KEGG ORTHOLOGY: K09342

ORTHOLOGY: K09342

Entry

K09342                      KO

Symbol

NKX2-1, TITF1

Name

homeobox protein Nkx-2.1

Disease

H00032

Thyroid cancer

H00860

Benign hereditary chorea

H00913

Brain-lung-thyroid syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09342  NKX2-1, TITF1; homeobox protein Nkx-2.1
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain ANTP: NKL
    K09342  NKX2-1, TITF1; homeobox protein Nkx-2.1

Genes

HSA:	7080(NKX2-1)

PTR:	452867(NKX2-1)

PPS:	129392902(NKX2-1)

GGO:	101134297(NKX2-1)

PON:	100435695(NKX2-1)

PPYG:

129012947(NKX2-1)

NLE:	100600935(NKX2-1)

HMH:	116485082(NKX2-1)

SSYN:

129489198(NKX2-1)

MCC:	696771(NKX2-1)

MCF:	135964357(NKX2-1)

MTHB:

126960088

MNI:	105477996(NKX2-1)

CSAB:

103228839(NKX2-1)

CATY:

105589080(NKX2-1)

PANU:

101000504(NKX2-1)

TGE:	112628701(NKX2-1)

MLEU:

105553219(NKX2-1)

RRO:	104663941(NKX2-1)

RBB:	108519664(NKX2-1)

TFN:	117069798(NKX2-1)

PTEH:

111524470(NKX2-1)

CANG:

105500923(NKX2-1)

CJC:	100405396(NKX2-1)

SBQ:	101045016(NKX2-1)

CIMI:

108306072(NKX2-1)

ANAN:

105729857(NKX2-1)

MMUR:

105872766(NKX2-1)

LCAT:

123650019(NKX2-1)

PCOQ:

105821376(NKX2-1)

OGA:	100962061(NKX2-1)

MMU:	21869(Nkx2-1)

MCAL:

110307236(Nkx2-1)

MPAH:

110324416(Nkx2-1)

RNO:	25628(Nkx2-1)

MCOC:

116080612(Nkx2-1)

ANU:	117717171(Nkx2-1)

ASYL:

127686665(Nkx2-1)

MUN:	110561087(Nkx2-1)

CGE:

113836212

MAUA:

101836471(Nkx2-1)

PROB:

127230602(Nkx2-1)

PLEU:

114693408(Nkx2-1)

MORG:

121452525(Nkx2-1)

MFOT:

126499587

AAMP:

119819990(Nkx2-1)

NGI:	103732258(Nkx2-1)

HGL:	101703474(Nkx2-1)

CPOC:

100728815(Nkx2-1)

CCAN:

109678703(Nkx2-1)

DORD:

105982627(Nkx2-1)

DSP:	122106562(Nkx2-1)

PLOP:

125363347(Nkx2-1)

NCAR:

124978044

MMMA:

125615193(Nkx2-1)

ITI:	101969861(Nkx2-1)

OCU:

127483817

OPI:	101517815(NKX2-1)

TUP:	102483512(NKX2-1)

GVR:	103586979(NKX2-1)

CFA:	403940(NKX2-1)

CLUD:

112657637(NKX2-1)

VVP:	112935348(NKX2-1)

VLG:	121493452(NKX2-1)

NPO:	129499340(NKX2-1)

AML:	100465610(NKX2-1)

UMR:	121100295 121100311

UAH:	113266037(NKX2-1)

UAR:	123794262(NKX2-1)

ELK:

111140657

LLV:

125105455

MPUF:

101689780(NKX2-1)

MNP:	131999894(NKX2-1)

MLK:	131836481(NKX2-1)

NVS:	122893887(NKX2-1)

ORO:	101381834(NKX2-1)

EJU:	114208039(NKX2-1)

ZCA:	113908600(NKX2-1)

MLX:	118002239(NKX2-1)

NSU:	110590686(NKX2-1)

LWW:	102731491(NKX2-1)

FCA:	101091876(NKX2-1)

PYU:	121031666(NKX2-1)

PCOO:

112855731

PBG:	122469016(NKX2-1)

