Entry |
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Symbol |
murF
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Name |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC: 6.3.2.10]
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Pathway |
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Reaction |
R04573 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:alanyl-D-alanine ligase (ADP-forming) |
R04617 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate:D-alanyl-D-alanine ligase (ADP-forming) |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Enzymes [BR:ko01000]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Duncan K, van Heijenoort J, Walsh CT |
Title |
Purification and characterization of the D-alanyl-D-alanine-adding enzyme from Escherichia coli. |
Journal |
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Reference |
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Authors |
Anderson MS, Eveland SS, Onishi HR, Pompliano DL |
Title |
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion. |
Journal |
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Sequence |
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LinkDB |
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