaacccaaaaataagacctttctaagatgcgaggccaagaattattctggacgtttc
acctgctggtggctgacgacaatcagtactgatttgacattcagtgtcaaaagcagcaga
ggctcttctgacccccaaggggtgacgtgcggagctgctacactctctgcagagagagtc
agaggggacaacaaggagtatgagtactcagtggagtgccaggaggacagtgcctgccca
gctgctgaggagagtctgcccattgaggtcatggtggatgccgttcacaagctcaagtat
gaaaactacaccagcagcttcttcatcagggacatcatcaaacctgacccacccaagaac
ttgcagctgaagccattaaagaattctcggcaggtggaggtcagctgggagtaccctgac
acctggagtactccacattcctacttctccctgacattctgcgttcaggtccagggcaag
agcaagagagaaaagaaagatagagtcttcacggacaagacctcagccacggtcatctgc
cgcaaaaatgccagcattagcgtgcgggcccaggaccgctactatagctcatcttggagc
gaatgggcatctgtgccctgcagttag

KEGG   Homo sapiens (human): 3596
Entry
3596              CDS       T01001                                 
Symbol
IL13, IL-13, P600
Name
(RefSeq) interleukin 13
  KO
K05435  interleukin 13
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04664  Fc epsilon RI signaling pathway
hsa05200  Pathways in cancer
hsa05310  Asthma
hsa05321  Inflammatory bowel disease
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01556  IL6 family to Jak-STAT signaling pathway
Disease
H00079  Asthma
H00084  Graft-versus-host disease
H01360  Allergic rhinitis
Drug target
Anrukinzumab: D08857
Cendakimab: D11843
Lebrikizumab: D09633<JP>
Romilkimab: D11598
Tralokinumab: D09979<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3596 (IL13)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3596 (IL13)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    3596 (IL13)
   04657 IL-17 signaling pathway
    3596 (IL13)
   04664 Fc epsilon RI signaling pathway
    3596 (IL13)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3596 (IL13)
  09163 Immune disease
   05310 Asthma
    3596 (IL13)
   05321 Inflammatory bowel disease
    3596 (IL13)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3596 (IL13)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3596 (IL13)
SSDB
Motif
Pfam: IL13
Other DBs
NCBI-GeneID: 3596
NCBI-ProteinID: NP_002179
OMIM: 147683
HGNC: 5973
Ensembl: ENSG00000169194
UniProt: P35225
Structure
LinkDB
Position
5:132656522..132661110
AA seq 146 aa
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAP
LCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRD
TKIEVAQFVKDLLLHLKKLFREGQFN
NT seq 441 nt   +upstreamnt  +downstreamnt
atgcatccgctcctcaatcctctcctgttggcactgggcctcatggcgcttttgttgacc
acggtcattgctctcacttgccttggcggctttgcctccccaggccctgtgcctccctct
acagccctcagggagctcattgaggagctggtcaacatcacccagaaccagaaggctccg
ctctgcaatggcagcatggtatggagcatcaacctgacagctggcatgtactgtgcagcc
ctggaatccctgatcaacgtgtcaggctgcagtgccatcgagaagacccagaggatgctg
agcggattctgcccgcacaaggtctcagctgggcagttttccagcttgcatgtccgagac
accaaaatcgaggtggcccagtttgtaaaggacctgctcttacatttaaagaaacttttt
cgcgagggacagttcaactga

KEGG   Homo sapiens (human): 3600
Entry
3600              CDS       T01001                                 
Symbol
IL15, IL-15
Name
(RefSeq) interleukin 15
  KO
K05433  interleukin 15
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04668  TNF signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05323  Rheumatoid arthritis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N01554  IL2 family to Jak-STAT signaling pathway
Drug target
Ordesekimab: D12306
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3600 (IL15)
   04668 TNF signaling pathway
    3600 (IL15)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3600 (IL15)
 09150 Organismal Systems
  09151 Immune system
   04672 Intestinal immune network for IgA production
    3600 (IL15)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3600 (IL15)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3600 (IL15)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3600 (IL15)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3600 (IL15)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3600 (IL15)
SSDB
Motif
Pfam: IL15
Other DBs
NCBI-GeneID: 3600
NCBI-ProteinID: NP_000576
OMIM: 600554
HGNC: 5977
Ensembl: ENSG00000164136
UniProt: P40933
Structure
LinkDB
Position
4:141636583..141733987
AA seq 162 aa
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKI
EDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANN
SLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
NT seq 489 nt   +upstreamnt  +downstreamnt
atgagaatttcgaaaccacatttgagaagtatttccatccagtgctacttgtgtttactt
ctaaacagtcattttctaactgaagctggcattcatgtcttcattttgggctgtttcagt
gcagggcttcctaaaacagaagccaactgggtgaatgtaataagtgatttgaaaaaaatt
gaagatcttattcaatctatgcatattgatgctactttatatacggaaagtgatgttcac
cccagttgcaaagtaacagcaatgaagtgctttctcttggagttacaagttatttcactt
gagtccggagatgcaagtattcatgatacagtagaaaatctgatcatcctagcaaacaac
agtttgtcttctaatgggaatgtaacagaatctggatgcaaagaatgtgaggaactggag
gaaaaaaatattaaagaatttttgcagagttttgtacatattgtccaaatgttcatcaac
acttcttga

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