PVIV:

125168256(NKX2-1)

LRUF:

124508361

LGF:	123583574(NKX2-1)

AJU:

106965524

PTG:	102965541(NKX2-1)

PPAD:

109253310(NKX2-1)

PUC:

125909557

PLEZ:

122221303(NKX2-1)

HHV:	120247704(NKX2-1)

BTA:	613713(NKX2-1)

BOM:	102273984(NKX2-1)

BIU:	109575328(NKX2-1)

BBUB:

102399584(NKX2-1)

CHX:	108638469(NKX2-1)

OAS:	101121204(NKX2-1)

BTAX:

128066883(NKX2-1)

CSUM:

138095530(NKX2-1)

ODA:	120875072(NKX2-1)

CCAD:

122455110(NKX2-1)

MREE:

136146871(NKX2-1)

OVR:	110152783(NKX2-1)

MBEZ:

129550529(NKX2-1)

SSC:	100154384(NKX2-1)

CFR:	102504535(NKX2-1)

CBAI:

105078479(NKX2-1)

CDK:	105092147(NKX2-1)

VPC:	102545663(NKX2-1)

BACU:

103003595

BMUS:

118890511(NKX2-1)

LVE:

103077930

OOR:	101270034(NKX2-1)

LALB:

132530484(NKX2-1)

DLE:	111173299(NKX2-1)

PCAD:

102982580(NKX2-1)

PSIU:

116749473(NKX2-1)

NASI:

112411149(NKX2-1)

ECB:	100146136(NKX2-1)

EPZ:	139078084(NKX2-1)

EAI:	106838822(NKX2-1)

MYB:	102258416(NKX2-1)

MYD:	102753802(NKX2-1)

MMYO:

118662715(NKX2-1)

MLF:	102423554(NKX2-1)

MDT:	132225920(NKX2-1)

MYUM:

139019032(NKX2-1)

PKL:	118705078(NKX2-1)

EFUS:

103294071(NKX2-1)

MNA:	107526106(NKX2-1)

DRO:	112296567(NKX2-1)

SHON:

118993878(NKX2-1)

AJM:	119062913(NKX2-1)

PDIC:

114493327(NKX2-1)

PHAS:

123825303(NKX2-1)

MMF:	118615207(NKX2-1)

PPAM:

129075972(NKX2-1)

HAI:	109383865(NKX2-1)

RFQ:	117023851(NKX2-1)

PALE:

102889733(NKX2-1)

PGIG:

120620769(NKX2-1)

PVP:	105303111(NKX2-1)

RAY:	107514422(NKX2-1)

MJV:	108387551(NKX2-1)

TOD:	119238254(NKX2-1)

SARA:

101558166(NKX2-1)

SFUM:

130041845(NKX2-1)

SETR:

125998636(NKX2-1)

LAV:	100659703(NKX2-1)

TMU:

101345451

ETF:	101653201(NKX2-1)

DNM:	101440032(NKX2-1)

MDO:	100011516(NKX2-1)

GAS:	123235756(NKX2-1)

SHR:	100918766(NKX2-1)

AFZ:

127549725

PCW:	110211643(NKX2-1)

TVP:	118844704(NKX2-1)

PBRV:

138156961(NKX2-1)

OAA:	100080703(NKX2-1)

TACU:

119937173(NKX2-1)

GGA:	395322(NKX2-1)

PCOC:

116229372(NKX2-1)

MGP:	104911192(NKX2-1)

CJO:	107315058(NKX2-1)

TPAI:

128087362(NKX2-1)

LMUT:

125694825(NKX2-1)

NMEL:

110402062(NKX2-1)

APLA:

101790134(NKX2-1)

ACYG:

106038803(NKX2-1)

CATA:

118244735(NKX2-1)

AFUL:

116490319(NKX2-1)

TGU:	100227803(NKX2-1)

LSR:	110477286(NKX2-1)

SCAN:

115485451(NKX2-1)

PMOA:

120500522(NKX2-1)

OTC:	121333470(NKX2-1)

PRUF:

121356024(NKX2-1)

ATRC:

139589952(NKX2-1)

GFR:	102034824(NKX2-1)

FAB:	101817731(NKX2-1)

OMA:	130253871(NKX2-1)

PHI:	102108499(NKX2-1)

PMAJ:

107206488(NKX2-1)

CCAE:

111922200 111929579(NKX2-1)

CCW:	104684866(NKX2-1)

CBRC:

103620855(NKX2-1)

ACOE:

138110821(NKX2-1)

ETL:	114055968(NKX2-1)

ZAB:	102074264(NKX2-1)

ZLE:	135448245(NKX2-1)

SVG:	106861487(NKX2-1)

MMEA:

130573764(NKX2-1)

HRT:	120754354(NKX2-1)

SATI:

136363041(NKX2-1)

CCIC:

134045460(NKX2-1)

FPG:	101924190(NKX2-1)

FCH:	102058169(NKX2-1)

NNT:	104401074(NKX2-1)

SHAB:

115607462(NKX2-1)

TALA:

116965449(NKX2-1)

ACHC:

115333682(NKX2-1)

HLE:	104841779(NKX2-1)

AGEN:

126049486

HHAR:

128140227(NKX2-1)

GCL:

127017260

LDI:	104341779(NKX2-1)

MNB:	103768138(NKX2-1)

DPUB:

104301098(NKX2-1)

PPUS:

135178256(NKX2-1)

EGZ:	104133299(NKX2-1)

NNI:	104011775(NKX2-1)

PCRI:

104026280

PADL:

103913019

AFOR:

103900095(NKX2-1)

FGA:	104082818(NKX2-1)

CLV:	102098222(NKX2-1)

MUI:	104535362(NKX2-1)

PGUU:

104460380(NKX2-1)

PLET:

104620407(NKX2-1)

EHS:	104504599(NKX2-1)

CUCA:

104061652(NKX2-1)

TEO:

104380497

BREG:

104639849(NKX2-1)

OHA:

104333880

ACAR:

104530501(NKX2-1)

CPEA:

104385415(NKX2-1)

CVF:	104288188(NKX2-1)

RTD:	128908819(NKX2-1)

CRID:

134514641(NKX2-1)

AAM:	106483143(NKX2-1)

AROW:

112977935(NKX2-1)

NPD:	112958025(NKX2-1)

TGT:	104574509(NKX2-1)

DNE:	112995424(NKX2-1)

SCAM:

104141561(NKX2-1)

ASN:	102368907(NKX2-1)

AMJ:	102569395(NKX2-1)

CPOO:

109320992(NKX2-1)

GGN:	109299462(NKX2-1)

PSS:	102444053 102460094(NKX2-1)

CMY:	102948066(NKX2-1)

CCAY:

125638897(NKX2-1)

DCC:	119846854 119856717(NKX2-1)

CPIC:

101945035(NKX2-1)

TST:	117876817(NKX2-1) 117888800

CABI:

116830471(NKX2-1) 116833894

MRV:	120388779 120404981(NKX2-1)

ACS:	100557406(nkx2-1) 103279322

ASAO:

132761825(NKX2-1)

PVT:	110083516(NKX2-1)

SUND:

121914447(NKX2-1)

PBI:	103052648(NKX2-1)

PMUR:

107284891(NKX2-1)

CTIG:

120311869(NKX2-1)

TSR:	106539475(NKX2-1) 106555202

PGUT:

117666118(NKX2-1)

APRI:

131190178(NKX2-1)

PTEX:

113439331(NKX2-1)

NSS:	113409943(NKX2-1)

VKO:	123026643(NKX2-1)

PMUA:

114592352(NKX2-1)

PRAF:

128409595(NKX2-1)

ZVI:	118082157(NKX2-1)

HCG:	128338284(NKX2-1)

GJA:	107112563(NKX2-1)

STOW:

125427515(NKX2-1)

EMC:	129324813(NKX2-1)

XLA:	108698633 373626(nkx2-1.L)

XTR:	100135015(nkx2-1) 100485697

NPR:	108797087(NKX2-1)

RTEM:

120914415 120920507(NKX2-1)

