KEGG   PATHWAY: ngi03320
Entry
ngi03320                    Pathway                                
Name
PPAR signaling pathway - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
ngi03320  PPAR signaling pathway
ngi03320

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103730720  Cd36; CD36 molecule [KO:K06259]
103742851  Slc27a4; solute carrier family 27 member 4 [KO:K08745] [EC:6.2.1.-]
103726896  Slc27a1; solute carrier family 27 member 1 [KO:K08745] [EC:6.2.1.-]
103733043  Slc27a2; solute carrier family 27 member 2 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103725476  Slc27a5; solute carrier family 27 member 5 [KO:K08748] [EC:6.2.1.7]
103740289  Slc27a6; solute carrier family 27 member 6 [KO:K08749]
103737042  Fabp1; fatty acid binding protein 1 [KO:K08750]
103744309  Fabp2; fatty acid binding protein 2 [KO:K08751]
103746125  Fabp3; fatty acid binding protein 3 [KO:K08752]
103727958  Fabp4; fatty acid binding protein 4 [KO:K08753]
103728084  fatty acid-binding protein, epidermal-like [KO:K08754]
103727955  Fabp5; fatty acid binding protein 5 [KO:K08754]
103724549  Fabp6; fatty acid binding protein 6 [KO:K08755]
103741816  Fabp7; fatty acid binding protein 7 [KO:K08756]
103743416  Ppara; peroxisome proliferator activated receptor alpha [KO:K07294]
103742823  Rxra; retinoid X receptor alpha [KO:K08524]
103739713  Rxrb; retinoid X receptor beta [KO:K08525]
103746119  Rxrg; retinoid X receptor gamma [KO:K08526]
103739671  Ppard; peroxisome proliferator activated receptor delta [KO:K04504]
103751484  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
103741353  Hmgcs1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 [KO:K01641] [EC:2.3.3.10]
103732003  Hmgcs2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 [KO:K01641] [EC:2.3.3.10]
103748325  Apoa1; apolipoprotein A1 [KO:K08757]
103745949  Apoa2; apolipoprotein A2 [KO:K08758]
103748337  Apoc3; apolipoprotein C3 [KO:K08759]
103748327  Apoa5; apolipoprotein A5 [KO:K09025]
103737948  Pltp; phospholipid transfer protein [KO:K08761]
103742967  Me3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
103729751  Me1; malic enzyme 1 [KO:K00029] [EC:1.1.1.40]
103729125  Fads2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
103744064  acyl-CoA desaturase 3-like [KO:K00507] [EC:1.14.19.1]
103744066  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
103744992  Scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103743979  acyl-CoA desaturase 2 [KO:K00507] [EC:1.14.19.1]
103743980  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
103732272  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
103747146  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
103742506  Nr1h3; nuclear receptor subfamily 1 group H member 3 [KO:K08536]
103727727  sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
103740711  Dbi; diazepam binding inhibitor, acyl-CoA binding protein [KO:K08762]
103730552  diazepam-binding inhibitor-like 5 [KO:K08762]
103747648  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103747021  Acsl6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
103750023  Acsl4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
103750478  Acsl1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
103727775  Acsl3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
103731745  Acsl5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
103737385  Acsbg2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
103726022  Acsbg1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
103745490  Olr1; oxidized low density lipoprotein receptor 1 [KO:K08763]
103732668  Ehhadh; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
103740657  cytochrome P450 4A14-like [KO:K07425] [EC:1.14.14.80]
103744661  3-ketoacyl-CoA thiolase B, peroxisomal [KO:K07513] [EC:2.3.1.16]
103751604  3-ketoacyl-CoA thiolase A, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
103730241  Scp2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
103732704  Acox1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]
103733928  Acox3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
103740540  Acox2; acyl-CoA oxidase 2 [KO:K10214] [EC:1.17.99.3]
103744525  Cpt1a; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
103735491  Cpt1b; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
103743677  Cpt1c; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
103730274  Cpt2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
103744464  Acadl; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
103746470  Acadm; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
103743316  Angptl4; angiopoietin like 4 [KO:K08767]
103733221  Sorbs1; sorbin and SH3 domain containing 1 [KO:K06086]
103749907  Plin1; perilipin 1 [KO:K08768]
103743965  Plin2; perilipin 2 [KO:K17284]
103737392  Plin4; perilipin 4 [KO:K20254]
103737225  Plin5; perilipin 5 [KO:K20255]
103750096  Adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296]
103731579  interstitial collagenase A-like [KO:K01388] [EC:3.4.24.7]
103731678  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
103742377  Ucp1; uncoupling protein 1 [KO:K08769]
103737567  Ilk; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
103743959  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103739439  Pck2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
103741614  Pck1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
103739767  glycerol kinase-like [KO:K00864] [EC:2.7.1.30]
103742620  Gk2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
103725387  Gk; glycerol kinase [KO:K00864] [EC:2.7.1.30]
103741588  Aqp7; aquaporin 7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
ngi00071  Fatty acid degradation
ngi00120  Primary bile acid biosynthesis
ngi00564  Glycerophospholipid metabolism
ngi04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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