KEGG   PATHWAY: oga04010
Entry
oga04010                    Pathway                                
Name
MAPK signaling pathway - Otolemur garnettii (small-eared galago)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
oga04010  MAPK signaling pathway
oga04010

Other DBs
GO: 0000165
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100940437  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100957337  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100964267  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100953767  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
100955943  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
100962519  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100955208  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X15 [KO:K04854]
100946834  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100966936  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100962683  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100963985  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
100965256  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
100962617  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
100964583  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100958249  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
100947015  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X9 [KO:K04863]
100941047  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
100948836  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100966020  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100961483  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100944112  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100965924  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100965703  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100956248  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100956561  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100967155  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100956403  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100961754  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100961025  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100945846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
105886540  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105887331  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100946682  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
100951960  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
100948727  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100942339  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100955151  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
100961453  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100941053  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X12 [KO:K08018]
100948333  NF1; neurofibromin isoform X1 [KO:K08052]
100956457  RASA1; ras GTPase-activating protein 1 [KO:K04352]
100946726  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
100962069  RAP1A; ras-related protein Rap-1A [KO:K04353]
100959791  RAP1B; ras-related protein Rap-1b [KO:K07836]
100941765  ras-related protein Rap-1b-like protein [KO:K07836]
100959686  EGF; pro-epidermal growth factor [KO:K04357]
100959235  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
100949887  EREG; proepiregulin [KO:K09784]
100952184  AREG; amphiregulin [KO:K09782]
100966077  FGF1; fibroblast growth factor 1 [KO:K18496]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100961245  FGF6; fibroblast growth factor 6 [KO:K04358]
100962391  FGF9; fibroblast growth factor 9 [KO:K04358]
100964809  FGF20; fibroblast growth factor 20 [KO:K04358]
100958629  FGF4; fibroblast growth factor 4 [KO:K04358]
100954515  FGF10; fibroblast growth factor 10 [KO:K04358]
100953298  FGF16; fibroblast growth factor 16 [KO:K04358]
100960938  FGF3; fibroblast growth factor 3 [KO:K04358]
100958585  FGF22; fibroblast growth factor 22 [KO:K04358]
100942388  FGF5; fibroblast growth factor 5 [KO:K04358]
100945380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100948029  FGF18; fibroblast growth factor 18 [KO:K04358]
100947419  FGF7; fibroblast growth factor 7 [KO:K04358]
100940920  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
100961253  FGF19; fibroblast growth factor 19 [KO:K22603]
100947735  FGF21; fibroblast growth factor 21 [KO:K22429]
100958098  FGF23; fibroblast growth factor 23 [KO:K22428]
100946218  NGF; beta-nerve growth factor [KO:K02582]
100958946  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100958737  NTF3; neurotrophin-3 [KO:K04356]
100955816  NTF4; neurotrophin-4 [KO:K12457]
100958310  INS; insulin isoform X1 [KO:K04526]
100951094  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100958631  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
100944643  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100962660  PDGFD; platelet-derived growth factor D [KO:K05450]
100964580  PDGFC; platelet-derived growth factor C [KO:K05450]
100942777  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100949514  KITLG; kit ligand isoform X1 [KO:K05461]
100943945  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100965129  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100967099  VEGFC; vascular endothelial growth factor C [KO:K05449]
100951253  VEGFD; vascular endothelial growth factor D [KO:K05449]
100963467  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100950768  ANGPT1; angiopoietin-1 isoform X2 [KO:K05465]
100953177  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100957394  ANGPT4; angiopoietin-4 [KO:K05467]
100966977  EFNA2; ephrin-A2 [KO:K05462]
100962075  EFNA3; ephrin-A3 [KO:K05462]
100955006  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100961557  EFNA1; ephrin-A1 [KO:K05462]
100962590  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100944309  GDNF; glial cell line-derived neurotrophic factor isoform X5 [KO:K05452]
100940330  NRTN; neurturin [KO:K25414]
100946581  ARTN; artemin [KO:K25415]
100943372  PSPN; persephin [KO:K25416]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100953964  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100966253  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100950688  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100952813  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100962219  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100957667  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100948280  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
100940422  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100956865  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100962237  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
100944394  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100951606  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100952454  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100961872  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100947062  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100946241  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100941807  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100944640  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100948196  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100966523  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100941938  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100942216  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100948262  RRAS; ras-related protein R-Ras [KO:K07829]
100958945  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100967191  MRAS; ras-related protein M-Ras [KO:K07831]
100947929  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100955336  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100959575  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100955096  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
100942287  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K04372] [EC:2.7.11.1]
100950673  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100945202  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
100963421  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X5 [KO:K04373] [EC:2.7.11.1]
100946311  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
100940993  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100949181  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100946001  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100952723  SRF; serum response factor [KO:K04378]