BBUF:

120977890 120981913(NKX2-1)

BGAR:

122919464 122922034(NKX2-1)

PWL:	138258802(NKX2-1) 138259624

MUO:	115477937(NKX2-1)

GSH:	117363938(NKX2-1)

DRE:	81883(nkx2.1)

SRX:	107730204 107741875(nkx2-1)

SANH:

107666245 107679765

SGH:	107578306 107582966

CCAR:

109107252 109108631

CAUA:

113060480 113117317

CGIB:

127933517 127976572

PTET:

122362056(nkx2.1)

LROH:

127180097(nkx2.1)

OMC:	131523377(nkx2.1)

PPRM:

120476322(nkx2.1)

RKG:	130080246(nkx2.1)

MAMB:

125269373(nkx2.1)

CIDE:

127499175

CERY:

137006937(nkx2.1)

MASI:

127411345 127454846

TROS:

130559964(nkx2.1)

TDW:	130437128(nkx2.1)

MANU:

129418362(nkx2.1)

PDAB:

135778356(nkx2.1)

IPU:	108269557(nkx2.1)

IFU:	128612668(nkx2.1)

PHYP:

113538887(nkx2-1)

SMEO:

124390270(nkx2.1)

TFD:	113659730(nkx2.1)

TVC:	132852064(nkx2.1)

CGAR:

128535976(nkx2.1)

NGRA:

132893885(nkx2.1)

TRN:	134325458(nkx2.1)

AMEX:

103043023(nkx2.1)

CMAO:

118823782(nkx2.1)

EEE:	113574141(nkx2-1)

CHAR:

105898011(nkx2.1)

SPIL:

134067827(nkx2.1)

TRU:	101073887(nkx2-1)

TFS:	130540317(nkx2.1)

LCO:	104929988(nkx2-1)

NCC:	104941582(nkx2-1)

TBEN:

117493902(nkx2.1)

CGOB:

115027430(nkx2-1)

PGEO:

117468067(nkx2.1)

GACU:

117558902(nkx2.1)

EMAC:

134881727(nkx2.1)

ELY:	117266823(nkx2.1)

EFO:	125901113(nkx2.1)

PLEP:

121954025(nkx2.1)

SLUC:

116057726(nkx2.1)

ECRA:

117936242(nkx2.1)

ESP:	116670372(nkx2-1)

PFLV:

114547261(nkx2-1)

GAT:	120833322(nkx2.1)

PPUG:

119228070(nkx2.1)

AFB:	129103879(nkx2.1)

CLUM:

117725204(nkx2.1)

PSWI:

130201547(nkx2.1)

CANA:

137787916(nkx2.1)

CVE:	137880383(nkx2.1)

MSAM:

119909859(nkx2.1)

SCHU:

122861570(nkx2.1)

CUD:	121526615(nkx2.1)

SPUL:

138591372(nkx2.1)

LMIX:

132993498(nkx2.1)

ALAT:

119034444(nkx2.1)

ASTR:

137611008(nkx2.1)

MZE:	101467819(nkx2-1)

ONL:	100702709(nkx2-1)

OAU:	116310328(nkx2.1)

OLA:	100049404(nkx2-1)

OML:	112143823(nkx2.1)

CSAI:

133462285(nkx2.1)

XMA:	102230451(nkx2-1)

XCO:	114133830(nkx2-1)

XHE:	116708551(nkx2-1)

PRET:

103458384(nkx2-1)

PFOR:

103148339(nkx2-1)

PLAI:

106952994(nkx2-1)

PMEI:

106920746(nkx2-1)

GAF:	122845933(nkx2.1)

PPRL:

129365428(nkx2.1)

CVG:	107095827(nkx2-1)

CTUL:

119788743(nkx2.1)

GMU:	124855704(nkx2.1)

NFU:	107392012(nkx2-1)

KMR:	108239045(nkx2.1)

ALIM:

106529798(nkx2-1)

NWH:	119427592(nkx2.1)

AOCE:

118470383(nkx2.1)

EJA:	138200206(nkx2.1)

BFRE:

138634304(nkx2.1)

MCEP:

125023774(nkx2.1)

CSEM:

103380542(nkx2-1)

POV:	109636330(nkx2-1)

SSEN:

122782486(nkx2.1)

SSOE:

131444825(nkx2.1)

HHIP:

117756468(nkx2.1)

HSP:	118116608(nkx2.1)

PPLT:

128451186(nkx2.1)

SMAU:

118286283(nkx2.1)

LCF:

108875097

SDU:	111225980(nkx2-1)

SLAL:

111673098(nkx2-1)

XGL:	120795629(nkx2.1)

HCQ:

109528123

SSCV:

125981270(nkx2.1)

SBIA:

133513038(nkx2.1)

PEE:	133412829(nkx2.1)

PTAO:

133488008(nkx2.1)

BPEC:

110156339(nkx2-1)

ENY:	140370896(nkx2.1)

MALB:

109964601(nkx2-1)

BSPL:

114848984(nkx2.1)

SJO:	128375408(nkx2.1)

SSCO:

134001038(nkx2.1)

GMH:	115543443(nkx2-1)

SASA:

106603787(nkx2-1) 106611304

STRU:

115162019 115172270(nkx2-1)

OTW:	112236002 112261540(nkx2.1)

OMY:	110497614(nkx2.1) 110505837

OGO:	124002014(nkx2.1) 124046684

ONE:	115139024 115146589(nkx2-1)

OKI:	109893874(nkx2-1) 109903231

OKE:	118362074(nkx2.1) 118375374

OMM:	135507918(nkx2.1) 135525594

OCLA:

139374191 139383847

SALP:

111963504 112068048(nkx2-1)

SNH:	120023809 120059943

CCLU:

121538873(nkx2.1) 121544298

ELS:	105026859(nkx2-1)

OEP:	134026706(nkx2.1)

SFM:	108921600(nkx2-1) 108924020

PKI:	111852002(nkx2-1) 111858982

AANG:

118224093(nkx2.1)

AROT:

135239855(nkx2.1)

CCOG:

133141560(nkx2.1)

LOC:	102685808(nkx2-1)

PSPA:

121324989(nkx2.1) 121330322

ARUT:

117424843 117973915

PSEX:

120518985(nkx2.1)

LCM:	102346775(NKX2-1)

CMK:	103178539(nkx2.1)

RTP:	109911367(nkx2.1)

CPLA:

122553678(nkx2.1)

HOC:	132818261(nkx2.1)

LERI:

129700237(nkx2.1)

PMRN:

116943240 116947098

LRJ:

133342355

BFO:

118423635

CIN:	445676(titf1)

SCLV:

120326748

SPU:	373506(NK2.1)

LPIC:

APLC:

ARUN:

AAMU:

AFIL:

SKO:	100303502(nkx2-1)

PFLL:

139149005

DME:	Dmel_CG17594(scro)

DER:

6544440

DSE:

6620502

DYA:	Dyak_GE11056

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23787

DAZ:

108620437

DNV:

115565479

DHE:

111600815

DVI:	6629705(scro)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

109429947 109430735 115253994 115257422 115257901

ASUA:

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	662616(nkx2.1)

TMOL:

138123606(scro)

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212817

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113504807 113504860

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM235910

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

HAMR:

FCD:

DMK:

DPZ:

AFRA:

PJA:	122256553 122263400

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128693876 128694023

PTRU:

123507139

ESN:

126983091

MNZ:	135197304 135197305

MRJ:	136841383 136841384

PORN:

HAZT:

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111244563 111244929

VJA:	111267414 111273125

TUT:	107369399 107369411

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106460005 106461316 106473638

PMEO:

129587127

NAI:	NECAME_02262

TSP:

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111131588 111131770

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

OBI:	106876811 106881899

OSN:

LJP:

LAK:

EGL:

LLON:

ATEN:

HMG:

Reference

PMID:23763999

Authors

Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T

Title

NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.

Journal

Cancer Cell 23:718-23 (2013)
DOI:10.1016/j.ccr.2013.04.002

Sequence

[hsa:7080]

LinkDB

DBGET integrated database retrieval system