100953435  FOS; proto-oncogene c-Fos [KO:K04379]
100951532  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
100966404  STMN1; stathmin isoform X1 [KO:K04381]
100943950  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105887148  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100965730  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100963523  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100963613  TNF; tumor necrosis factor [KO:K03156]
100961897  IL1A; interleukin-1 alpha [KO:K04383]
100944877  IL1B; interleukin-1 beta [KO:K04519]
100949640  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
100956747  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
100955213  TGFB3; transforming growth factor beta-3 [KO:K13377]
100955892  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100959140  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
100952305  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100953115  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100960821  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
100951008  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100958429  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957182  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100948274  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100947706  cell division control protein 42 homolog [KO:K04393]
100950992  CDC42; cell division control protein 42 homolog [KO:K04393]
100952230  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100966378  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100966127  DAXX; death domain-associated protein 6 [KO:K02308]
100948454  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100951843  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100956612  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100945817  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100946928  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100950782  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100950842  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X2 [KO:K04402]
100949838  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100955970  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100952020  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100957869  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
100947260  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X15 [KO:K04407] [EC:2.7.11.1]
100963642  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100950236  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100967098  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100959420  STK4; serine/threonine-protein kinase 4 [KO:K04411]
100964932  STK3; serine/threonine-protein kinase 3 [KO:K04412]
100944553  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
100953651  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100957675  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100957362  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100959913  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100944704  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
100941407  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100960652  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100962397  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
100966986  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
100964785  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100943238  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
100949934  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
100943232  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100962907  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100949460  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X2 [KO:K04428] [EC:2.7.11.25]
100959460  TAOK2; serine/threonine-protein kinase TAO2 isoform X4 [KO:K04429] [EC:2.7.11.1]
100943679  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
100944934  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
100945898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
100966900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
100955929  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100962457  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100953493  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
100958867  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100944518  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X2 [KO:K04436]
100953848  FLNA; filamin-A isoform X2 [KO:K04437]
100958636  CRK; adapter molecule crk isoform X1 [KO:K04438]
100951208  CRKL; crk-like protein [KO:K04438]
100946246  ARRB1; beta-arrestin-1 [KO:K04439]
100954933  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100957169  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100967053  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100960275  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100948121  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
100966784  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100940882  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100964034  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100941075  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
100962357  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100965098  JUN; transcription factor AP-1 [KO:K04448]
100957768  JUND; transcription factor jun-D [KO:K04449]
100966891  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100956595  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100943049  MAX; protein max isoform X1 [KO:K04453]
100959309  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
100940733  HSPB1; heat shock protein beta-1 [KO:K04455]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100965314  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
100950652  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
100946875  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X2 [KO:K18018] [EC:3.1.3.48]
100961546  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
100945193  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100964438  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100941794  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100963229  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100951294  DUSP2; dual specificity protein phosphatase 2 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100952920  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100945252  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100949185  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100946280  DUSP9; dual specificity protein phosphatase 9 isoform X3 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100941455  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100945236  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100967030  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100940924  PPM1B; protein phosphatase 1B isoform X3 [KO:K04461] [EC:3.1.3.16]
100945458  heat shock 70 kDa protein 1 [KO:K03283]
100959513  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
100956095  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100945147  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100946722  heat shock 70 kDa protein 1 [KO:K03283]
100951161  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
100963374  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
100962878  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100956281  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
100957606  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100956941  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100963289  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100962411  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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PMID:12947395
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Reference
PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Gene 320:3-21 (2003)
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
oga04070  Phosphatidylinositol signaling system
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04210  Apoptosis
oga04310  Wnt signaling pathway
oga04668  TNF signaling pathway
KO pathway
ko04010   
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